SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_B_CTXB2_1 (CES1 PROTEIN)	4xpf	ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN (Mus musculus)	5 / 12	GLY H 8 GLY H 9 LEU H 18 SER H 17 LEU H 115	None	1.32A	1ya4B-4xpfH: undetectable	1ya4B-4xpfH: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F9W_A_PAUA6002_0 (PANTOTHENATE KINASE)	4xpf	ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN (Mus musculus)	4 / 8	ARG H 56 GLY H 54 ARG H 72 ILE H 51	None	0.95A	2f9wA-4xpfH: undetectable 2f9wB-4xpfH: undetectable	2f9wA-4xpfH: 22.64 2f9wB-4xpfH: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KOT_A_ANWA99_0 (PROTEIN S100-A13)	4xpf	ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN (Mus musculus)	4 / 7	VAL H 64 THR H 65 PHE H 68 THR H 69	None	1.15A	2kotA-4xpfH: undetectable	2kotA-4xpfH: 14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4xpf	ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN (Mus musculus)	4 / 6	LYS H 149 LEU H 183 PHE H 172 LEU H 158	None	0.94A	5w97C-4xpfH: undetectable 5w97J-4xpfH: undetectable	5w97C-4xpfH: 21.11 5w97J-4xpfH: 15.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YA4_B_CTXB2_1","CES1 PROTEIN","4xpf","ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN","Mus musculus",5,"GLY H   8;GLY H   9;LEU H  18;SER H  17;LEU H 115","None","1.32A","1ya4B-4xpfH:undetectable","1ya4B-4xpfH:19.23"],["2F9W_A_PAUA6002_0","PANTOTHENATE KINASE","4xpf","ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN","Mus musculus",4,"ARG H  56;GLY H  54;ARG H  72;ILE H  51","None","0.95A","2f9wA-4xpfH:undetectable;2f9wB-4xpfH:undetectable","2f9wA-4xpfH:22.64;2f9wB-4xpfH:22.64"],["2KOT_A_ANWA99_0","PROTEIN S100-A13","4xpf","ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN","Mus musculus",4,"VAL H  64;THR H  65;PHE H  68;THR H  69","None","1.15A","2kotA-4xpfH:undetectable","2kotA-4xpfH:14.94"],["5W97_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4xpf","ANTIBODY FRAGMENT LIGHT CHAIN-PROTEIN, 9D5-LIGHT CHAIN","Mus musculus",4,"LYS H 149;LEU H 183;PHE H 172;LEU H 158","None","0.94A","5w97C-4xpfH:undetectable;5w97J-4xpfH:undetectable","5w97C-4xpfH:21.11;5w97J-4xpfH:15.09"]]