SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 SER A 164
VAL A 337
GLY A 336
GLY A 234
SER A  14
None
1.03A 1fduC-4xoxA:
undetectable
1fduC-4xoxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 THR A 328
SER A 230
ALA A 331
GLY A  16
ILE A  12
None
1.19A 1gtnH-4xoxA:
undetectable
1gtnI-4xoxA:
undetectable
1gtnH-4xoxA:
11.39
1gtnI-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 11 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.17A 1gtnM-4xoxA:
undetectable
1gtnN-4xoxA:
undetectable
1gtnM-4xoxA:
11.39
1gtnN-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 8 SER A 104
VAL A 140
SER A 141
ASN A 154
None
1.25A 1hwiB-4xoxA:
undetectable
1hwiB-4xoxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 8 SER A 104
VAL A 140
SER A 141
ASN A 154
None
1.21A 1hwkA-4xoxA:
undetectable
1hwkA-4xoxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 8 SER A 104
VAL A 140
SER A 141
ASN A 154
None
1.19A 1hwkC-4xoxA:
undetectable
1hwkC-4xoxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 8 SER A 104
VAL A 140
SER A 141
ASN A 154
None
1.19A 1hwkD-4xoxA:
undetectable
1hwkD-4xoxA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1502_0
(RAS-RELATED PROTEIN
RAB-9A)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 4 HIS A 330
ILE A 229
GLN A 195
PHE A 227
None
1.23A 1s8fA-4xoxA:
0.0
1s8fB-4xoxA:
0.0
1s8fA-4xoxA:
16.75
1s8fB-4xoxA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ILE A 182
GLY A   8
ILE A  83
VAL A   5
GLU A 240
None
1.08A 1sg9A-4xoxA:
undetectable
1sg9A-4xoxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 LEU A  52
SER A  14
THR A 328
ALA A 334
ALA A 335
None
1.35A 1wygA-4xoxA:
undetectable
1wygA-4xoxA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 11 ALA A 394
ALA A 165
LEU A 396
ALA A 340
GLU A 339
None
1.06A 2bxeB-4xoxA:
undetectable
2bxeB-4xoxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 8 GLY A 169
GLY A 259
THR A 395
ALA A 394
ALA A 260
None
0.96A 2ej3A-4xoxA:
undetectable
2ej3A-4xoxA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A 169
GLY A 259
THR A 395
ALA A 394
ALA A 260
None
0.95A 2ej3B-4xoxA:
undetectable
2ej3B-4xoxA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 6 ARG A 277
SER A 271
GLY A 391
THR A 392
None
1.13A 2f7fA-4xoxA:
undetectable
2f7fA-4xoxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
3 / 3 ASP A 225
ARG A 224
ARG A 218
None
0.89A 2j9dA-4xoxA:
undetectable
2j9dC-4xoxA:
undetectable
2j9dA-4xoxA:
17.19
2j9dC-4xoxA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 5 GLN A 195
PHE A 199
PHE A 227
GLY A 231
None
1.44A 2qmzA-4xoxA:
undetectable
2qmzB-4xoxA:
undetectable
2qmzA-4xoxA:
20.60
2qmzB-4xoxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 7 GLY A 329
GLY A 105
GLN A 195
PHE A 199
None
0.95A 2qwxA-4xoxA:
undetectable
2qwxB-4xoxA:
undetectable
2qwxA-4xoxA:
19.90
2qwxB-4xoxA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 7 GLY A 105
GLN A 195
PHE A 199
PHE A 227
None
1.18A 2qx4A-4xoxA:
undetectable
2qx4B-4xoxA:
undetectable
2qx4A-4xoxA:
20.60
2qx4B-4xoxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 6 GLY A 231
GLY A 105
GLN A 195
PHE A 199
PHE A 227
None
1.47A 2qx6A-4xoxA:
undetectable
2qx6B-4xoxA:
undetectable
2qx6A-4xoxA:
20.60
2qx6B-4xoxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 6 GLY A 231
GLY A 106
PHE A 199
PHE A 227
None
0.92A 2qx6A-4xoxA:
undetectable
2qx6B-4xoxA:
undetectable
2qx6A-4xoxA:
20.60
2qx6B-4xoxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 GLY A 187
GLY A 103
ALA A 107
ALA A 185
VAL A 101
None
0.99A 2yvlA-4xoxA:
undetectable
2yvlA-4xoxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 GLY A 187
GLY A 103
ALA A 107
ALA A 185
VAL A 101
None
0.99A 2yvlB-4xoxA:
undetectable
2yvlB-4xoxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 GLY A 187
GLY A 103
ALA A 107
ALA A 185
VAL A 101
None
1.00A 2yvlD-4xoxA:
undetectable
2yvlD-4xoxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 11 SER A 322
LEU A  26
MET A 327
ILE A  15
ALA A 334
None
1.09A 2zbzA-4xoxA:
undetectable
2zbzA-4xoxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 11 SER A 322
LEU A  26
VAL A  22
MET A 327
ILE A  15
None
1.21A 2zbzA-4xoxA:
