SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.04A 1dfoA-4xqkA:
undetectable		 1dfoA-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.05A 1dfoB-4xqkA:
undetectable		 1dfoB-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.03A 1dfoC-4xqkA:
undetectable		 1dfoC-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.04A 1dfoD-4xqkA:
undetectable		 1dfoD-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.01A 1eqbA-4xqkA:
undetectable		 1eqbA-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.00A 1eqbB-4xqkA:
undetectable		 1eqbB-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.00A 1eqbC-4xqkA:
undetectable		 1eqbC-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 824
VAL A 723
ALA A 650
PHE A 783
ARG A 831
 None
 1.00A 1eqbD-4xqkA:
undetectable		 1eqbD-4xqkA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 PHE A 997
LEU A 777
PHE A 752
PHE A 814
ALA A 770
 None
 1.01A 1fe2A-4xqkA:
undetectable		 1fe2A-4xqkA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 SER A 124
TRP A 546
ARG A 529
LEU A 566
 None
 1.12A 1gahA-4xqkA:
undetectable		 1gahA-4xqkA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 PHE A 904
GLY A1017
THR A1085
PHE A1083
 None
 1.32A 1icuC-4xqkA:
undetectable
1icuD-4xqkA:
undetectable		 1icuC-4xqkA:
8.70
1icuD-4xqkA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 PHE A 904
GLY A1017
THR A1085
PHE A1083
 None
 1.33A 1icvA-4xqkA:
undetectable
1icvB-4xqkA:
undetectable		 1icvA-4xqkA:
8.70
1icvB-4xqkA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 SER A1072
ASP A1073
GLU A1105
GLU A1104
 None
 0.91A 1knyA-4xqkA:
undetectable
1knyB-4xqkA:
undetectable		 1knyA-4xqkA:
10.69
1knyB-4xqkA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 SER A1072
ASP A1073
GLU A1105
GLU A1104
 None
 0.90A 1knyA-4xqkA:
undetectable
1knyB-4xqkA:
undetectable		 1knyA-4xqkA:
10.69
1knyB-4xqkA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 ARG A1283
ARG A1319
ARG A1286
 None
 1.05A 1l7fA-4xqkA:
undetectable		 1l7fA-4xqkA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 ARG A1283
ARG A1319
ARG A1286
 None
 1.07A 1l7hA-4xqkA:
undetectable		 1l7hA-4xqkA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ILE A 559
ALA A 492
ASN A 562
LEU A 575
LEU A 544
 None
 1.19A 1og5B-4xqkA:
1.3		 1og5B-4xqkA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 GLY A 906
ILE A 945
ASP A 981
ASN A1018
PRO A1020
 None
 0.61A 1qaoA-4xqkA:
10.5		 1qaoA-4xqkA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 THR A 210
GLY A 208
ILE A 570
LEU A 544
LEU A 239
 None
 1.14A 1r30A-4xqkA:
undetectable		 1r30A-4xqkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 THR A 210
GLY A 208
ILE A 570
LEU A 544
LEU A 239
 None
 1.14A 1r30B-4xqkA:
undetectable		 1r30B-4xqkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 ALA A1508
ASP A1469
ILE A1468
ILE A1464
 None
 0.75A 1rg9B-4xqkA:
undetectable		 1rg9B-4xqkA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 PHE A 783
LEU A 786
VAL A 828
LEU A 824
LEU A 716
 None
 1.18A 1rlbF-4xqkA:
undetectable		 1rlbF-4xqkA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 TYR A1389
GLY A1214
PHE A1223
SER A1221
 None
 0.99A 2a3cA-4xqkA:
undetectable		 2a3cA-4xqkA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 TYR A1389
GLY A1214
PHE A1223
SER A1221
