SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xnu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 11 SER A 349
LEU A  73
ILE A 351
ALA A 354
SER A 356
None
None
CLR  A 604 (-4.3A)
None
CL  A 603 (-2.9A)
1.15A 1eqgB-4xnuA:
undetectable
1eqgB-4xnuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 VAL A 487
LEU A 531
GLY A 324
PRO A 323
PHE A 319
None
1.14A 1fduA-4xnuA:
undetectable
1fduA-4xnuA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 10 PHE A 452
TYR A 247
VAL A 246
ILE A 127
LEU A 419
None
1.26A 1fe2A-4xnuA:
undetectable
1fe2A-4xnuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 ILE A 429
GLY A  94
ALA A 428
ARG A 101
VAL A 574
None
1.26A 1i9gA-4xnuA:
undetectable
1i9gA-4xnuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 PHE A  53
ALA A 359
LEU A 279
LEU A 414
LEU A 276
CL  A 603 ( 4.8A)
None
None
None
CLR  A 604 ( 4.7A)
1.44A 1jipA-4xnuA:
0.3
1jipA-4xnuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 11 LEU A 367
TYR A  58
TYR A  55
PRO A 386
LEU A 388
None
1.36A 1klmA-4xnuA:
undetectable
1klmA-4xnuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 11 GLU A 161
VAL A 381
ILE A 378
LEU A 367
PHE A 364
None
1.16A 2dg9A-4xnuA:
undetectable
2dg9A-4xnuA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 SER A 131
LEU A 388
GLY A 387
PHE A 390
TYR A  55
None
1.19A 2kceB-4xnuA:
undetectable
2kceB-4xnuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
3 / 3 ASN A 224
ARG A 225
ASP A 238
None
0.93A 2qe6A-4xnuA:
undetectable
2qe6A-4xnuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
3 / 3 ASN A 224
ARG A 225
ASP A 238
None
0.95A 2qe6B-4xnuA:
undetectable
2qe6B-4xnuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 134
PHE A 411
TRP A 145
GLY A 387
None
1.42A 2qmzA-4xnuA:
undetectable
2qmzB-4xnuA:
undetectable
2qmzA-4xnuA:
18.75
2qmzB-4xnuA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 468
PHE A 471
TRP A 130
GLY A 385
None
1.36A 2qmzA-4xnuA:
undetectable
2qmzB-4xnuA:
undetectable
2qmzA-4xnuA:
18.75
2qmzB-4xnuA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 8 ILE A 304
PHE A  53
GLY A  62
GLY A  63
None
CL  A 603 ( 4.8A)
None
None
0.90A 2qx4A-4xnuA:
undetectable
2qx4B-4xnuA:
undetectable
2qx4A-4xnuA:
18.75
2qx4B-4xnuA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 7 PHE A 470
PHE A 118
SER A 426
GLY A 459
None
0.99A 2v0mC-4xnuA:
undetectable
2v0mC-4xnuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 7 TYR A 124
ILE A 128
GLY A 418
PHE A 390
41U  A 605 ( 3.8A)
None
NA  A 602 ( 4.2A)
None
1.02A 2vctD-4xnuA:
undetectable
2vctD-4xnuA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 SER A 462
LEU A 474
ILE A 229
LEU A 243
TYR A 247
None
1.36A 2xkwA-4xnuA:
undetectable
2xkwA-4xnuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.02A 2y69C-4xnuA:
1.6
2y69J-4xnuA:
undetectable
2y69C-4xnuA:
20.59
2y69J-4xnuA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.00A 2y69P-4xnuA:
1.6
2y69W-4xnuA:
undetectable
2y69P-4xnuA:
20.59
2y69W-4xnuA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.00A 3abmC-4xnuA:
1.6
3abmJ-4xnuA:
undetectable
3abmC-4xnuA:
20.59
3abmJ-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.04A 3abmP-4xnuA:
1.6
3abmW-4xnuA:
undetectable
3abmP-4xnuA:
20.59
3abmW-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.08A 3ag3C-4xnuA:
1.6
3ag3J-4xnuA:
undetectable
3ag3C-4xnuA:
20.59
3ag3J-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
3 / 3 THR A  29
SER A 259
LYS A 263
None
1.20A 3aocC-4xnuA:
undetectable
3aocC-4xnuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A  43
GLY A 425
ALA A 428
LEU A 254
41U  A 605 (-4.2A)
41U  A 605 ( 3.7A)
None
None
0.88A 3bgdA-4xnuA:
undetectable
3bgdA-4xnuA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 8 MET A 239
ALA A 240
LEU A 243
ILE A 229
None
0.64A 3cldB-4xnuA:
0.7
3cldB-4xnuA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 GLY A  42
SER A 421
