SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		6 / 12 TYR L  36
GLN L  89
PHE L  98
ASN H  35
VAL H  37
TRP H 103
 None
 0.82A 1h8sA-4xnyL:
20.0		 1h8sA-4xnyL:
36.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.68A 1ictD-4xnyL:
undetectable		 1ictD-4xnyL:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		5 / 11 LEU L 104
GLU L  17
VAL L  13
LEU L  47
LEU L  73
 None
 1.33A 1mrqA-4xnyL:
undetectable		 1mrqA-4xnyL:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		4 / 8 PRO H 126
LEU H 189
GLY H 190
LEU H 138
 None
 0.96A 1ya4A-4xnyH:
undetectable		 1ya4A-4xnyH:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.92A 2aojA-4xnyL:
undetectable		 2aojA-4xnyL:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		3 / 3 PHE L  91
CYH L  90
HIS L  32
 None
 1.09A 3u9fF-4xnyL:
undetectable		 3u9fF-4xnyL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		3 / 3 PHE L  91
CYH L  90
HIS L  32
 None
 1.06A 3u9fG-4xnyL:
undetectable		 3u9fG-4xnyL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		3 / 3 PHE L  91
CYH L  90
HIS L  32
 None
 1.05A 3u9fL-4xnyL:
undetectable		 3u9fL-4xnyL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		3 / 3 PHE L  91
CYH L  90
HIS L  32
 None
 1.14A 3u9fS-4xnyL:
undetectable		 3u9fS-4xnyL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		5 / 12 ASN H  35
GLN L  89
LEU L  46
GLN H   4
ILE H  34
 None
 1.40A 4p6xE-4xnyH:
undetectable		 4p6xE-4xnyH:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		5 / 12 TYR L  36
GLY L  97
GLN L   6
ILE L   2
ILE L  28
 None
 1.00A 4uw0A-4xnyL:
undetectable		 4uw0A-4xnyL:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		3 / 3 TYR H  79
THR H  81
THR H  70
 None
 0.76A 5aoxB-4xnyH:
undetectable		 5aoxB-4xnyH:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		3 / 3 TYR H  79
THR H  81
THR H  70
 None
 0.77A 5aoxE-4xnyH:
undetectable		 5aoxE-4xnyH:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		4 / 6 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.37A 5b6iB-4xnyL:
undetectable		 5b6iB-4xnyL:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		5 / 9 LEU L 104
ALA L  84
PHE L  83
VAL L  78
ILE L  75
 None
 1.21A 5om2A-4xnyL:
undetectable
5om2B-4xnyL:
undetectable		 5om2A-4xnyL:
15.76
5om2B-4xnyL:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		6 / 12 GLU H  46
LEU H  82
LEU H  82
LEU H  20
ALA H  88
GLU H  40
 None
 1.31A 5v0vA-4xnyH:
undetectable		 5v0vA-4xnyH:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4xny HEAVY CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens) 		5 / 12 THR H  83
VAL H 111
VAL H 109
VAL H  67
TYR H  90
 None
 1.32A 6iblB-4xnyH:
undetectable		 6iblB-4xnyH:
19.05