 None
 0.93A 2a3cB-4xqkA:
undetectable		 2a3cB-4xqkA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 SER A 788
GLU A 826
ASP A 424
 None
 0.73A 2avdB-4xqkA:
10.3		 2avdB-4xqkA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 LEU A1351
ALA A1518
HIS A1417
TYR A1413
 None
 1.36A 2dpzA-4xqkA:
undetectable		 2dpzA-4xqkA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 TYR A1037
ASP A1041
THR A 986
GLU A 987
 None
 1.48A 2dttB-4xqkA:
undetectable
2dttC-4xqkA:
undetectable		 2dttB-4xqkA:
5.55
2dttC-4xqkA:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 GLU A 958
PHE A 936
ILE A 845
ARG A1003
ILE A 955
 None
 1.30A 2e7fA-4xqkA:
undetectable		 2e7fA-4xqkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 GLU A 958
PHE A 936
ILE A 845
ARG A1003
ILE A 955
 None
 1.21A 2e7fB-4xqkA:
undetectable		 2e7fB-4xqkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ASP A1235
ASN A1360
GLY A1233
ASP A1318
GLY A1229
 None
 1.41A 2fqyA-4xqkA:
2.2		 2fqyA-4xqkA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 PRO A1020
PRO A 903
ILE A1015
GLY A1017
 None
 1.03A 2jkjD-4xqkA:
undetectable		 2jkjD-4xqkA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 PRO A1020
PRO A 903
ILE A1015
GLY A1017
 None
 1.02A 2jkjF-4xqkA:
undetectable		 2jkjF-4xqkA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 GLY A1079
ILE A 900
VAL A 881
ILE A 877
VAL A 874
 None
 1.16A 2nnhB-4xqkA:
undetectable		 2nnhB-4xqkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 GLU A 958
PHE A 936
ILE A 845
ARG A1003
ILE A 955
 None
 1.29A 2ogyA-4xqkA:
undetectable		 2ogyA-4xqkA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 GLU A 958
PHE A 936
ILE A 845
ARG A1003
ILE A 955
 None
 1.22A 2ogyB-4xqkA:
undetectable		 2ogyB-4xqkA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 THR A1232
ARG A1234
THR A1277
ASN A1058
 None
 1.18A 2okcA-4xqkA:
22.8		 2okcA-4xqkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ARG A1069
ILE A1143
PHE A1106
GLU A1105
ASP A1073
 None
 1.41A 2qeoA-4xqkA:
undetectable		 2qeoA-4xqkA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 ILE A 666
GLY A 466
ILE A 463
VAL A 614
ILE A 613
 None
 1.14A 2r5qA-4xqkA:
undetectable		 2r5qA-4xqkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 ILE A 666
GLY A 466
ILE A 463
VAL A 614
ILE A 613
 None
 1.15A 2r5qC-4xqkA:
undetectable		 2r5qC-4xqkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 TYR A1426
PHE A1416
TYR A1421
LEU A1339
 None
 1.21A 2w98A-4xqkA:
6.6
2w98B-4xqkA:
6.6		 2w98A-4xqkA:
13.43
2w98B-4xqkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 PHE A1305
HIS A1417
LEU A1565
HIS A1456
TYR A1413
 None
 1.39A 2xkwA-4xqkA:
undetectable		 2xkwA-4xqkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 THR A 869
GLY A 906
THR A 907
THR A 982
ASN A1018
PRO A1020
 None
 0.78A 2y7hB-4xqkA:
19.7		 2y7hB-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 THR A 869
THR A 907
GLY A 908
THR A 982
ASN A1018
PRO A1020
 None
 1.19A 2y7hB-4xqkA:
19.7		 2y7hB-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 THR A 869
GLY A 906
THR A 907
THR A 982
ASN A1018
PRO A1020
 None
 0.78A 2y7hC-4xqkA:
21.1		 2y7hC-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 THR A 869
THR A 907
GLY A 908
THR A 982
ASN A1018
PRO A1020
 None
 1.20A 2y7hC-4xqkA:
