SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  10
THR L  97
PRO L   8
 None
 0.87A 1a7yB-4xnzL:
undetectable		 1a7yB-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		4 / 7 ALA L  98
SER L  14
SER L  12
THR L  10
 None
NAG  L 301 ( 4.2A)
None
None
 0.85A 1dvxA-4xnzL:
3.7		 1dvxA-4xnzL:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  10
THR L  97
PRO L   8
 None
 0.85A 1i3wE-4xnzL:
undetectable		 1i3wE-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.87A 1i3wG-4xnzL:
undetectable		 1i3wG-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.74A 1unjF-4xnzL:
undetectable		 1unjF-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.84A 1unjL-4xnzL:
undetectable		 1unjL-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.84A 1unjR-4xnzL:
undetectable		 1unjR-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.85A 1unjX-4xnzL:
undetectable		 1unjX-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.84A 1unmE-4xnzL:
undetectable		 1unmE-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 THR L  97
PRO L   8
THR L  10
 None
 0.78A 4hivD-4xnzL:
undetectable		 4hivD-4xnzL:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.90A 4pwjB-4xnzL:
undetectable		 4pwjB-4xnzL:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4xnz LIGHT CHAIN OF
ANTIBODY VRC06B
(Homo
sapiens) 		3 / 3 ARG L  44
PRO L  58
TYR L  85
 None
 0.99A 5tzoB-4xnzL:
undetectable		 5tzoB-4xnzL:
20.17