GLY A 424
LEU A 417
ALA A 269
NA  A 602 (-4.4A)
NA  A 602 ( 2.4A)
None
None
None
0.92A 3douA-4xnuA:
undetectable
3douA-4xnuA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 8 SER A 353
TYR A  69
LEU A  80
PRO A  79
None
1.12A 3jq7B-4xnuA:
undetectable
3jq7B-4xnuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 7 TYR A  55
GLU A 379
LEU A  56
ASN A  60
None
1.03A 3k8mA-4xnuA:
undetectable
3k8mA-4xnuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 TYR A  58
THR A 383
ARG A  52
LEU A  56
None
1.37A 3qelC-4xnuA:
undetectable
3qelC-4xnuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 GLY A  77
LEU A  73
PHE A  81
ALA A 345
SER A 349
None
1.12A 3tbgB-4xnuA:
undetectable
3tbgB-4xnuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 361
LEU A  66
GLY A  63
ILE A 293
None
0.86A 3wrkA-4xnuA:
0.6
3wrkA-4xnuA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM4_A_8PRA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.73A 4mm4A-4xnuA:
40.2
4mm4A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM4_B_8PRB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.32A 4mm4B-4xnuA:
40.3
4mm4B-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM5_A_SREA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 9 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.85A 4mm5A-4xnuA:
40.4
4mm5A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM5_A_SREA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.63A 4mm5A-4xnuA:
40.4
4mm5A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM6_A_29EA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
TYR A 124
PHE A 325
VAL A 327
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.77A 4mm6A-4xnuA:
40.4
4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM6_A_29EA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 ASP A  46
TYR A 124
VAL A 327
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
None
NA  A 602 ( 2.4A)
None
0.94A 4mm6A-4xnuA:
40.4
4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM6_A_29EA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
VAL A 327
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.69A 4mm6A-4xnuA:
40.4
4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM7_A_29JA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 10 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.71A 4mm7A-4xnuA:
42.0
4mm7A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM8_A_RFXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 ASP A  46
GLY A 322
PHE A 325
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
None
41U  A 605 ( 3.7A)
0.99A 4mm8A-4xnuA:
42.2
4mm8A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM8_A_RFXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
41U  A 605 ( 3.7A)
0.80A 4mm8A-4xnuA:
42.2
4mm8A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM8_A_RFXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 422
GLY A 425
ASP A 475
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
None
41U  A 605 ( 3.7A)
None
0.94A 4mm8A-4xnuA:
42.2
4mm8A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 11 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
0.92A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 11 ASP A  46
TYR A 124
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.72A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 11 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.50A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 11 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.69A 4mm9A-4xnuA:
41.6
4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 11 TYR A 124
PHE A 325
SER A 421
SER A 422
GLY A 424
41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
None
1.25A 4mmaA-4xnuA:
40.1
4mmaA-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 11 TYR A 124
PHE A 325
SER A 421
SER A 422
GLY A 425
41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
0.88A 4mmaA-4xnuA:
40.1
4mmaA-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 9 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.79A 4mmbA-4xnuA:
40.9
4mmbA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.58A 4mmbA-4xnuA:
40.9
4mmbA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 10 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.64A 4mmcA-4xnuA:
40.8
4mmcA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 10 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.55A 4mmcA-4xnuA:
40.8
4mmcA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 10 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.70A 4mmcA-4xnuA:
40.8
4mmcA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 10 ASP A  46
GLY A 322
PHE A 325
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
None
41U  A 605 ( 3.7A)
0.94A 4mmdA-4xnuA:
41.0
4mmdA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 10 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
41U  A 605 ( 3.7A)
0.82A 4mmdA-4xnuA:
41.0
4mmdA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
GLY A 322
PHE A 325
SER A 421
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
0.82A 4mmdB-4xnuA:
41.0
4mmdB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
TYR A 124
GLY A 322
SER A 421
SER A 422
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
None
1.23A 4mmdB-4xnuA:
41.0
4mmdB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
8 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
0.72A 4mmdB-4xnuA:
41.0
4mmdB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.54A 4mmeA-4xnuA:
40.9
4mmeA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.56A 4mmeB-4xnuA:
40.8
4mmeB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 9 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
1.00A 4mmfA-4xnuA:
40.9
4mmfA-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.68A 4mmfA-4xnuA:
40.9
4mmfA-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 9 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
1.03A 4mmfB-4xnuA:
40.7
4mmfB-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.66A 4mmfB-4xnuA:
40.7
4mmfB-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 12 GLY A  88
HIS A  90
SER A  39
LEU A 329
SER A 261
None
1.32A 4pooA-4xnuA:
undetectable
4pooA-4xnuA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 8 PHE A 468
TYR A 123
PHE A 471
TRP A 130
GLY A 385
None
1.43A 4qoiA-4xnuA:
undetectable
4qoiB-4xnuA:
undetectable
4qoiA-4xnuA:
18.75
4qoiB-4xnuA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XNX_A_41XA707_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
11 / 11 PHE A  43
ASP A  46
ALA A 117
VAL A 120
ASP A 121
TYR A 123
TYR A 124
GLY A 322
VAL A 327
SER A 421
GLY A 425
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.31A 4xnxA-4xnuA:
63.2
4xnxA-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XNX_A_41XA707_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 11 PHE A  43
ASP A  46
ALA A 428
GLY A 322
SER A 421
GLY A 424
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
None
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
1.28A 4xnxA-4xnuA:
63.2
4xnxA-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XNX_A_41XA707_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 11 PHE A  43
ASP A  46
TYR A 124
GLY A 322
VAL A 327
SER A 421
GLY A 424
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
NA  A 602 ( 2.4A)
None
0.92A 4xnxA-4xnuA:
63.2
4xnxA-4xnuA:
98.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 7 TYR A 393
VAL A 362
ILE A 278
LEU A 414
None
1.18A 4xo7B-4xnuA:
undetectable
4xo7B-4xnuA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 10 ASP A 121
ASP A  46
SER A 422
SER A 421
GLY A 418
41U  A 605 ( 4.2A)
41U  A 605 ( 3.3A)
None
NA  A 602 ( 2.4A)
NA  A 602 ( 4.2A)
1.38A 4xp1A-4xnuA:
63.0
4xp1A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
9 / 10 PHE A  43
ASP A  46
ALA A 117
VAL A 120
