SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ILE A 709
ASP A 715
GLY A 714
PHE A 713
VAL A 670
 None
 1.41A 1axwB-4xriA:
undetectable		 1axwB-4xriA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 173
LEU A 127
LEU A 101
ALA A 157
THR A 164
 None
 1.01A 1bzfA-4xriA:
undetectable		 1bzfA-4xriA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 806
ILE A 839
ARG A 860
TRP A 858
 None
 1.21A 1ie9A-4xriA:
undetectable		 1ie9A-4xriA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 SER A 144
ASN A 142
GLY A 147
GLY A 187
GLU A 192
 None
 1.28A 1mehA-4xriA:
undetectable		 1mehA-4xriA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 430
SER A 350
TYR A 354
 None
 0.74A 1x70A-4xriA:
undetectable		 1x70A-4xriA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ALA A 472
SER A 474
ILE A 427
ASP A 431
 None
 0.84A 1yc2A-4xriA:
undetectable		 1yc2A-4xriA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ALA A 472
SER A 474
ILE A 427
ASP A 431
 None
 0.85A 1yc5A-4xriA:
undetectable		 1yc5A-4xriA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 246
LEU A 248
ILE A 251
LEU A 205
ILE A 202
 None
 1.01A 2f8dA-4xriA:
undetectable		 2f8dA-4xriA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 GLY A 246
LEU A 248
ILE A 251
LEU A 205
ILE A 202
 None
 0.98A 2f8dB-4xriA:
undetectable		 2f8dB-4xriA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 MET A 259
ARG A 250
LEU A 209
VAL A 229
 None
 1.34A 2hrcA-4xriA:
undetectable		 2hrcA-4xriA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 SER A 172
LEU A 173
ASP A 166
ASP A 168
 None
 1.19A 2j2pE-4xriA:
undetectable
2j2pF-4xriA:
undetectable		 2j2pE-4xriA:
12.50
2j2pF-4xriA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 592
THR A 588
LEU A 631
MET A 635
GLY A 600
 None
 1.04A 2ouzA-4xriA:
undetectable		 2ouzA-4xriA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 738
LEU A 696
PHE A 713
ILE A 667
TYR A 754
 None
 0.98A 2w3bA-4xriA:
undetectable		 2w3bA-4xriA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 738
LEU A 696
PHE A 713
ILE A 667
TYR A 754
 None
 1.01A 2w3bB-4xriA:
undetectable		 2w3bB-4xriA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 738
LEU A 696
PHE A 713
ILE A 667
TYR A 754
 None
 1.03A 2w3mA-4xriA:
undetectable		 2w3mA-4xriA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ILE A 596
ALA A 630
LEU A 607
ILE A 603
ILE A 551
 None
 1.04A 2w9sA-4xriA:
undetectable		 2w9sA-4xriA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ILE A 596
ALA A 630
LEU A 607
ILE A 603
ILE A 551
 None
 1.06A 2w9sB-4xriA:
undetectable		 2w9sB-4xriA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASN A 502
SER A 504
PHE A 501
ASN A 495
 None
 1.17A 2wekA-4xriA:
undetectable		 2wekA-4xriA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASN A 502
SER A 504
PHE A 501
ASN A 495
 None
 1.16A 2wekB-4xriA:
undetectable		 2wekB-4xriA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 VAL A 813
GLY A 771
GLY A 768
ILE A 789
ALA A 820
 None
 0.90A 2z0yA-4xriA:
undetectable		 2z0yA-4xriA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 LEU A 806
ILE A 839
ARG A 860
TRP A 858
 None
 1.21A 2zlcA-4xriA:
undetectable		 2zlcA-4xriA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
 None
 1.12A 3a51A-4xriA:
undetectable		 3a51A-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
 None
 1.08A 3a51C-4xriA:
undetectable		 3a51C-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
 None
 1.09A 3a51D-4xriA:
3.0		 3a51D-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
 None