undetectable
2zbzA-4xoxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLU A 189
GLY A 329
ALA A 216
PHE A  39
THR A  34
None
1.34A 3a3yA-4xoxA:
undetectable
3a3yA-4xoxA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 6 GLY A 232
GLY A 188
GLY A 187
GLY A 233
GLY A 186
None
1.37A 3bogA-4xoxA:
undetectable
3bogC-4xoxA:
undetectable
3bogA-4xoxA:
undetectable
3bogC-4xoxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
3 / 3 MET A 327
VAL A  22
GLU A 339
None
0.87A 3c6gA-4xoxA:
undetectable
3c6gA-4xoxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.94A 3fhjA-4xoxA:
undetectable
3fhjA-4xoxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.89A 3fhjB-4xoxA:
undetectable
3fhjB-4xoxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.88A 3fhjC-4xoxA:
undetectable
3fhjC-4xoxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.89A 3fhjE-4xoxA:
undetectable
3fhjE-4xoxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.94A 3fi0A-4xoxA:
undetectable
3fi0A-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.88A 3fi0C-4xoxA:
undetectable
3fi0C-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.97A 3fi0D-4xoxA:
undetectable
3fi0D-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.89A 3fi0F-4xoxA:
undetectable
3fi0F-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.88A 3fi0H-4xoxA:
undetectable
3fi0H-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.97A 3fi0J-4xoxA:
undetectable
3fi0J-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.91A 3fi0K-4xoxA:
undetectable
3fi0K-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.95A 3fi0M-4xoxA:
undetectable
3fi0M-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.87A 3fi0N-4xoxA:
undetectable
3fi0N-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
0.89A 3fi0O-4xoxA:
undetectable
3fi0O-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLN A 402
ASP A 290
ILE A 289
VAL A 397
VAL A 256
None
1.01A 3fi0R-4xoxA:
undetectable
3fi0R-4xoxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 SER A 164
THR A 163
GLY A 232
GLY A 188
GLN A  81
None
1.20A 3fzgA-4xoxA:
undetectable
3fzgA-4xoxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 SER A 164
THR A 163
GLY A 232
GLY A 188
LEU A 332
None
1.28A 3fzgA-4xoxA:
undetectable
3fzgA-4xoxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 GLY A 232
SER A  13
TYR A 342
LEU A 345
SER A  78
None
1.30A 3n2oA-4xoxA:
undetectable
3n2oB-4xoxA:
0.2
3n2oA-4xoxA:
20.60
3n2oB-4xoxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ALA A 102
ILE A 341
GLY A 233
ALA A  75
VAL A 236
None
0.94A 3rukB-4xoxA:
undetectable
3rukB-4xoxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 6 SER A 104
LEU A 332
HIS A 330
THR A 163
None
1.27A 3thrB-4xoxA:
undetectable
3thrB-4xoxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 5 PRO A 354
SER A  31
LYS A  30
GLY A  29
None
1.17A 3tkdB-4xoxA:
undetectable
3tkdB-4xoxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 5 PRO A 354
SER A  31
LYS A  30
GLY A  29
None
1.14A 3tkdA-4xoxA:
undetectable
3tkdA-4xoxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 6 MET A 235
LEU A  79
PRO A 147
GLN A  64
None
1.14A 3vkxA-4xoxA:
undetectable
3vkxA-4xoxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 5 ASP A 263
GLU A 273
GLY A 272
TYR A 265
None
1.22A 3w9tB-4xoxA:
undetectable
3w9tB-4xoxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 5 ASP A 263
GLU A 273
GLY A 272
TYR A 265
None
1.23A 3w9tD-4xoxA:
undetectable
3w9tD-4xoxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 SER A 164
GLY A 336
GLY A 232
GLY A 188
ILE A  12
None
0.89A 4ctkC-4xoxA:
undetectable
4ctkC-4xoxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 6 ALA A 340
LEU A 396
VAL A 397
GLU A 254
None
1.00A 4g24A-4xoxA:
undetectable
4g24A-4xoxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ILE A  15
GLY A  50
GLY A  32
ILE A 229
LEU A 332
None
0.96A 4iv0A-4xoxA:
undetectable
4iv0A-4xoxA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
11 / 12 GLY A 105
ALA A 160
CYH A 161
GLU A 189
PHE A 199
HIS A 295
THR A 297
HIS A 330
LEU A 332
GLY A 388
PHE A 389
None
0.63A 4ls7A-4xoxA:
62.9
4ls7A-4xoxA:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
