SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 428
LEU A 431
GLY A 432
ALA A 438
LEU A 441
 None
 1.13A 1gs4A-4xpdA:
undetectable		 1gs4A-4xpdA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 ALA A  80
VAL A  77
ALA A  58
HIS A  53
 None
 1.17A 1q23A-4xpdA:
undetectable		 1q23A-4xpdA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 ALA A  80
VAL A  77
ALA A  58
HIS A  53
 None
 1.22A 1q23K-4xpdA:
undetectable		 1q23K-4xpdA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 368
LEU A 363
SER A 360
LEU A 397
 None
 1.19A 1ya3A-4xpdA:
undetectable		 1ya3A-4xpdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 813
SER A 836
LEU A 798
LEU A 830
 None
 1.11A 1yajA-4xpdA:
undetectable		 1yajA-4xpdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  98
THR A 115
ALA A 116
ALA A 117
 None
 0.46A 2ej3A-4xpdA:
undetectable		 2ej3A-4xpdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 553
ALA A 671
ILE A 488
LYS A 549
 None
 0.79A 2othA-4xpdA:
undetectable		 2othA-4xpdA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 383
THR A 386
ALA A 409
ALA A 410
 None
 1.16A 3ns1C-4xpdA:
undetectable		 3ns1C-4xpdA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 421
LEU A 463
ARG A 445
 None
 0.81A 3sufB-4xpdA:
undetectable		 3sufB-4xpdA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  65
TYR A 100
TYR A  31
LEU A  40
 None
 1.35A 3uzzB-4xpdA:
undetectable		 3uzzB-4xpdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 553
ALA A 670
ILE A 488
LYS A 549
 None
 1.41A 4eixA-4xpdA:
undetectable		 4eixA-4xpdA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 553
ALA A 671
ILE A 488
LYS A 549
 None
 0.87A 4eixA-4xpdA:
undetectable		 4eixA-4xpdA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 462
GLY A 444
THR A 458
ARG A 445
 None
 0.97A 4k87A-4xpdA:
undetectable		 4k87A-4xpdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA406_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 819
PHE A 765
ARG A 723
MET A 692
 None
 1.48A 4kf9A-4xpdA:
0.1		 4kf9A-4xpdA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 751
ASP A 717
PHE A 720
 None
 0.97A 4xeyA-4xpdA:
undetectable		 4xeyA-4xpdA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 751
ASP A 717
PHE A 720
 None
 0.91A 4xeyB-4xpdA:
undetectable		 4xeyB-4xpdA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 618
GLN A 617
ARG A 723
 None
 0.99A 5ewzB-4xpdA:
6.2		 5ewzB-4xpdA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 618
GLN A 617
ARG A 723
 None
 0.95A 5m35B-4xpdA:
undetectable		 5m35B-4xpdA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 618
GLN A 617
ARG A 723
 None
 0.91A 5m36A-4xpdA:
undetectable		 5m36A-4xpdA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 348
ALA A 403
GLN A 336
LEU A 337
VAL A 367
 None
 1.14A 5tudD-4xpdA:
undetectable		 5tudD-4xpdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 618
GLN A 617
ARG A 723
 None
 0.96A 6fn9A-4xpdA:
4.1		 6fn9A-4xpdA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 618
GLN A 617
ARG A 723
 None
 0.99A 6fnaB-4xpdA:
3.8		 6fnaB-4xpdA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1
(Saccharomyces
cerevisiae) 		3 / 3 MET A 618
GLN A 617
ARG A 723
 None
 0.95A 6fnbA-4xpdA:
3.8		 6fnbA-4xpdA:
14.79