SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.15A 1bsxA-4xq7A:
undetectable		 1bsxA-4xq7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.15A 1bsxB-4xq7A:
undetectable		 1bsxB-4xq7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.16A 1xzxX-4xq7A:
undetectable		 1xzxX-4xq7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.16A 2h77A-4xq7A:
undetectable		 2h77A-4xq7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 243
THR A 262
ALA A 326
ALA A 323
ILE A 273
 None
 1.13A 2nyrA-4xq7A:
undetectable		 2nyrA-4xq7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 191
ALA A 180
PHE A  94
SER A  93
TYR A 157
 CME  A 188 ( 4.4A)
None
CME  A 188 ( 3.6A)
None
None
 1.33A 3apwB-4xq7A:
undetectable		 3apwB-4xq7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 153
LEU A 123
GLN A  46
ARG A 143
VAL A 151
 None
 1.15A 3ix9B-4xq7A:
undetectable		 3ix9B-4xq7A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 9 LEU A  34
ILE A 140
LEU A 118
ILE A 149
PHE A  43
 None
 1.08A 4kukA-4xq7A:
undetectable		 4kukA-4xq7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.11A 4lnwA-4xq7A:
undetectable		 4lnwA-4xq7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.13A 4lnxA-4xq7A:
undetectable		 4lnxA-4xq7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  62
ARG A  45
ARG A  60
 None
 0.97A 4yiaB-4xq7A:
undetectable		 4yiaB-4xq7A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 PRO A 306
GLU A 299
LEU A 267
TYR A 317
 None
 0.97A 5igiA-4xq7A:
undetectable		 5igiA-4xq7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 5 PRO A 309
ALA A 307
LYS A 187
GLN A 195
 None
None
CME  A 188 ( 1.1A)
CME  A 188 ( 4.4A)
 1.41A 5odcA-4xq7A:
undetectable
5odcG-4xq7A:
undetectable		 5odcA-4xq7A:
19.81
5odcG-4xq7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 VAL A  33
LEU A  34
GLY A  68
THR A  79
VAL A  75
 None
 1.32A 6czmE-4xq7A:
undetectable
6czmF-4xq7A:
undetectable		 6czmE-4xq7A:
21.46
6czmF-4xq7A:
21.46