SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 4 GLU A 238
MET A 292
LEU A 165
SER A 166
 None
 1.43A 1ee2B-4xpzA:
undetectable		 1ee2B-4xpzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 377
PRO A 355
HIS A 177
GLU A 316
 None
PG4  A 603 (-4.5A)
None
None
 1.01A 1jtvA-4xpzA:
3.0		 1jtvA-4xpzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 356
ASN A 195
LEU A 199
TRP A 187
 None
 1.22A 1ru9H-4xpzA:
undetectable
1ru9L-4xpzA:
undetectable		 1ru9H-4xpzA:
21.14
1ru9L-4xpzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 356
ASN A 195
LEU A 199
TRP A 187
 None
 1.26A 1ruaH-4xpzA:
undetectable
1ruaL-4xpzA:
undetectable		 1ruaH-4xpzA:
21.14
1ruaL-4xpzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 282
ILE A 168
LEU A 167
SER A 166
 None
 0.91A 2byoA-4xpzA:
undetectable		 2byoA-4xpzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
 0.69A 3ko0B-4xpzA:
undetectable		 3ko0B-4xpzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
 0.63A 3ko0S-4xpzA:
undetectable		 3ko0S-4xpzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 LYS A 425
VAL A 295
ILE A 421
ARG A 299
 None
 1.27A 3pyyB-4xpzA:
undetectable		 3pyyB-4xpzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 9 PHE A 264
LEU A 171
VAL A 253
LEU A 230
ILE A 257
 None
AF3  A 601 (-4.0A)
None
None
None
 1.04A 3tbgD-4xpzA:
undetectable		 3tbgD-4xpzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 PRO A 355
LEU A 376
LEU A 377
ILE A 321
 PG4  A 603 (-4.5A)
None
None
None
 0.94A 3u5jA-4xpzA:
undetectable		 3u5jA-4xpzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 PRO A 355
LEU A 376
LEU A 377
ILE A 321
 PG4  A 603 (-4.5A)
None
None
None
 0.85A 3u5kA-4xpzA:
undetectable		 3u5kA-4xpzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 PRO A 355
LEU A 376
LEU A 377
ILE A 321
 PG4  A 603 (-4.5A)
None
None
None
 0.98A 3u5kB-4xpzA:
undetectable		 3u5kB-4xpzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 PRO A 355
LEU A 376
LEU A 377
ILE A 321
 PG4  A 603 (-4.5A)
None
None
None
 0.94A 3u5kC-4xpzA:
undetectable		 3u5kC-4xpzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 PRO A 355
LEU A 376
LEU A 377
ILE A 321
 PG4  A 603 (-4.5A)
None
None
None
 0.93A 3u5kD-4xpzA:
undetectable		 3u5kD-4xpzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 497
LEU A 500
LEU A 504
ILE A 451
PHE A 458
 None
 1.08A 4a7aB-4xpzA:
undetectable		 4a7aB-4xpzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 429
LEU A 434
ALA A 455
LEU A 504
VAL A 495
 None
 1.13A 4p65C-4xpzA:
undetectable
4p65D-4xpzA:
undetectable
4p65J-4xpzA:
undetectable
4p65L-4xpzA:
undetectable		 4p65C-4xpzA:
4.35
4p65D-4xpzA:
5.85
4p65J-4xpzA:
5.85
4p65L-4xpzA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 394
ASN A 416
PRO A 422
VAL A 294
ILE A 310
 None
 1.10A 4rvgA-4xpzA:
undetectable		 4rvgA-4xpzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS A 414
GLY A 410
ASN A 411
HIS A 412
 None
 1.27A 5a5zC-4xpzA:
undetectable		 5a5zC-4xpzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 391
LEU A 387
MET A 424
TYR A 398
 None
 1.02A 5uc3A-4xpzA:
undetectable		 5uc3A-4xpzA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
AF3  A 601 ( 4.0A)
 1.42A 5vcvA-4xpzA:
undetectable		 5vcvA-4xpzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 9 GLN A 339
SER A 326
PHE A 328
LEU A 277
ASN A 340
 None
 1.50A 6ftpA-4xpzA:
undetectable
6ftpB-4xpzA:
undetectable		 6ftpA-4xpzA:
10.70
6ftpB-4xpzA:
10.78