SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		3 / 3 ALA A  42
VAL A  40
TRP A  58
 None
 0.90A 1bdwA-4xrtA:
undetectable
1bdwB-4xrtA:
undetectable		 1bdwA-4xrtA:
3.44
1bdwB-4xrtA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		5 / 11 TYR A 283
LEU A 271
THR A 206
PRO A 207
LEU A 237
 None
 1.22A 2ft9A-4xrtA:
2.7		 2ft9A-4xrtA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		5 / 11 LEU A  29
TRP A  72
HIS A  56
ILE A  81
LEU A 134
 None
 1.25A 4yvpA-4xrtA:
undetectable		 4yvpA-4xrtA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		5 / 12 LEU A  29
TRP A  72
HIS A  56
ILE A  81
LEU A 134
 None
 1.24A 4yvpB-4xrtA:
undetectable		 4yvpB-4xrtA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		3 / 3 ALA A 280
TYR A 283
PRO A 234
 None
 0.47A 4zdyA-4xrtA:
undetectable		 4zdyA-4xrtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		4 / 8 HIS A 240
LEU A 233
MET A 202
THR A 204
 None
 0.93A 5hs6A-4xrtA:
undetectable		 5hs6A-4xrtA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		5 / 11 LEU A 126
ALA A 127
GLU A 130
ARG A  66
LEU A   9
 None
 1.47A 5hyrB-4xrtA:
undetectable		 5hyrB-4xrtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		4 / 7 LEU A  21
ASP A  24
ALA A  27
LEU A  29
 None
 1.04A 5nwvA-4xrtA:
undetectable		 5nwvA-4xrtA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		5 / 10 LEU A  21
VAL A  26
LEU A  25
THR A 139
ALA A 142
 None
 1.05A 5o96G-4xrtA:
undetectable
5o96H-4xrtA:
undetectable		 5o96G-4xrtA:
21.94
5o96H-4xrtA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4xrt STFQ
AROMATASE/CYCLASE
(Streptomyces
steffisburgensis) 		5 / 10 LEU A 126
ALA A 127
GLU A 130
ARG A  66
LEU A   9
 None
 1.46A 6cbzB-4xrtA:
undetectable		 6cbzB-4xrtA:
13.78