SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Bacillus
cereus) 		4 / 6 ILE A  42
GLN A  39
ILE A  76
ASP A  77
 None
None
GOL  A 207 ( 4.5A)
None
 1.16A 4w5qA-4xrfA:
undetectable		 4w5qA-4xrfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Bacillus
cereus) 		4 / 6 ILE A  42
GLN A  39
ILE A  76
ASP A  77
 None
None
GOL  A 207 ( 4.5A)
None
 1.13A 4w5tA-4xrfA:
undetectable		 4w5tA-4xrfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Bacillus
cereus) 		4 / 6 ILE A  42
GLN A  39
ILE A  76
ASP A  77
 None
None
GOL  A 207 ( 4.5A)
None
 1.20A 4z4cA-4xrfA:
undetectable		 4z4cA-4xrfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Bacillus
cereus) 		4 / 6 ILE A  42
GLN A  39
ILE A  76
ASP A  77
 None
None
GOL  A 207 ( 4.5A)
None
 1.18A 4z4dA-4xrfA:
undetectable		 4z4dA-4xrfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Bacillus
cereus) 		4 / 4 ASP A  77
ILE A  76
ARG A  83
ARG A  74
 None
GOL  A 207 ( 4.5A)
GOL  A 207 (-4.5A)
None
 1.23A 5m67C-4xrfA:
0.6		 5m67C-4xrfA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Bacillus
cereus) 		4 / 6 ILE A  42
GLN A  39
ILE A  76
ASP A  77
 None
None
GOL  A 207 ( 4.5A)
None
 1.15A 6cbdA-4xrfA:
undetectable		 6cbdA-4xrfA:
11.15