SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
3 / 3 TRP A 468
ALA A 500
VAL A 498
None
0.91A 1c4dC-4xprA:
undetectable
1c4dD-4xprA:
undetectable
1c4dC-4xprA:
3.37
1c4dD-4xprA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 5 TYR A 517
LEU A 225
VAL A 706
ASP A 666
None
1.45A 1dz6A-4xprA:
undetectable
1dz6A-4xprA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 10 VAL A 194
PHE A  71
VAL A 203
VAL A 201
LEU A  89
None
1.03A 1fe2A-4xprA:
undetectable
1fe2A-4xprA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 6 TYR A 599
ASP A 628
ASN A 657
GLU A 651
None
1.33A 1rjdA-4xprA:
undetectable
1rjdA-4xprA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 6 TYR A 599
ASP A 628
ASN A 657
GLU A 651
None
1.33A 1rjdB-4xprA:
undetectable
1rjdB-4xprA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 8 TYR A 100
PHE A 450
PHE A 137
ALA A 212
EDO  A1001 (-4.5A)
EDO  A1001 (-4.8A)
None
None
1.13A 1x8vA-4xprA:
undetectable
1x8vA-4xprA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 8 PRO A 633
MET A 634
GLY A 710
LEU A 664
None
EDO  A1004 ( 4.8A)
None
None
0.91A 1ya4A-4xprA:
undetectable
1ya4A-4xprA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
3 / 3 TRP A 455
THR A 131
TYR A 123
None
0.91A 2a3aB-4xprA:
3.6
2a3aB-4xprA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 6 VAL A 359
SER A 360
LEU A 265
PHE A 262
None
1.27A 2f8dA-4xprA:
undetectable
2f8dA-4xprA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 7 TYR A 429
GLY A 361
THR A 413
ASN A 303
None
0.71A 2g70A-4xprA:
undetectable
2g70A-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 7 TYR A 429
GLY A 361
THR A 413
ASN A 303
None
0.68A 2g70B-4xprA:
undetectable
2g70B-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 LEU A 118
ASP A  49
VAL A 194
VAL A 156
ILE A 154
None
0.93A 2pynA-4xprA:
undetectable
2pynA-4xprA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 GLY A 696
GLY A 630
GLY A 660
GLU A 661
VAL A 626
None
1.00A 2wa2B-4xprA:
undetectable
2wa2B-4xprA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 6 LEU A 536
ILE A 210
ARG A 522
PRO A 529
EDO  A1001 ( 4.8A)
None
None
None
1.10A 2ygoA-4xprA:
undetectable
2ygoA-4xprA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
3 / 3 TRP A 330
VAL A 398
ARG A 343
None
0.91A 3b0wA-4xprA:
undetectable
3b0wA-4xprA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 LEU A 118
ASP A  49
VAL A 194
VAL A 156
ILE A 154
None
0.93A 3d20B-4xprA:
undetectable
3d20B-4xprA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 LEU A 118
ASP A  49
VAL A 194
VAL A 156
ILE A 154
None
0.92A 3jvyB-4xprA:
undetectable
3jvyB-4xprA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 5 SER A 182
ARG A 163
GLY A 161
GLU A 191
None
1.32A 3k9fA-4xprA:
2.1
3k9fB-4xprA:
2.1
3k9fC-4xprA:
undetectable
3k9fA-4xprA:
21.67
3k9fB-4xprA:
21.67
3k9fC-4xprA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 8 ASP A 666
LEU A 650
LEU A 664
SER A 699
None
0.96A 3lm8A-4xprA:
3.1
3lm8C-4xprA:
undetectable
3lm8A-4xprA:
13.37
3lm8C-4xprA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 7 TYR A  88
VAL A 203
VAL A  42
ILE A 148
None
1.08A 3mssB-4xprA:
undetectable
3mssB-4xprA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 9 ILE A 442
PHE A 450
THR A 131
GLU A 566
GLY A 101
None
EDO  A1001 (-4.8A)
None
None
None
1.31A 3nxuB-4xprA:
undetectable
3nxuB-4xprA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 8 PHE A 477
ALA A 481
PHE A 505
ALA A 506
None
0.86A 3t3sF-4xprA:
undetectable
