SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  67
PHE A  68
LEU A 104
THR A 315
LEU A 113
 FMN  A 401 (-3.2A)
None
FMN  A 401 ( 4.3A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.6A)
 1.46A 1a8uA-4xq6A:
undetectable		 1a8uA-4xq6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  65
ILE A 294
GLY A 316
ILE A 318
THR A 242
 FMN  A 401 (-3.3A)
None
None
None
CL  A 403 (-3.1A)
 0.96A 1c6yA-4xq6A:
undetectable		 1c6yA-4xq6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 115
ASN A 176
ASN A 241
THR A 242
 FMN  A 401 ( 3.5A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.6A)
CL  A 403 (-3.1A)
 0.75A 1h7xA-4xq6A:
32.4		 1h7xA-4xq6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 115
ASN A 176
ASN A 241
THR A 242
 FMN  A 401 ( 3.5A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.6A)
CL  A 403 (-3.1A)
 0.74A 1h7xB-4xq6A:
32.4		 1h7xB-4xq6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 115
ASN A 176
ASN A 241
THR A 242
 FMN  A 401 ( 3.5A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.6A)
CL  A 403 (-3.1A)
 0.75A 1h7xC-4xq6A:
32.3		 1h7xC-4xq6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 115
ASN A 176
ASN A 241
THR A 242
 FMN  A 401 ( 3.5A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.6A)
CL  A 403 (-3.1A)
 0.75A 1h7xD-4xq6A:
32.2		 1h7xD-4xq6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.94A 1hpvA-4xq6A:
undetectable		 1hpvA-4xq6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 8 SER A 179
GLY A 145
THR A  90
GLY A 118
 FMN  A 401 (-3.6A)
None
FMN  A 401 (-4.0A)
CL  A 402 ( 3.8A)
 0.83A 1jr1B-4xq6A:
18.4		 1jr1B-4xq6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  64
PHE A  83
HIS A 329
ILE A 328
ILE A 332
 None
 1.42A 2efjA-4xq6A:
undetectable		 2efjA-4xq6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.93A 2ienB-4xq6A:
undetectable		 2ienB-4xq6A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  62
PRO A  61
LEU A 311
ILE A 294
 None
 0.75A 2qd4A-4xq6A:
undetectable		 2qd4A-4xq6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  58
GLU A  87
LEU A 310
ALA A 287
PHE A  54
 None
 1.41A 3apxA-4xq6A:
undetectable		 3apxA-4xq6A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 307
HIS A 329
ILE A 332
LEU A 336
LEU A 311
 None
 0.94A 3cs8A-4xq6A:
undetectable		 3cs8A-4xq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 266
ALA A 268
ALA A 271
THR A 315
 None
None
None
FMN  A 401 (-3.6A)
 0.83A 3dtuC-4xq6A:
undetectable
3dtuD-4xq6A:
undetectable		 3dtuC-4xq6A:
20.88
3dtuD-4xq6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  65
ILE A 294
GLY A 316
ILE A 318
THR A 242
 FMN  A 401 (-3.3A)
None
None
None
CL  A 403 (-3.1A)
 0.90A 3el4B-4xq6A:
undetectable		 3el4B-4xq6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  65
ILE A 294
GLY A 316
ILE A 318
THR A 242
 FMN  A 401 (-3.3A)
None
None
None
CL  A 403 (-3.1A)
 0.98A 3el9B-4xq6A:
undetectable		 3el9B-4xq6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  53
LEU A 275
SER A  51
GLY A  63
LEU A  62
 None
 1.30A 3j6pB-4xq6A:
undetectable		 3j6pB-4xq6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.86A 3pwmB-4xq6A:
undetectable		 3pwmB-4xq6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 278
TYR A 279
ARG A 281
LEU A 288
 None
 0.84A 3rd0A-4xq6A:
undetectable		 3rd0A-4xq6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  62
PRO A  61
LEU A 311
ILE A 294
 None
 0.76A 4f4dB-4xq6A:
undetectable		 4f4dB-4xq6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 8 SER A 179
GLY A 145
THR A  90
GLY A 118
 FMN  A 401 (-3.6A)
None
FMN  A 401 (-4.0A)
CL  A 402 ( 3.8A)
 0.85A 4fo4B-4xq6A:
19.1		 4fo4B-4xq6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  62
PRO A  61
LEU A 311
ILE A 294
 None
 0.81A 4klrA-4xq6A:
undetectable		 4klrA-4xq6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  80
ALA A 325
ALA A  60
GLY A  84
LEU A  62
 None
 1.00A 4oaeA-4xq6A:
undetectable		 4oaeA-4xq6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 295
THR A 315
THR A 243
LEU A 249
 None
FMN  A 401 (-3.6A)
None
None
 0.98A 4pfjA-4xq6A:
undetectable		 4pfjA-4xq6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 172
GLU A  87
LEU A 210
GLN A 312
 None
 1.33A 4qztB-4xq6A:
undetectable		 4qztB-4xq6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 5 THR A 147
ALA A  93
THR A  92
HIS A  94
 None
 1.28A 5ecmA-4xq6A:
1.7		 5ecmA-4xq6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.89A 5t8hA-4xq6A:
undetectable		 5t8hA-4xq6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  50
ILE A 332
ALA A 333
LEU A 336
 None
 0.82A 5te8B-4xq6A:
undetectable		 5te8B-4xq6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  66
GLY A 313
GLY A  72
LEU A 131
LEU A  75
 FMN  A 401 (-3.6A)
FMN  A 401 (-3.3A)
None
None
None
 1.11A 5wwsA-4xq6A:
undetectable		 5wwsA-4xq6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 212
ASN A 176
SER A 179
 FMN  A 401 (-2.9A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.6A)
 1.13A 5yw0A-4xq6A:
undetectable		 5yw0A-4xq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 141
VAL A 209
ILE A 129
GLY A  72
ALA A 124
 None
 1.16A 6c2mB-4xq6A:
undetectable		 6c2mB-4xq6A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.96A 6dgxA-4xq6A:
undetectable		 6dgxA-4xq6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.92A 6dh3A-4xq6A:
undetectable		 6dh3A-4xq6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  63
GLY A 141
ILE A  88
PRO A 136
ILE A 138
 None
 0.82A 6difB-4xq6A:
undetectable		 6difB-4xq6A:
13.08