SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 12 HIS A  77
PHE A  17
HIS A  81
HIS A 117
ASP A 122
 FE2  A 201 (-3.4A)
None
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 ( 2.6A)
 1.32A 1a4lA-4xpxA:
undetectable		 1a4lA-4xpxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 12 HIS A  77
PHE A  17
HIS A  81
HIS A 117
ASP A 122
 FE2  A 201 (-3.4A)
None
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 ( 2.6A)
 1.29A 1a4lC-4xpxA:
undetectable		 1a4lC-4xpxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.33A 1v7zA-4xpxA:
undetectable		 1v7zA-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.16A 1v7zA-4xpxA:
undetectable		 1v7zA-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.35A 1v7zB-4xpxA:
undetectable		 1v7zB-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.17A 1v7zB-4xpxA:
undetectable		 1v7zB-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.34A 1v7zD-4xpxA:
undetectable		 1v7zD-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.15A 1v7zD-4xpxA:
undetectable		 1v7zD-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 8 HIS A  81
GLU A  62
HIS A  77
ALA A  18
 FE2  A 201 (-3.4A)
FE2  A 201 ( 2.6A)
FE2  A 201 (-3.4A)
None
 1.00A 2bnnA-4xpxA:
undetectable
2bnnB-4xpxA:
undetectable		 2bnnA-4xpxA:
22.39
2bnnB-4xpxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 7 ALA A  18
TYR A 125
MET A  57
HIS A  22
 None
None
None
FE2  A 202 (-3.3A)
 1.11A 2pncA-4xpxA:
undetectable		 2pncA-4xpxA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 11 HIS A  22
ILE A  25
HIS A  58
HIS A  81
HIS A 117
 FE2  A 202 (-3.3A)
None
FE2  A 202 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
 1.21A 2zweA-4xpxA:
undetectable
2zweB-4xpxA:
undetectable		 2zweA-4xpxA:
17.65
2zweB-4xpxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.31A 3a6jA-4xpxA:
undetectable		 3a6jA-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.18A 3a6jA-4xpxA:
undetectable		 3a6jA-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.31A 3a6jE-4xpxA:
undetectable		 3a6jE-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.18A 3a6jE-4xpxA:
undetectable		 3a6jE-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.33A 3a6jF-4xpxA:
undetectable		 3a6jF-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 8 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.18A 3a6jF-4xpxA:
undetectable		 3a6jF-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 11 VAL A  15
HIS A 117
HIS A  77
HIS A  81
HIS A  58
 None
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 (-3.4A)
 1.45A 4c1fA-4xpxA:
undetectable
4c1fB-4xpxA:
undetectable		 4c1fA-4xpxA:
17.60
4c1fB-4xpxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 8 ASP A 122
PHE A  59
VAL A  55
HIS A  22
 FE2  A 202 ( 2.6A)
None
None
FE2  A 202 (-3.3A)
 0.86A 4f5zA-4xpxA:
undetectable		 4f5zA-4xpxA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 7 HIS A  77
HIS A 117
HIS A  22
HIS A  58
 FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 (-3.3A)
FE2  A 202 (-3.4A)
 0.87A 4p6sA-4xpxA:
undetectable		 4p6sA-4xpxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 7 HIS A  77
HIS A 117
HIS A  22
HIS A  58
 FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 (-3.3A)
FE2  A 202 (-3.4A)
 0.85A 4p6sB-4xpxA:
undetectable		 4p6sB-4xpxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 12 THR A  13
VAL A  15
GLU A  63
ILE A  25
HIS A  22
 None
None
None
None
FE2  A 202 (-3.3A)
 1.45A 4s0vA-4xpxA:
4.3		 4s0vA-4xpxA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 12 ALA A  75
ASP A 122
GLN A  21
SER A  61
GLU A  63
 None
FE2  A 202 ( 2.6A)
None
None
None
 1.25A 5hfjF-4xpxA:
undetectable		 5hfjF-4xpxA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 6 VAL A  55
HIS A  58
HIS A 117
LEU A 114
 None
FE2  A 202 (-3.4A)
FE2  A 201 (-3.4A)
None
 0.96A 5hrqH-4xpxA:
undetectable
5hrqK-4xpxA:
undetectable
5hrqL-4xpxA:
undetectable		 5hrqH-4xpxA:
16.22
5hrqK-4xpxA:
8.47
5hrqL-4xpxA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 7 HIS A  77
HIS A 117
HIS A  22
HIS A  58
 FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 (-3.3A)
FE2  A 202 (-3.4A)
 0.89A 5i3aA-4xpxA:
undetectable		 5i3aA-4xpxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		4 / 7 HIS A  77
HIS A 117
HIS A  22
HIS A  58
 FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 202 (-3.3A)
FE2  A 202 (-3.4A)
 0.87A 5i3aB-4xpxA:
undetectable		 5i3aB-4xpxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 11 HIS A  22
ILE A  25
HIS A  58
HIS A  81
HIS A 117
 FE2  A 202 (-3.3A)
None
FE2  A 202 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
 1.14A 5z0gA-4xpxA:
undetectable
5z0gB-4xpxA:
undetectable		 5z0gA-4xpxA:
16.41
5z0gB-4xpxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 4xpx BACTERIOHEMERYTHRIN
(Methylococcus
capsulatus) 		5 / 11 HIS A  22
ILE A  25
HIS A  58
HIS A  81
HIS A 117
 FE2  A 202 (-3.3A)
None
FE2  A 202 (-3.4A)
FE2  A 201 (-3.4A)
FE2  A 201 (-3.4A)
 1.15A 5z0iA-4xpxA:
undetectable
5z0iB-4xpxA:
undetectable		 5z0iA-4xpxA:
16.41
5z0iB-4xpxA:
21.49