21.1		 2y7hC-4xqkA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4xqk LLABIII
(Lactococcus
lactis) 		8 / 12 PRO A1020
PHE A 910
PHE A 904
GLY A 906
THR A 907
THR A 909
GLU A 944
VAL A 946
 None
 1.25A 2zifA-4xqkA:
2.7		 2zifA-4xqkA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 PRO A1020
PHE A 910
PHE A 904
GLY A 906
THR A 907
VAL A 946
 None
 1.31A 2zifB-4xqkA:
2.2		 2zifB-4xqkA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A1397
VAL A1396
SER A1390
VAL A1412
LEU A1210
 None
 1.24A 2zlcA-4xqkA:
undetectable		 2zlcA-4xqkA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 TYR A1037
GLY A 906
ASP A 981
ASN A1018
PRO A1020
 None
 0.72A 3dmfA-4xqkA:
10.2		 3dmfA-4xqkA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 PHE A 997
GLU A 803
SER A 804
VAL A 806
 None
 1.48A 3dqtA-4xqkA:
2.2
3dqtB-4xqkA:
undetectable		 3dqtA-4xqkA:
13.35
3dqtB-4xqkA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 TYR A1267
TYR A1256
ILE A1274
 None
 0.63A 3eteA-4xqkA:
1.4
3eteB-4xqkA:
undetectable		 3eteA-4xqkA:
16.54
3eteB-4xqkA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 GLY A 908
GLN A 842
VAL A 912
ILE A 977
 None
 0.90A 3fi0P-4xqkA:
undetectable		 3fi0P-4xqkA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 11 GLY A 906
GLU A 944
ILE A 945
ASP A 981
ASN A1018
PRO A1020
 None
 0.90A 3grvA-4xqkA:
13.1		 3grvA-4xqkA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 GLY A 906
GLU A 944
ILE A 945
ASP A 981
ASN A1018
PRO A1020
 None
 0.91A 3gryA-4xqkA:
13.1		 3gryA-4xqkA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 4 LYS A 369
SER A 337
LEU A 220
SER A 217
 None
 1.38A 3ik6H-4xqkA:
undetectable		 3ik6H-4xqkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 LYS A 369
SER A 337
LEU A 220
SER A 217
 None
 1.39A 3iluH-4xqkA:
undetectable		 3iluH-4xqkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 PHE A 876
SER A 880
PHE A 910
ASP A 902
ILE A1015
 None
 1.20A 3iv6B-4xqkA:
8.5		 3iv6B-4xqkA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 4 ARG A 596
ASP A 424
GLY A 414
THR A 207
 None
 1.44A 3k4vB-4xqkA:
undetectable		 3k4vB-4xqkA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 10 PRO A1019
GLY A1017
SER A1071
LEU A1145
LYS A1147
 None
 1.32A 3lsfB-4xqkA:
undetectable
3lsfE-4xqkA:
undetectable		 3lsfB-4xqkA:
9.97
3lsfE-4xqkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 GLY A 906
THR A 907
GLU A 944
ASP A 902
 None
 0.89A 3ps9A-4xqkA:
undetectable		 3ps9A-4xqkA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 PHE A 752
ILE A 745
LEU A 773
PHE A 814
 None
 1.03A 3rqwI-4xqkA:
undetectable
3rqwJ-4xqkA:
undetectable		 3rqwI-4xqkA:
11.86
3rqwJ-4xqkA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 PRO A1019
MET A1068
SER A1071
ILE A1081
 None
 0.95A 3sfeB-4xqkA:
undetectable
3sfeC-4xqkA:
2.2		 3sfeB-4xqkA:
9.52
3sfeC-4xqkA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 ALA A 375
PRO A 205
ARG A 599
ARG A 596
 None
 1.09A 3twpB-4xqkA:
undetectable		 3twpB-4xqkA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 4 SER A 279
ASP A 151
ASP A 545
ALA A 537
 None
 1.30A 3uj6A-4xqkA:
undetectable		 3uj6A-4xqkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 LEU A1213
PHE A1223
VAL A1396
LEU A1400
ALA A1408
 None
 1.33A 3unaA-4xqkA:
1.7		 3unaA-4xqkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 LEU A1213
