SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xq2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 10 ASP A 313
ARG A 310
GLU A 309
ALA A 335
PRO A 341
 None
 1.45A 1mskA-4xq2A:
undetectable		 1mskA-4xq2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 11 LEU A  57
LEU A 244
PRO A 178
VAL A 179
VAL A 211
 None
 1.25A 2po5B-4xq2A:
2.8		 2po5B-4xq2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 12 LEU A  57
LEU A 244
PRO A 178
VAL A 179
VAL A 211
 None
 1.27A 2qd4A-4xq2A:
2.2		 2qd4A-4xq2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4xq2 CALE6
(Micromonospora
echinospora) 		4 / 8 PRO A 125
PRO A 283
HIS A 285
VAL A 287
 None
 0.86A 3em0B-4xq2A:
undetectable		 3em0B-4xq2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 12 VAL A 205
LEU A  61
THR A 196
ILE A 199
ALA A 200
 None
None
LLP  A 197 ( 3.5A)
None
LLP  A 197 ( 4.7A)
 0.94A 3mdvB-4xq2A:
undetectable		 3mdvB-4xq2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 9 ARG A 161
ILE A 128
ALA A 162
LEU A 122
VAL A 169
 None
 1.23A 3o01A-4xq2A:
undetectable
3o01B-4xq2A:
undetectable		 3o01A-4xq2A:
22.59
3o01B-4xq2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4xq2 CALE6
(Micromonospora
echinospora) 		3 / 3 HIS A 339
GLU A 332
ASN A 147
 None
None
MES  A 401 ( 4.8A)
 1.02A 4bupB-4xq2A:
undetectable		 4bupB-4xq2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 11 PHE A  73
ALA A  78
ALA A  81
ALA A  80
VAL A 190
 None
 1.16A 4j6cA-4xq2A:
undetectable		 4j6cA-4xq2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 11 GLY A 187
ALA A 188
ASP A 189
THR A 144
VAL A 171
 None
None
CL  A 405 ( 4.4A)
None
None
 0.91A 4l1aA-4xq2A:
undetectable		 4l1aA-4xq2A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 12 LEU A 210
SER A  95
THR A  82
GLY A 102
LEU A 106
 None
 1.31A 5m50E-4xq2A:
2.2		 5m50E-4xq2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4xq2 CALE6
(Micromonospora
echinospora) 		4 / 7 VAL A 255
ARG A 259
VAL A 262
GLY A 278
 None
 0.97A 5x80C-4xq2A:
undetectable
5x80D-4xq2A:
undetectable		 5x80C-4xq2A:
17.75
5x80D-4xq2A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 12 LEU A 139
VAL A 155
THR A 103
LEU A 106
ALA A  80
 None
 1.17A 6djzC-4xq2A:
undetectable		 6djzC-4xq2A:
22.52