SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xoq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 299
ALA A 425
VAL A 348
 None
 0.92A 1c4dA-4xoqA:
undetectable
1c4dB-4xoqA:
undetectable		 1c4dA-4xoqA:
13.89
1c4dB-4xoqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 425
VAL A 348
TRP A 299
 None
 0.85A 1c4dC-4xoqA:
undetectable
1c4dD-4xoqA:
undetectable		 1c4dC-4xoqA:
13.89
1c4dD-4xoqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 299
ALA A 425
VAL A 348
 None
 0.72A 1c4dC-4xoqA:
undetectable
1c4dD-4xoqA:
undetectable		 1c4dC-4xoqA:
13.89
1c4dD-4xoqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 426
ALA A 344
LEU A 300
SER A 400
ILE A 424
 None
None
None
F42  A 501 (-4.9A)
None
 0.98A 1rb3B-4xoqA:
undetectable		 1rb3B-4xoqA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 394
SER A 395
ALA A 389
ALA A 387
LEU A 384
 None
 1.03A 1ukbA-4xoqA:
undetectable		 1ukbA-4xoqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 422
ILE A 398
GLY A 378
PHE A 297
ILE A 424
 None
F42  A 501 (-4.5A)
None
None
None
 1.11A 4qoiA-4xoqA:
undetectable
4qoiB-4xoqA:
undetectable		 4qoiA-4xoqA:
22.55
4qoiB-4xoqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 388
GLY A 394
SER A 400
LEU A 310
ILE A 340
 None
None
F42  A 501 (-4.9A)
None
None
 1.15A 6bxmA-4xoqA:
undetectable		 6bxmA-4xoqA:
20.30