 1.10A 3a51E-4xriA:
undetectable		 3a51E-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 VAL A 140
GLN A 150
GLY A 112
LEU A  48
 None
None
GOL  A 917 ( 3.9A)
None
 0.97A 3bjwE-4xriA:
undetectable		 3bjwE-4xriA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LEU A  21
GLU A  12
ILE A   9
 None
 0.58A 3czhA-4xriA:
undetectable		 3czhA-4xriA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TYR A  40
GLY A  62
THR A  43
GLU A  54
 None
None
None
SO4  A 902 (-4.5A)
 1.02A 3fpjA-4xriA:
undetectable		 3fpjA-4xriA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 MET A 763
VAL A 813
ILE A 796
ILE A 814
 None
 0.78A 3gcsA-4xriA:
undetectable		 3gcsA-4xriA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 113
THR A 156
GLU A 163
THR A 164
 None
GOL  A 917 (-3.6A)
None
None
 1.45A 3glqB-4xriA:
undetectable		 3glqB-4xriA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ALA A 856
ARG A 860
LYS A 864
 None
 0.74A 3kp3B-4xriA:
undetectable		 3kp3B-4xriA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ALA A 856
ARG A 860
LYS A 864
 None
 0.55A 3kp5B-4xriA:
undetectable		 3kp5B-4xriA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 113
THR A 156
GLU A 163
THR A 164
 None
GOL  A 917 (-3.6A)
None
None
 1.41A 3n58A-4xriA:
undetectable		 3n58A-4xriA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 1.05A 3n8yA-4xriA:
undetectable		 3n8yA-4xriA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ALA A 645
LEU A 611
ILE A 628
ALA A 627
VAL A 620
 GOL  A 915 ( 4.5A)
GOL  A 911 ( 4.1A)
None
None
None
 1.33A 3r9cA-4xriA:
2.8		 3r9cA-4xriA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 VAL A 528
PHE A 462
LEU A 497
ILE A 482
 None
 0.85A 3rfmA-4xriA:
undetectable		 3rfmA-4xriA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ALA A 391
VAL A 429
ALA A 436
PRO A 417
LEU A 380
 None
 1.02A 3sm2B-4xriA:
undetectable		 3sm2B-4xriA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 173
ILE A 161
CYH A 162
ILE A 119
ARG A 141
 None
 1.32A 3uj7A-4xriA:
undetectable		 3uj7A-4xriA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 620
ILE A 596
ILE A 603
VAL A 606
LEU A 607
 None
 0.94A 3w67B-4xriA:
undetectable		 3w67B-4xriA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 620
ILE A 596
ILE A 603
VAL A 606
LEU A 607
 None
 0.84A 3w68C-4xriA:
undetectable		 3w68C-4xriA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 620
ILE A 596
ILE A 603
VAL A 606
LEU A 607
 None
 0.88A 3w68D-4xriA:
undetectable		 3w68D-4xriA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ALA A 116
ALA A 100
LEU A 104
THR A 103
 None
 1.00A 4dtzA-4xriA:
undetectable		 4dtzA-4xriA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LYS A  83
LEU A  80
ALA A  82
 None
 0.72A 4ikiA-4xriA:
undetectable		 4ikiA-4xriA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 738
LEU A 696
PHE A 713
ILE A 667
TYR A 754
 None
 1.04A 4kebB-4xriA:
undetectable		 4kebB-4xriA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 738
LEU A 696
PHE A 713
ILE A 667
TYR A 754
 None
 1.02A 4kfjB-4xriA:
undetectable		 4kfjB-4xriA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A  63
ALA A 114
ALA A  47
LEU A  29
ILE A   7
 None
 1.10A 4lnxA-4xriA:
undetectable		 4lnxA-4xriA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 738
LEU A 696
PHE A 713
ILE A 667
TYR A 754
 None
 1.03A 4m6kA-4xriA:
undetectable		 4m6kA-4xriA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 1.02A 4rrwA-4xriA:
undetectable		 4rrwA-4xriA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 0.99A 4rrwB-4xriA:
undetectable		 4rrwB-4xriA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 1.01A 4rrwC-4xriA:
undetectable		 4rrwC-4xriA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 1.02A 4rrzA-4xriA:
undetectable		 4rrzA-4xriA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 0.99A 4rrzB-4xriA:
undetectable		 4rrzB-4xriA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 1.01A 4rrzC-4xriA:
undetectable		 4rrzC-4xriA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ASN A 195
ILE A 240
THR A 203
GLY A 243
GLU A 196
 None
 1.37A 4xt7A-4xriA:
undetectable		 4xt7A-4xriA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 140
LEU A 139
ILE A 158
GLY A 159
LEU A 169
 None
 0.90A 4y8wA-4xriA:
undetectable		 4y8wA-4xriA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 140
LEU A 139
ILE A 158
GLY A 159
LEU A 169
 None
 0.86A 4y8wB-4xriA:
undetectable		 4y8wB-4xriA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 SER A 788
LEU A 758
LEU A 710
LEU A 735
LEU A 696
 None
 1.06A 4yiaA-4xriA:
undetectable		 4yiaA-4xriA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLY A 396
ARG A 439
GLY A 438
GLU A 442
 None
 0.97A 4z2eB-4xriA:
undetectable
4z2eC-4xriA:
undetectable		 4z2eB-4xriA:
19.42
4z2eC-4xriA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ALA A 143
LEU A 104
LEU A 155
SER A 208
ALA A 204
 None
 1.06A 4zbrA-4xriA:
undetectable		 4zbrA-4xriA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLU A 301
ALA A 363
GLU A 297
ASN A 318
 None
 1.48A 5dwkC-4xriA:
2.8		 5dwkC-4xriA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 TYR A 821
PHE A 830
GLY A 815
LEU A 782
 None
 0.80A 5hs1A-4xriA:
undetectable		 5hs1A-4xriA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 544
LEU A 547
SER A 548
VAL A 584
ALA A 587
 None
 1.16A 5ikrA-4xriA:
0.6		 5ikrA-4xriA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ALA A 232
ALA A 244
ILE A 202
LEU A 205
 None
 0.80A 5jncD-4xriA:
undetectable		 5jncD-4xriA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 673
LEU A 677
SER A 681
ALA A 647
LEU A 650
 None
 0.99A 5jvzB-4xriA:
undetectable		 5jvzB-4xriA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ILE A 814
ALA A 818
LEU A 817
ILE A 770
 None
 0.86A 5mvmB-4xriA:
3.3
5mvmC-4xriA:
3.3		 5mvmB-4xriA:
5.57
5mvmC-4xriA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 321
ALA A 320
PHE A 316
GLU A 301
 None
 1.41A 5odqA-4xriA:
undetectable		 5odqA-4xriA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ALA A  68
LYS A  83
PHE A  37
ILE A 125
 None
 0.94A 5of1B-4xriA:
undetectable		 5of1B-4xriA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ILE A 720
ALA A 772
LEU A 728
ILE A 716
 None
 0.77A 5uihA-4xriA:
undetectable		 5uihA-4xriA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 692
LEU A 654
SER A 671
ALA A 666
 None
 1.14A 5uunA-4xriA:
4.5		 5uunA-4xriA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 250
PHE A 245
ILE A 202
THR A 203
 None
 0.86A 5vceA-4xriA:
undetectable		 5vceA-4xriA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 173
ILE A 161
GLY A 159
LEU A 104
MET A 136
 None
 0.99A 5ycnA-4xriA:
undetectable		 5ycnA-4xriA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 229
THR A 233
LEU A 209
GLY A 246
VAL A 184
 None
 1.13A 6a94B-4xriA:
3.0		 6a94B-4xriA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4xri PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 MET A 604
ALA A 645
PHE A 646
ALA A 647
LEU A 677
 None
GOL  A 915 ( 4.5A)
None
None
None
 1.40A 6ay4A-4xriA:
undetectable		 6ay4A-4xriA:
18.39