3t3sF-4xprA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 11 VAL A  42
ALA A  40
LEU A  80
LEU A 193
VAL A 203
None
1.16A 3zosA-4xprA:
undetectable
3zosB-4xprA:
undetectable
3zosA-4xprA:
18.71
3zosB-4xprA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 8 TYR A 274
TRP A 305
VAL A 417
ILE A 306
None
EDO  A1005 (-4.6A)
None
None
1.15A 4aftD-4xprA:
undetectable
4aftE-4xprA:
undetectable
4aftD-4xprA:
15.35
4aftE-4xprA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
3 / 3 TYR A 224
THR A 413
GLU A 675
None
0.56A 4df3A-4xprA:
undetectable
4df3A-4xprA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
3 / 3 TYR A 224
THR A 413
GLU A 675
None
0.60A 4df3B-4xprA:
undetectable
4df3B-4xprA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
3 / 3 GLY A 361
SER A 360
TRP A 229
None
0.69A 4e7cD-4xprA:
undetectable
4e7cD-4xprA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 7 ASP A 127
GLN A 107
ASN A 105
ILE A 446
None
1.22A 4ii8A-4xprA:
undetectable
4ii8A-4xprA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 5 LEU A  50
GLY A 422
ILE A 154
GLN A 392
None
1.15A 4ma8C-4xprA:
undetectable
4ma8C-4xprA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 VAL A 203
TYR A 144
VAL A 139
PHE A  71
GLY A 205
None
1.20A 4mm4B-4xprA:
undetectable
4mm4B-4xprA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 VAL A 359
TYR A 429
GLY A 361
ILE A 306
LEU A 350
None
1.04A 4o5fA-4xprA:
undetectable
4o5fB-4xprA:
undetectable
4o5fA-4xprA:
17.78
4o5fB-4xprA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 LEU A 350
VAL A 359
TYR A 429
GLY A 361
ILE A 306
None
1.03A 4o5fA-4xprA:
undetectable
4o5fB-4xprA:
undetectable
4o5fA-4xprA:
17.78
4o5fB-4xprA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 PRO A 267
GLU A 266
ASN A 303
GLY A 415
TYR A 429
None
EDO  A1005 (-2.9A)
None
None
None
1.45A 4oadA-4xprA:
undetectable
4oadA-4xprA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 11 LEU A  89
PHE A 147
GLY A 198
LEU A  80
ALA A  40
None
1.21A 4wnuA-4xprA:
undetectable
4wnuA-4xprA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 VAL A 359
TYR A 429
GLY A 361
ILE A 306
LEU A 350
None
1.04A 5b8hA-4xprA:
undetectable
5b8hB-4xprA:
undetectable
5b8hA-4xprA:
19.09
5b8hB-4xprA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 LEU A 350
VAL A 359
TYR A 429
GLY A 361
ILE A 306
None
1.06A 5b8hA-4xprA:
undetectable
5b8hB-4xprA:
undetectable
5b8hA-4xprA:
19.09
5b8hB-4xprA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 11 VAL A 201
VAL A 199
TYR A 138
ILE A 154
LEU A  89
None
0.98A 5e4dB-4xprA:
undetectable
5e4dB-4xprA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 11 SER A  83
TYR A  88
SER A  79
GLU A  81
GLU A 191
None
1.26A 5iqdA-4xprA:
0.0
5iqdA-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 11 SER A  83
TYR A  88
SER A  79
GLU A  81
GLU A 191
None
1.25A 5iqdB-4xprA:
0.2
5iqdB-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 11 SER A  83
TYR A  88
SER A  79
GLU A  81
GLU A 191
None
1.28A 5iqdD-4xprA:
1.5
5iqdD-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
4 / 6 GLY A 424
THR A 425
SER A 426
GLY A 222
None
0.80A 5k4pA-4xprA:
undetectable
5k4pA-4xprA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 12 LEU A 302
MET A 482
VAL A 263
PHE A 291
GLY A 268
None
1.43A 6brdA-4xprA:
undetectable
6brdA-4xprA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)
4xpr ALPHA-GLUCOSIDASE
(Pseudopedobacter
saltans)
5 / 9 SER A  83
TYR A  88
SER A  79
GLU A  81
GLU A 191
None
1.30A 6c5uB-4xprA:
0.0
6c5uB-4xprA:
18.45