ASP A 121
TYR A 124
SER A 421
SER A 422
GLY A 425
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
0.58A 4xp1A-4xnuA:
63.0
4xp1A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 10 PHE A  43
ASP A  46
TYR A 124
SER A 421
SER A 422
GLY A 424
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
None
None
1.11A 4xp1A-4xnuA:
63.0
4xp1A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 11 PHE A  43
ASP A  46
ALA A  48
GLY A 322
PHE A 325
SER A 421
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
NA  A 601 ( 4.6A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
0.82A 4xp4A-4xnuA:
62.8
4xp4A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 11 PHE A  43
ASP A  46
ALA A  48
TYR A 124
GLY A 322
SER A 421
GLY A 424
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
NA  A 601 ( 4.6A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
0.88A 4xp4A-4xnuA:
62.8
4xp4A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
10 / 11 PHE A  43
ASP A  46
ALA A  48
VAL A 120
ASP A 121
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
NA  A 601 ( 4.6A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.61A 4xp4A-4xnuA:
62.8
4xp4A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP6_A_B40A601_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 ASP A  46
VAL A 120
ASP A 121
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
41U  A 605 ( 3.7A)
0.23A 4xp6A-4xnuA:
62.3
4xp6A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP6_A_B40A601_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 ASP A  46
VAL A 120
PHE A 325
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.7A)
41U  A 605 ( 3.7A)
0.80A 4xp6A-4xnuA:
62.3
4xp6A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP9_C_1WEC706_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 4 PHE A  43
ASP A  46
GLY A 322
SER A 421
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
0.38A 4xp9C-4xnuA:
62.6
4xp9C-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 10 PHE A  43
ASP A  46
GLY A 322
PHE A 325
SER A 421
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
0.85A 4xpbA-4xnuA:
61.8
4xpbA-4xnuA:
99.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 10 PHE A  43
ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
0.93A 4xpbA-4xnuA:
61.8
4xpbA-4xnuA:
99.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
8 / 10 PHE A  43
ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.36A 4xpbA-4xnuA:
61.8
4xpbA-4xnuA:
99.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 7 PHE A 325
ILE A 116
PHE A 319
THR A 535
41U  A 605 ( 4.7A)
None
None
None
0.89A 4zdzA-4xnuA:
undetectable
4zdzA-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 VAL A  45
ILE A 571
PRO A 323
THR A 535
NA  A 601 (-4.8A)
None
None
None
1.09A 4ze1A-4xnuA:
undetectable
4ze1A-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 7 PHE A 325
ILE A 116
PHE A 319
THR A 535
41U  A 605 ( 4.7A)
None
None
None
0.92A 4ze3A-4xnuA:
undetectable
4ze3A-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 8 ILE A  41
LEU A  37
ILE A 351
LEU A 347
None
CLR  A 604 (-4.4A)
CLR  A 604 (-4.3A)
None
0.81A 4zvcA-4xnuA:
2.1
4zvcB-4xnuA:
2.1
4zvcA-4xnuA:
12.17
4zvcB-4xnuA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 8 ILE A 351
LEU A 347
ILE A  41
LEU A  37
CLR  A 604 (-4.3A)
None
None
CLR  A 604 (-4.4A)
0.80A 4zvcA-4xnuA:
2.1
4zvcB-4xnuA:
2.1
4zvcA-4xnuA:
12.17
4zvcB-4xnuA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 8 PHE A 325
ILE A 116
PHE A 319
THR A 535
41U  A 605 ( 4.7A)
None
None
None
0.92A 5esjA-4xnuA:
undetectable
5esjA-4xnuA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 10 ASP A  46
ALA A 117
TYR A 124
GLY A 322
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.57A 5i6xA-4xnuA:
55.0
5i6xA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 10 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
0.77A 5i6xA-4xnuA:
55.0
