SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 7 THR G 466
ASN G 501
LEU G 828
GLN G 465
 None
 1.04A 1qzrA-4xr7G:
undetectable		 1qzrA-4xr7G:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 11 ARG G 524
ILE G 520
ILE G 519
MET G 529
GLY G 551
 None
 1.21A 2azyA-4xr7G:
undetectable		 2azyA-4xr7G:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 7 ARG L 430
TRP L 429
GLU L 481
ASN L 489
 None
 1.33A 2ejgB-4xr7L:
undetectable		 2ejgB-4xr7L:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		3 / 3 GLN L 408
LYS L 442
VAL L 432
 None
 0.67A 2jfaB-4xr7L:
undetectable		 2jfaB-4xr7L:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 SER G 566
ASP G 826
ASP G 510
 None
 0.68A 2plwA-4xr7G:
undetectable		 2plwA-4xr7G:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 LEU G1004
ASN G 871
ARG G1000
 None
 0.89A 2qhfA-4xr7G:
undetectable		 2qhfA-4xr7G:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 5 VAL L 313
TYR L 322
VAL L 374
ASP L 359
 None
 1.30A 2x45C-4xr7L:
undetectable		 2x45C-4xr7L:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 ARG G 772
GLU G 777
SER G 752
 None
 0.77A 2xctD-4xr7G:
undetectable		 2xctD-4xr7G:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 7 ASP L 318
VAL L 374
ARG L 358
TYR L 291
 None
 1.14A 2yfbA-4xr7L:
undetectable		 2yfbA-4xr7L:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 6 ASP L 318
VAL L 374
ARG L 358
TYR L 291
 None
 1.10A 2yfbB-4xr7L:
3.4		 2yfbB-4xr7L:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 8 TYR G 812
ASN G 813
LYS G 815
PHE L 552
 None
 0.93A 3bjwD-4xr7G:
undetectable		 3bjwD-4xr7G:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		3 / 3 ASP L 359
PHE L 357
SER L 340
 None
 0.99A 3i5uB-4xr7L:
undetectable		 3i5uB-4xr7L:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 851
LEU G 739
GLN G 620
ILE G 699
LEU G 673
 None
 1.30A 3ia4B-4xr7G:
undetectable		 3ia4B-4xr7G:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		5 / 10 PHE L 448
GLY L 424
CYH L 351
ILE L 349
PHE L 375
 None
 1.34A 3ko0L-4xr7L:
undetectable
3ko0N-4xr7L:
undetectable		 3ko0L-4xr7L:
12.53
3ko0N-4xr7L:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		5 / 10 CYH L 351
ILE L 349
PHE L 375
PHE L 448
GLY L 424
 None
 1.37A 3ko0R-4xr7L:
undetectable
3ko0T-4xr7L:
undetectable		 3ko0R-4xr7L:
12.53
3ko0T-4xr7L:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ALA G 775
PHE G 785
ASP G 854
ALA G 855
ASP L 513
 None
 1.25A 3nmuA-4xr7G:
undetectable
3nmuF-4xr7G:
undetectable		 3nmuA-4xr7G:
19.52
3nmuF-4xr7G:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS G 810
ARG G 859
LYS L 550
 None
 1.03A 3okxA-4xr7G:
undetectable		 3okxA-4xr7G:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 PHE G 625
SER G 628
GLN G 629
 None
 0.89A 3smtA-4xr7G:
undetectable		 3smtA-4xr7G:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		5 / 12 LEU L 373
CYH L 446
HIS L 417
ILE L 413
ILE L 349
 None
 1.29A 3sp9A-4xr7L:
undetectable		 3sp9A-4xr7L:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 6 ILE L 349
VAL L 412
LEU L 409
ILE L 423
 None
 0.92A 4asdA-4xr7L:
12.9		 4asdA-4xr7L:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 ARG G 481
ASP G 924
GLN G 926
 None
 0.93A 4azsA-4xr7G:
undetectable		 4azsA-4xr7G:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 4 ILE L 339
SER L 340
ASP L 359
ASP L 376
 None
 1.34A 4krhB-4xr7L:
undetectable		 4krhB-4xr7L:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 5 ASN L 420
LEU L 421
SER L 418
ASN L 350
 None
 1.22A 4n09C-4xr7L:
undetectable		 4n09C-4xr7L:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 6 LEU L 486
ILE L 490
LEU L 402
TYR L 405
 None
 0.98A 4w5nA-4xr7L:
undetectable		 4w5nA-4xr7L:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 6 LEU L 483
GLU L 481
ILE L 441
PRO L 499
 None
 0.96A 4xi3C-4xr7L:
undetectable		 4xi3C-4xr7L:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 THR G 846
ALA G 794
LEU G 805
LEU G 739
PRO G 619
 None
 1.24A 4xi3D-4xr7G:
undetectable		 4xi3D-4xr7G:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		3 / 3 ASP L 359
SER L 315
TYR L 291
 None
 0.91A 5glmA-4xr7L:
undetectable		 5glmA-4xr7L:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 7 ILE G1026
HIS G1023
LEU G 939
ALA G 911
 None
 1.00A 5hrqE-4xr7G:
undetectable
5hrqF-4xr7G:
undetectable
5hrqJ-4xr7G:
undetectable		 5hrqE-4xr7G:
2.95
5hrqF-4xr7G:
4.28
5hrqJ-4xr7G:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 5 LEU L 543
LYS L 538
LEU L 529
TYR L 476
 None
 1.30A 5ki6A-4xr7L:
undetectable		 5ki6A-4xr7L:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3
(Saccharomyces
cerevisiae) 		4 / 9 ILE L 610
PHE L 589
ASP L 597
TRP L 600
 None
 1.02A 5lg3I-4xr7L:
2.6		 5lg3I-4xr7L:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 8 GLY G 506
LEU G 507
ASN G 517
GLN G 521
PHE G 824
 None
 0.59A 5xu8A-4xr7G:
22.4		 5xu8A-4xr7G:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 8 ILE G 722
THR G 666
VAL G 667
GLU G 653
 None
 1.05A 6fbvC-4xr7G:
undetectable		 6fbvC-4xr7G:
21.34