6 / 12 GLY A 106
GLU A 189
PHE A 199
HIS A 330
LEU A 332
PHE A 389
None
1.00A 4ls7A-4xoxA:
62.9
4ls7A-4xoxA:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
8 / 12 GLY A 333
ALA A 160
CYH A 161
GLU A 189
PHE A 199
LEU A 332
GLY A 388
PHE A 389
None
1.48A 4ls7A-4xoxA:
62.9
4ls7A-4xoxA:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
6 / 12 GLY A 333
ALA A 160
CYH A 161
PHE A 227
HIS A 295
PHE A 389
None
1.23A 4ls7A-4xoxA:
62.9
4ls7A-4xoxA:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
9 / 12 ALA A 160
CYH A 161
PHE A 199
HIS A 295
THR A 297
HIS A 330
LEU A 332
GLY A 388
PHE A 389
None
0.61A 4ls7A-4xoxA:
62.9
4ls7B-4xoxA:
62.5
4ls7A-4xoxA:
43.16
4ls7B-4xoxA:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 7 ILE A 370
LEU A 307
ASP A 303
THR A 299
None
0.79A 4mmcA-4xoxA:
undetectable
4mmcA-4xoxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ILE A  15
GLY A  50
GLY A  32
ILE A 229
LEU A 332
None
1.01A 4mwzA-4xoxA:
undetectable
4mwzA-4xoxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ILE A  15
GLY A  50
GLY A  32
ILE A 229
LEU A 332
None
0.95A 4mwzB-4xoxA:
undetectable
4mwzB-4xoxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ALA A 334
SER A 164
GLY A 186
MET A   9
GLY A  10
None
1.29A 4r29A-4xoxA:
undetectable
4r29A-4xoxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 7 GLY A 233
GLY A 234
ALA A 334
ILE A 341
None
0.70A 4yjiA-4xoxA:
undetectable
4yjiA-4xoxA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 SER A 156
SER A 109
GLU A 190
THR A 163
GLY A 333
None
1.40A 4zjlA-4xoxA:
undetectable
4zjlA-4xoxA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 5 THR A 261
GLY A 274
GLU A 306
HIS A 295
None
1.06A 5c0oH-4xoxA:
undetectable
5c0oH-4xoxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 4 VAL A   4
ALA A 244
ILE A   6
THR A   7
None
1.08A 5e4dB-4xoxA:
undetectable
5e4dB-4xoxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5eevO-4xoxA:
undetectable
5eevP-4xoxA:
undetectable
5eevO-4xoxA:
11.39
5eevP-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5eewO-4xoxA:
undetectable
5eewP-4xoxA:
undetectable
5eewO-4xoxA:
11.39
5eewP-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5eexO-4xoxA:
undetectable
5eexP-4xoxA:
undetectable
5eexO-4xoxA:
11.39
5eexP-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5eeyO-4xoxA:
undetectable
5eeyP-4xoxA:
undetectable
5eeyO-4xoxA:
11.39
5eeyP-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5eezO-4xoxA:
undetectable
5eezP-4xoxA:
undetectable
5eezO-4xoxA:
11.39
5eezP-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5ef0O-4xoxA:
undetectable
5ef0P-4xoxA:
undetectable
5ef0O-4xoxA:
11.39
5ef0P-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5ef1O-4xoxA:
undetectable
5ef1P-4xoxA:
undetectable
5ef1O-4xoxA:
11.39
5ef1P-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5ef2O-4xoxA:
undetectable
5ef2P-4xoxA:
undetectable
5ef2O-4xoxA:
11.39
5ef2P-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 10 GLY A  16
ILE A  12
THR A 328
SER A 230
ALA A 331
None
1.20A 5ef3O-4xoxA:
undetectable
5ef3P-4xoxA:
undetectable
5ef3O-4xoxA:
11.39
5ef3P-4xoxA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 ILE A 150
GLY A 152
ASP A  96
ARG A 151
ALA A 171
None
1.12A 5h5fA-4xoxA:
1.3
5h5fA-4xoxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
3 / 3 VAL A 238
LYS A   2
MET A   1
None
1.06A 5nknA-4xoxA:
undetectable
5nknA-4xoxA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
3 / 3 THR A 344
MET A 346
HIS A 349
None
1.02A 5uunA-4xoxA:
undetectable
5uunA-4xoxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 9 ALA A  71
SER A 104
GLY A 188
GLY A 186
SER A 141
None
1.21A 6bklE-4xoxA:
undetectable
6bklF-4xoxA:
undetectable
6bklG-4xoxA:
undetectable
6bklH-4xoxA:
undetectable
6bklE-4xoxA:
4.27
6bklF-4xoxA:
4.27
6bklG-4xoxA:
4.27
6bklH-4xoxA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
5 / 12 GLY A 329
VAL A  22
GLY A 233
GLY A 232
ILE A  15
None
0.88A 6dj1A-4xoxA:
undetectable
6dj1A-4xoxA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio
cholerae)
4 / 6 SER A 137
GLN A 112
GLU A 189
THR A 163
None
1.41A 6djzA-4xoxA:
undetectable
6djzA-4xoxA:
22.93