PHE A1223
VAL A1396
LEU A1400
ALA A1408
 None
 1.32A 3unaB-4xqkA:
undetectable		 3unaB-4xqkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 LEU A1213
PHE A1223
VAL A1396
LEU A1400
ALA A1408
 None
 1.32A 3uncA-4xqkA:
1.8		 3uncA-4xqkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 LEU A1213
PHE A1223
VAL A1396
LEU A1400
ALA A1408
 None
 1.32A 3uncB-4xqkA:
undetectable		 3uncB-4xqkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 LEU A1213
VAL A1396
LEU A1400
ALA A1408
 None
 0.82A 3uniB-4xqkA:
undetectable		 3uniB-4xqkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 TYR A1549
TYR A1526
ILE A1493
THR A1306
ILE A1558
 None
 1.28A 3vrjA-4xqkA:
undetectable
3vrjC-4xqkA:
undetectable		 3vrjA-4xqkA:
10.58
3vrjC-4xqkA:
0.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 6 GLY A 906
GLU A 944
ASP A 981
ASP A 902
 None
 0.99A 3vywC-4xqkA:
undetectable		 3vywC-4xqkA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ILE A 437
GLY A 669
VAL A 429
ASN A 628
LEU A 691
 None
 1.22A 4a81A-4xqkA:
undetectable		 4a81A-4xqkA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 LEU A1213
LEU A1369
LEU A1415
LEU A1403
ILE A1392
 None
 1.14A 4dm8A-4xqkA:
undetectable		 4dm8A-4xqkA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 PRO A 903
ASP A 902
ILE A1081
VAL A 881
 None
 1.15A 4hytA-4xqkA:
2.5		 4hytA-4xqkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 5 LEU A1181
TRP A1178
ILE A1162
ASN A1087
 None
 1.47A 4i00A-4xqkA:
undetectable		 4i00A-4xqkA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 ASN A1201
ARG A1203
ALA A1430
GLN A1125
ILE A1090
 None
 1.34A 4j4vA-4xqkA:
1.6		 4j4vA-4xqkA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 ASN A1201
ARG A1203
ALA A1430
GLN A1125
ILE A1090
 None
 1.30A 4j4vD-4xqkA:
undetectable
4j4vE-4xqkA:
1.3		 4j4vD-4xqkA:
9.74
4j4vE-4xqkA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 GLY A 908
ASN A 956
ALA A 838
VAL A 912
ILE A 977
 None
 1.09A 4j4vD-4xqkA:
undetectable
4j4vE-4xqkA:
1.3		 4j4vD-4xqkA:
9.74
4j4vE-4xqkA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 4 ILE A 281
SER A 279
ASP A 151
ASP A 545
 None
 1.48A 4krhB-4xqkA:
2.7		 4krhB-4xqkA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 THR A1306
LEU A1351
TYR A1511
VAL A1560
LEU A1553
 None
 1.43A 4lhmA-4xqkA:
undetectable		 4lhmA-4xqkA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 575
LEU A 547
ARG A 596
LEU A 566
ILE A 491
 None
 0.99A 4x1fA-4xqkA:
undetectable		 4x1fA-4xqkA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 LEU A 575
LEU A 547
ARG A 596
LEU A 566
ILE A 491
 None
 1.03A 4x1gA-4xqkA:
undetectable		 4x1gA-4xqkA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 ASN A 169
TYR A  44
LEU A  40
PHE A  37
 None
 1.14A 4yv5A-4xqkA:
undetectable		 4yv5A-4xqkA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 ASN A1194
LYS A1196
LEU A1102
PHE A1106
 None
 0.75A 4yv5A-4xqkA:
undetectable		 4yv5A-4xqkA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 ALA A1023
ASP A1091
GLY A1139
GLU A1129
 None
 1.00A 5bs8A-4xqkA:
undetectable
5bs8B-4xqkA:
undetectable
5bs8C-4xqkA:
undetectable		 5bs8A-4xqkA:
15.18
5bs8B-4xqkA:
11.00
5bs8C-4xqkA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 THR A 869
ASP A 902
GLU A 944
 None
 0.77A 5fa8A-4xqkA:
11.0		 5fa8A-4xqkA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 TRP A1048
GLU A1105
ASP A1073
 None
 0.95A 5gqbA-4xqkA:
undetectable		 5gqbA-4xqkA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
GLU A 944
 None
 0.58A 5hfjA-4xqkA:
undetectable		 5hfjA-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
 None
 0.66A 5hfjC-4xqkA:
2.8		 5hfjC-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 12 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
GLU A 944
 None
 0.67A 5hfjD-4xqkA:
undetectable		 5hfjD-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ASP A 981
PHE A 904
GLY A 906
THR A 909
GLU A 944
 None
 0.72A 5hfjE-4xqkA:
2.9		 5hfjE-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ASP A 981
PRO A1020
PHE A 904
GLY A 906
GLU A 944
 None
 0.67A 5hfjF-4xqkA:
2.4		 5hfjF-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 ASP A 981
PRO A1020
PHE A 904
GLY A 906
THR A 909
 None
 0.76A 5hfjH-4xqkA:
3.4		 5hfjH-4xqkA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4xqk LLABIII
(Lactococcus
lactis) 		6 / 11 PHE A 904
GLY A 906
GLU A 944
ILE A 945
ASP A 981
PRO A1020
 None
 0.76A 5hjiA-4xqkA:
11.1		 5hjiA-4xqkA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 LEU A1102
ILE A1084
THR A1141
MET A1068
 None
 1.29A 5ljcA-4xqkA:
undetectable		 5ljcA-4xqkA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 THR A1350
TYR A1511
PHE A1305
PRO A1304
 None
 1.16A 5v4vA-4xqkA:
undetectable		 5v4vA-4xqkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 8 THR A1350
TYR A1511
PHE A1305
PRO A1304
 None
 1.18A 5v4vB-4xqkA:
undetectable		 5v4vB-4xqkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 GLY A 367
ASN A 362
ARG A 198
 None
 0.77A 5w7bD-4xqkA:
undetectable		 5w7bD-4xqkA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 THR A 869
ASP A 902
THR A 907
ASN A1018
PRO A1020
 None
 0.59A 5ybbB-4xqkA:
20.9		 5ybbB-4xqkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 GLY A 906
GLY A 908
GLU A 944
THR A 982
 None
 0.57A 5ybbB-4xqkA:
20.9		 5ybbB-4xqkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4xqk LLABIII
(Lactococcus
lactis) 		4 / 7 SER A 804
VAL A 806
PHE A 997
GLU A 803
 None
 1.44A 6av6A-4xqkA:
0.0
6av6B-4xqkA:
undetectable		 6av6A-4xqkA:
4.46
6av6B-4xqkA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 10 SER A1071
LEU A1145
ILE A1084
PRO A1019
GLY A1017
 None
 1.20A 6dm0B-4xqkA:
3.3
6dm0C-4xqkA:
3.4		 6dm0B-4xqkA:
4.49
6dm0C-4xqkA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 9 LEU A1114
ILE A1084
PRO A 870
VAL A 873
ILE A1133
 None
 1.27A 6ef6A-4xqkA:
undetectable		 6ef6A-4xqkA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 TRP A1276
GLU A1028
GLU A1285
 None
 0.92A 6fhwA-4xqkA:
undetectable		 6fhwA-4xqkA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 11 ASN A1018
MET A1068
THR A1138
ILE A1136
VAL A1140
 None
 1.38A 6hcoA-4xqkA:
2.0
6hcoB-4xqkA:
4.4		 6hcoA-4xqkA:
18.19
6hcoB-4xqkA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xqk LLABIII
(Lactococcus
lactis) 		5 / 12 PHE A1305
HIS A1417
LEU A1565
HIS A1456
TYR A1413
 None
 1.41A 6md4A-4xqkA:
undetectable		 6md4A-4xqkA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4xqk LLABIII
(Lactococcus
lactis) 		3 / 3 THR A 869
GLU A 944
ASN A1018
 None
 0.71A 6nj9K-4xqkA:
undetectable		 6nj9K-4xqkA:
14.45