5i6xA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
TYR A 123
PHE A 319
GLY A 322
GLY A 425
GLY A 480
41U  A 605 ( 3.3A)
None
None
41U  A 605 ( 4.1A)
41U  A 605 ( 3.7A)
None
0.36A 5i71A-4xnuA:
53.8
5i71A-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
TYR A 123
PHE A 319
GLY A 322
GLY A 425
GLY A 480
41U  A 605 ( 3.3A)
None
None
41U  A 605 ( 4.1A)
41U  A 605 ( 3.7A)
None
0.42A 5i73A-4xnuA:
54.4
5i73A-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 12 ASP A  46
TYR A 123
GLY A 322
SER A 421
GLY A 425
GLY A 480
41U  A 605 ( 3.3A)
None
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
0.31A 5i75A-4xnuA:
54.5
5i75A-4xnuA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 4 LEU A 433
ARG A 444
ILE A 440
PHE A 447
None
0.88A 5kirB-4xnuA:
0.0
5kirB-4xnuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
3 / 3 TYR A 469
ALA A 548
TYR A 547
None
0.73A 5uunB-4xnuA:
undetectable
5uunB-4xnuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 LEU A 321
LEU A  87
ILE A  78
LEU A 346
PHE A 503
ILE A 507
None
1.36A 5vkqC-4xnuA:
1.0
5vkqD-4xnuA:
undetectable
5vkqC-4xnuA:
16.03
5vkqD-4xnuA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.10A 5wauC-4xnuA:
1.5
5wauJ-4xnuA:
undetectable
5wauC-4xnuA:
20.59
5wauJ-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.07A 5wauc-4xnuA:
1.6
5wauj-4xnuA:
undetectable
5wauc-4xnuA:
20.59
5wauj-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.03A 5xdqC-4xnuA:
1.6
5xdqJ-4xnuA:
undetectable
5xdqC-4xnuA:
20.59
5xdqJ-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 5 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.03A 5xdqP-4xnuA:
1.6
5xdqW-4xnuA:
undetectable
5xdqP-4xnuA:
20.59
5xdqW-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.02A 5z84P-4xnuA:
undetectable
5z84W-4xnuA:
undetectable
5z84P-4xnuA:
20.59
5z84W-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.06A 5z85P-4xnuA:
1.6
5z85W-4xnuA:
undetectable
5z85P-4xnuA:
20.59
5z85W-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.01A 5z86C-4xnuA:
undetectable
5z86J-4xnuA:
undetectable
5z86C-4xnuA:
20.59
5z86J-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
0.98A 5z86P-4xnuA:
undetectable
5z86W-4xnuA:
undetectable
5z86P-4xnuA:
20.59
5z86W-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.00A 5zcoP-4xnuA:
1.8
5zcoW-4xnuA:
undetectable
5zcoP-4xnuA:
20.59
5zcoW-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.03A 5zcpC-4xnuA:
undetectable
5zcpJ-4xnuA:
undetectable
5zcpC-4xnuA:
20.59
5zcpJ-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
4 / 6 PHE A 489
PHE A 106
LEU A 105
PHE A 590
None
1.02A 5zcpP-4xnuA:
undetectable
5zcpW-4xnuA:
undetectable
5zcpP-4xnuA:
20.59
5zcpW-4xnuA:
7.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 9 ASP A  46
ALA A 117
PHE A 319
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
None
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.70A 6awoA-4xnuA:
54.2
6awoA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
5 / 9 ASN A 352
ILE A 127
SER A 320
SER A 421
SER A 422
NA  A 601 (-3.6A)
None
NA  A 601 (-2.4A)
NA  A 602 ( 2.4A)
None
1.31A 6awpA-4xnuA:
54.2
6awpA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 9 ASP A  46
ASN A  49
SER A 320
PHE A 325
SER A 421
SER A 422
GLY A 425
41U  A 605 ( 3.3A)
NA  A 601 (-2.9A)
NA  A 601 (-2.4A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
0.48A 6awpA-4xnuA:
54.2
6awpA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
6 / 9 ASP A  46
ASN A  49
SER A 320
SER A 421
SER A 422
GLY A 424
41U  A 605 ( 3.3A)
NA  A 601 (-2.9A)
NA  A 601 (-2.4A)
NA  A 602 ( 2.4A)
None
None
0.86A 6awpA-4xnuA:
54.2
6awpA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster)
7 / 9 ASP A  46
ALA A 117
PHE A 319
GLY A 322
PHE A 325
SER A 421
GLY A 425
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
None
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
0.69A 6awqA-4xnuA:
54.2
6awqA-4xnuA:
53.25