SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		5 / 12 GLY A 106
GLY A 177
ILE A 174
ALA A 185
SER A 108
 None
 1.19A 1ri4A-4xpuA:
undetectable		 1ri4A-4xpuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		5 / 11 THR A 127
ALA A  32
GLY A  33
ALA A  34
MET A  49
 None
 1.06A 2xh9A-4xpuA:
undetectable		 2xh9A-4xpuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		4 / 6 VAL A  36
VAL A 102
PHE A 119
GLU A  82
 None
 1.42A 3n61A-4xpuA:
undetectable
3n61B-4xpuA:
undetectable		 3n61A-4xpuA:
20.28
3n61B-4xpuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		4 / 5 HIS A 109
SER A 108
ARG A 197
ASP A 103
 None
 1.12A 3okxA-4xpuA:
undetectable		 3okxA-4xpuA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		3 / 3 PHE A  77
SER A  79
GLN A  10
 None
 0.96A 3smtA-4xpuA:
undetectable		 3smtA-4xpuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		4 / 7 LEU A 152
ALA A 175
LEU A 159
SER A 117
 None
 1.11A 4iklA-4xpuA:
undetectable
4iklB-4xpuA:
undetectable		 4iklA-4xpuA:
18.89
4iklB-4xpuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4xpu ENDONUCLEASE V
(Escherichia
coli) 		5 / 12 VAL A 102
ALA A  48
PRO A 126
ALA A  34
GLY A  33
 None
 1.17A 5tzoA-4xpuA:
undetectable		 5tzoA-4xpuA:
21.10