SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		3 / 3 TRP A 376
ALA A 374
VAL A 444
 None
 0.75A 1bdwA-4xqeA:
undetectable
1bdwB-4xqeA:
undetectable		 1bdwA-4xqeA:
2.55
1bdwB-4xqeA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 8 ASP A 361
ASP A 212
TYR A 323
THR A 228
 AG2  A 505 ( 3.8A)
None
AG2  A 505 (-4.3A)
None
 1.38A 1ceaA-4xqeA:
undetectable
1ceaB-4xqeA:
undetectable		 1ceaA-4xqeA:
13.48
1ceaB-4xqeA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 11 HIS A 322
MET A 253
PRO A 254
LEU A 270
TYR A 368
 None
 1.37A 1mrlA-4xqeA:
undetectable
1mrlB-4xqeA:
undetectable		 1mrlA-4xqeA:
17.05
1mrlB-4xqeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 HIS A 322
MET A 253
PRO A 254
LEU A 270
TYR A 368
 None
 1.27A 1mrlB-4xqeA:
undetectable
1mrlC-4xqeA:
undetectable		 1mrlB-4xqeA:
17.05
1mrlC-4xqeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 PHE A  36
ALA A  81
ILE A  10
ILE A  30
LEU A  79
 None
 1.19A 2bjfA-4xqeA:
undetectable		 2bjfA-4xqeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 5 TRP A 168
ALA A 161
LEU A 431
ALA A 403
 None
NAD  A 501 (-3.5A)
None
None
 1.14A 2jstA-4xqeA:
undetectable
2jstB-4xqeA:
undetectable		 2jstA-4xqeA:
8.51
2jstB-4xqeA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		3 / 3 ARG A 211
ASP A 358
ASN A 329
 None
 0.70A 2zzmA-4xqeA:
3.5		 2zzmA-4xqeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 GLU A 140
LEU A 143
ARG A 147
ALA A 315
TYR A 136
 None
None
None
SO4  A 502 (-3.5A)
None
 1.28A 3k39E-4xqeA:
undetectable		 3k39E-4xqeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 GLU A 140
LEU A 143
ARG A 147
ALA A 315
TYR A 136
 None
None
None
SO4  A 502 (-3.5A)
None
 1.28A 3k39P-4xqeA:
undetectable		 3k39P-4xqeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 11 ALA A 109
LEU A  98
ILE A 419
VAL A  15
LEU A  79
 None
 1.12A 3zosA-4xqeA:
undetectable
3zosB-4xqeA:
undetectable		 3zosA-4xqeA:
22.65
3zosB-4xqeA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 LEU A  74
LEU A  78
CYH A  88
ILE A  17
ILE A  62
 None
None
None
NAD  A 501 ( 4.3A)
None
 1.11A 4a7aB-4xqeA:
1.9		 4a7aB-4xqeA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 6 ALA A 104
ASN A 107
LEU A  79
VAL A  76
 None
 1.04A 4g24A-4xqeA:
undetectable		 4g24A-4xqeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 5 THR A 396
THR A 228
ASP A 212
TYR A 325
 AG2  A 505 ( 3.9A)
None
None
AG2  A 505 ( 4.2A)
 1.47A 4oltB-4xqeA:
undetectable		 4oltB-4xqeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 5 THR A 396
THR A 228
ASP A 212
TYR A 325
 AG2  A 505 ( 3.9A)
None
None
AG2  A 505 ( 4.2A)
 1.48A 4qwpA-4xqeA:
undetectable		 4qwpA-4xqeA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		8 / 8 ARG A 139
ARG A 146
ARG A 191
ASP A 304
PHE A 305
VAL A 420
ASP A 423
ASP A 424
 AG2  A 506 ( 4.2A)
AG2  A 506 (-3.0A)
AG2  A 506 (-4.4A)
AG2  A 506 (-3.0A)
AG2  A 506 (-4.9A)
AG2  A 506 ( 4.5A)
None
AG2  A 506 (-2.4A)
 0.12A 4xqgA-4xqeA:
71.1		 4xqgA-4xqeA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		8 / 8 ARG A 139
ARG A 146
ARG A 191
ASP A 304
PHE A 305
VAL A 420
ASP A 423
ASP A 424
 AG2  A 506 ( 4.2A)
AG2  A 506 (-3.0A)
AG2  A 506 (-4.4A)
