SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4xpm PROTEIN MEH1
UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 168
ILE A 164
THR B  25
THR B  12
 None
 0.99A 1sbrB-4xpmA:
undetectable		 1sbrB-4xpmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4xpm UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		4 / 7 VAL B  27
GLY B  26
THR B  12
ASP B   8
 None
 0.87A 2a1mA-4xpmB:
undetectable		 2a1mA-4xpmB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xpm PROTEIN MEH1
UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		5 / 12 GLY B  26
ALA B  14
ILE A 164
LEU A 160
LEU A 157
 None
 0.77A 3adxB-4xpmB:
undetectable		 3adxB-4xpmB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xpm UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		5 / 9 GLY B  28
GLN B  30
ASP B  34
ILE B  35
VAL B  21
 None
 1.39A 3fi0K-4xpmB:
undetectable		 3fi0K-4xpmB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xpm UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		5 / 9 GLY B  28
GLN B  30
ASP B  34
ILE B  35
VAL B  21
 None
 1.32A 3fi0O-4xpmB:
undetectable		 3fi0O-4xpmB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xpm PROTEIN MEH1
UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		5 / 11 GLY B  26
ALA B  14
ILE A 164
LEU A 160
LEU A 157
 None
 0.79A 4xumB-4xpmB:
undetectable		 4xumB-4xpmB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 4xpm UNCHARACTERIZED
PROTEIN YCR075W-A
(Saccharomyces
cerevisiae) 		5 / 9 GLY B  28
GLN B  30
ASP B  34
ILE B  35
VAL B  21
 None
 1.33A 5v0iA-4xpmB:
undetectable		 5v0iA-4xpmB:
13.39