AG2  A 506 (-3.0A)
AG2  A 506 (-4.9A)
AG2  A 506 ( 4.5A)
None
AG2  A 506 (-2.4A)
 0.13A 4xqgB-4xqeA:
70.0		 4xqgB-4xqeA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		12 / 12 ASN A 162
PRO A 163
GLU A 210
TRP A 229
GLU A 237
VAL A 294
SER A 296
TYR A 323
TYR A 325
ASP A 361
LEU A 363
THR A 396
 AG2  A 505 ( 2.5A)
NAD  A 501 (-2.9A)
AG2  A 505 (-2.8A)
AG2  A 505 ( 3.3A)
AG2  A 505 (-2.0A)
AG2  A 505 ( 4.6A)
AG2  A 505 (-2.7A)
AG2  A 505 (-4.3A)
AG2  A 505 ( 4.2A)
AG2  A 505 ( 3.8A)
AG2  A 505 ( 4.5A)
AG2  A 505 ( 3.9A)
 0.41A 4xrgA-4xqeA:
71.0		 4xrgA-4xqeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		12 / 12 ALA A 161
ASN A 162
PRO A 163
GLU A 210
TRP A 229
GLU A 237
SER A 296
TYR A 323
TYR A 325
ASP A 361
LEU A 363
THR A 396
 NAD  A 501 (-3.5A)
AG2  A 505 ( 2.5A)
NAD  A 501 (-2.9A)
AG2  A 505 (-2.8A)
AG2  A 505 ( 3.3A)
AG2  A 505 (-2.0A)
AG2  A 505 (-2.7A)
AG2  A 505 (-4.3A)
AG2  A 505 ( 4.2A)
AG2  A 505 ( 3.8A)
AG2  A 505 ( 4.5A)
AG2  A 505 ( 3.9A)
 0.11A 4xrgB-4xqeA:
70.2		 4xrgB-4xqeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 TRP A 229
GLU A 237
TYR A 323
TYR A 325
THR A 228
 AG2  A 505 ( 3.3A)
AG2  A 505 (-2.0A)
AG2  A 505 (-4.3A)
AG2  A 505 ( 4.2A)
None
 1.41A 4xrgB-4xqeA:
70.2		 4xrgB-4xqeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		3 / 5 GLY A 453
GLY A 456
GLU A 460
 None
 0.38A 4z2eA-4xqeA:
undetectable
4z2eD-4xqeA:
undetectable		 4z2eA-4xqeA:
20.52
4z2eD-4xqeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 GLY A  18
GLY A  20
THR A  26
ASP A  45
PRO A  46
 NAD  A 501 ( 3.9A)
NAD  A 501 (-3.3A)
None
NAD  A 501 (-2.7A)
NAD  A 501 (-4.1A)
 1.03A 5bw4A-4xqeA:
undetectable		 5bw4A-4xqeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		3 / 3 GLN A 214
THR A 228
ASP A 212
 None
 0.89A 5k9dA-4xqeA:
undetectable		 5k9dA-4xqeA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 THR A 248
ARG A 139
SER A 299
GLY A 245
ALA A 266
 None
AG2  A 506 ( 4.2A)
None
None
None
 1.19A 5lf7V-4xqeA:
undetectable
5lf7b-4xqeA:
undetectable		 5lf7V-4xqeA:
18.47
5lf7b-4xqeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 THR A 248
ARG A 139
SER A 299
GLY A 245
ALA A 266
 None
AG2  A 506 ( 4.2A)
None
None
None
 1.18A 5lf7H-4xqeA:
undetectable
5lf7N-4xqeA:
undetectable		 5lf7H-4xqeA:
18.47
5lf7N-4xqeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 8 GLU A 243
CYH A 264
TYR A 136
ARG A 318
 None
None
None
SO4  A 502 (-2.9A)
 1.25A 5oajD-4xqeA:
undetectable
5oajE-4xqeA:
undetectable		 5oajD-4xqeA:
19.83
5oajE-4xqeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		4 / 8 ASP A 361
LEU A 363
THR A 396
TYR A 325
 AG2  A 505 ( 3.8A)
AG2  A 505 ( 4.5A)
AG2  A 505 ( 3.9A)
AG2  A 505 ( 4.2A)
 1.23A 5ov9B-4xqeA:
undetectable		 5ov9B-4xqeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 9 GLU A  31
LEU A  27
ARG A  38
GLY A  18
LEU A  91
 None
None
None
NAD  A 501 ( 3.9A)
NAD  A 501 (-4.5A)
 1.42A 5wgqA-4xqeA:
undetectable		 5wgqA-4xqeA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4xqe HOMOSPERMIDINE
SYNTHASE
(Blastochloris
viridis) 		5 / 12 GLY A 397
LEU A 398
GLY A  25
ASN A 227
SER A 401
 None
 1.11A 6mhtA-4xqeA:
2.8		 6mhtA-4xqeA:
21.95