SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4xru HEN1
(Capnocytophaga
gingivalis) 		3 / 3 LEU C  15
SER C 160
ASN C 166
 None
 0.70A 1bx4A-4xruC:
3.5		 1bx4A-4xruC:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xru HEN1
RNL
(Capnocytophaga
gingivalis) 		5 / 10 ALA C  28
LEU B 155
SER B 154
PHE B 201
ILE B 198
 None
 1.24A 1g5yC-4xruC:
undetectable		 1g5yC-4xruC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		4 / 8 SER B 291
ASN B 289
ASP B 286
GLU B  37
 None
GOL  B 503 ( 4.4A)
None
GOL  B 503 ( 4.6A)
 1.21A 1mxgA-4xruB:
undetectable		 1mxgA-4xruB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 11 GLY C 271
VAL C 339
GLU C 338
ASP C 269
ILE C 270
 SAH  C 501 (-3.4A)
SAH  C 501 ( 3.8A)
None
None
None
 1.11A 1pk9C-4xruC:
undetectable		 1pk9C-4xruC:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		3 / 3 GLN B 163
ILE B 162
TYR B 168
 None
 0.74A 1vifA-4xruB:
undetectable		 1vifA-4xruB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 7 VAL C 173
THR C 174
THR C 178
ARG C 216
 None
 0.62A 2kotA-4xruC:
undetectable		 2kotA-4xruC:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 7 TYR C 122
SER C  72
CYH C  71
GLN C  64
 None
None
None
MG  C 502 (-4.3A)
 1.11A 2xz5A-4xruC:
undetectable
2xz5B-4xruC:
undetectable		 2xz5A-4xruC:
20.89
2xz5B-4xruC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 8 TYR C 122
SER C  72
CYH C  71
GLN C  64
 None
None
None
MG  C 502 (-4.3A)
 1.13A 2xz5B-4xruC:
undetectable
2xz5E-4xruC:
undetectable		 2xz5B-4xruC:
20.89
2xz5E-4xruC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4xru PNKP1
(Capnocytophaga
gingivalis) 		4 / 5 ILE A 276
MET A 295
LEU A 285
LEU A 302
 None
 1.18A 2zb7A-4xruA:
4.1		 2zb7A-4xruA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 6 ILE C 171
ARG C 155
THR C 145
LEU C 152
 None
 1.01A 3ag1N-4xruC:
undetectable
3ag1W-4xruC:
undetectable		 3ag1N-4xruC:
20.49
3ag1W-4xruC:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 5 ILE C 144
THR C 174
PHE C 170
PHE C 139
 None
 1.31A 3em0A-4xruC:
undetectable		 3em0A-4xruC:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 5 THR C 174
PHE C 170
PHE C 139
TYR C 138
 None
 1.29A 3em0A-4xruC:
undetectable		 3em0A-4xruC:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 8 ILE C 202
PRO C 203
HIS C 143
GLY C 158
 None
 0.75A 3em0B-4xruC:
undetectable		 3em0B-4xruC:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4xru HEN1
RNL
(Capnocytophaga
gingivalis) 		4 / 8 SER B 142
ASP C  66
LEU C  74
PRO C  73
 None
 0.99A 3jq7B-4xruB:
undetectable		 3jq7B-4xruB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4xru RNL
(Capnocytophaga
gingivalis) 		4 / 7 TYR B 324
GLU B 334
LEU B 320
ASN B 317
 None
None
None
GOL  B 503 (-3.7A)
 1.17A 3k8mB-4xruB:
undetectable		 3k8mB-4xruB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4xru HEN1
RNL
(Capnocytophaga
gingivalis) 		5 / 10 TYR B 156
LEU B 150
VAL C  49
ILE C  37
ILE B 198
 None
 1.15A 3kz7A-4xruB:
undetectable		 3kz7A-4xruB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		7 / 12 ILE B  26
GLU B  59
GLU B 120
PHE B 234
VAL B 297
LYS B 299
LYS B 313
 ATP  B 501 (-4.0A)
ATP  B 501 (-3.8A)
ATP  B 501 ( 2.9A)
ATP  B 501 (-3.4A)
None
ATP  B 501 (-3.5A)
ATP  B 501 (-2.4A)
 0.92A 3qwuA-4xruB:
10.4		 3qwuA-4xruB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		7 / 12 ILE B  26
GLU B  59
LYS B  61
GLU B 120
PHE B 234
VAL B 297
LYS B 299
 ATP  B 501 (-4.0A)
ATP  B 501 (-3.8A)
ATP  B 501 (-2.3A)
ATP  B 501 ( 2.9A)
ATP  B 501 (-3.4A)
None
ATP  B 501 (-3.5A)
 1.12A 3qwuA-4xruB:
10.4		 3qwuA-4xruB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		7 / 11 ILE B  26
GLU B  59
LYS B  61
GLU B 120
PHE B 234
VAL B 297
LYS B 299
 ATP  B 501 (-4.0A)
ATP  B 501 (-3.8A)
ATP  B 501 (-2.3A)
ATP  B 501 ( 2.9A)
ATP  B 501 (-3.4A)
None
ATP  B 501 (-3.5A)
 0.96A 3qwuB-4xruB:
10.7		 3qwuB-4xruB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 6 PHE C  67
ASN C 151
ALA C 123
THR C 175
 None
 0.97A 3t3sB-4xruC:
undetectable		 3t3sB-4xruC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 6 SER C 169
VAL C 205
THR C 175
THR C 178
 None
 1.00A 3tneA-4xruC:
undetectable		 3tneA-4xruC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 11 GLY C 271
VAL C 339
GLU C 338
ASP C 269
ILE C 270
 SAH  C 501 (-3.4A)
SAH  C 501 ( 3.8A)
None
None
None
 1.18A 3uawA-4xruC:
undetectable		 3uawA-4xruC:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4xru PNKP1
(Capnocytophaga
gingivalis) 		4 / 7 ASP A 288
GLY A 230
THR A 187
LYS A 268
 MG  A 401 (-2.2A)
None
None
None
 1.16A 3vnsA-4xruA:
3.0		 3vnsA-4xruA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4xru PNKP1
(Capnocytophaga
gingivalis) 		3 / 3 ASN A  81
TRP A  38
ASP A 106
 None
 1.23A 4a7tA-4xruA:
undetectable
4a7tF-4xruA:
undetectable		 4a7tA-4xruA:
19.68
4a7tF-4xruA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 12 TYR C 181
THR C 178
ILE C  76
LYS C   1
ILE C 198
 None
 1.35A 4eb6B-4xruC:
undetectable
4eb6C-4xruC:
undetectable		 4eb6B-4xruC:
20.60
4eb6C-4xruC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4xru RNL
(Capnocytophaga
gingivalis) 		3 / 3 TYR B 195
ARG B 193
HIS B 190
 None
 0.96A 4fubA-4xruB:
undetectable		 4fubA-4xruB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 12 LEU C 199
GLY C 419
ASP C 420
PHE C 244
THR C 249
 None
 1.44A 4mubA-4xruC:
undetectable		 4mubA-4xruC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4xru PNKP1
(Capnocytophaga
gingivalis) 		3 / 3 ASP A 288
ASP A 287
ASN A 265
 MG  A 401 (-2.2A)
MG  A 401 ( 4.8A)
None
 0.80A 4q5mA-4xruA:
undetectable		 4q5mA-4xruA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		5 / 11 GLY B  64
ASP B 260
ILE B 258
ASN B 259
SER B 254
 MG  B 505 (-4.7A)
None
None
None
None
 1.05A 4rtrA-4xruB:
undetectable		 4rtrA-4xruB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4xru RNL
(Capnocytophaga
gingivalis) 		5 / 12 GLY B  64
ASP B 260
ILE B 258
ASN B 259
SER B 254
 MG  B 505 (-4.7A)
None
None
None
None
 1.08A 4rtsA-4xruB:
undetectable		 4rtsA-4xruB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4xru PNKP1
(Capnocytophaga
gingivalis) 		5 / 9 ARG A 236
LEU A 243
SER A 229
LEU A 227
ILE A 226
 None
 1.31A 4ubsA-4xruA:
undetectable		 4ubsA-4xruA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4xru PNKP1
(Capnocytophaga
gingivalis) 		5 / 12 GLY A 186
LEU A 184
ASN A 308
ARG A 297
CYH A 304
 MG  A 401 ( 4.7A)
None
None
None
None
 1.22A 4x61A-4xruA:
3.2		 4x61A-4xruA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 6 ILE C 227
GLN C 223
ILE C 187
ASP C 188
 None
 1.16A 4z4dA-4xruC:
undetectable		 4z4dA-4xruC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 6 LEU C  15
SER C 160
PRO C 113
GLU C 157
 None
 1.29A 5b8iA-4xruC:
undetectable		 5b8iA-4xruC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4xru RNL
(Capnocytophaga
gingivalis) 		4 / 8 ILE B 126
SER B 119
GLU B 120
CYH B  67
 None
None
ATP  B 501 ( 2.9A)
None
 0.94A 5dqyA-4xruB:
undetectable		 5dqyA-4xruB:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4xru PNKP1
(Capnocytophaga
gingivalis) 		5 / 12 GLY A 186
LEU A 184
ASN A 308
ARG A 297
CYH A 304
 MG  A 401 ( 4.7A)
None
None
None
None
 1.30A 5emlA-4xruA:
2.1		 5emlA-4xruA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 9 ILE C 340
THR C 295
LEU C 351
GLN C 429
LEU C 268
 None
SAH  C 501 ( 4.4A)
SAH  C 501 (-4.3A)
PO4  C 503 ( 4.8A)
None
 1.23A 5fhzB-4xruC:
3.0		 5fhzB-4xruC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 9 ASP C 188
HIS C 176
ILE C 187
SER C  72
TYR C  57
 None
 1.40A 5ha9B-4xruC:
undetectable		 5ha9B-4xruC:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 12 MET C 165
ILE C 116
MET C   1
VAL C  48
ILE C   5
 None
 1.28A 5mlmA-4xruC:
6.1		 5mlmA-4xruC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4xru RNL
(Capnocytophaga
gingivalis) 		4 / 5 ILE B  69
SER B 119
ALA B  99
LEU B  75
 None
 0.96A 6dwnA-4xruB:
undetectable		 6dwnA-4xruB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 10 PHE C  84
LEU C  87
ILE C  79
ILE C   5
ILE C 116
 None
 1.00A 6ebpD-4xruC:
undetectable		 6ebpD-4xruC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 11 PHE C  84
LEU C  87
ILE C  79
ILE C   5
ILE C 116
 None
 1.02A 6ebzA-4xruC:
undetectable		 6ebzA-4xruC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 11 PHE C  84
LEU C  87
ILE C  79
ILE C   5
ILE C 116
 None
 1.03A 6ebzB-4xruC:
undetectable		 6ebzB-4xruC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 11 PHE C  84
LEU C  87
ILE C  79
ILE C   5
ILE C 116
 None
 1.02A 6ebzC-4xruC:
undetectable		 6ebzC-4xruC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 11 PHE C  84
LEU C  87
ILE C  79
ILE C   5
ILE C 116
 None
 1.00A 6ebzD-4xruC:
undetectable		 6ebzD-4xruC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4xru HEN1
(Capnocytophaga
gingivalis) 		5 / 12 ASN C 179
ILE C  76
THR C 145
ILE C 147
PHE C 133
 None
 1.39A 6j20A-4xruC:
undetectable		 6j20A-4xruC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xru RNL
HEN1
(Capnocytophaga
gingivalis;
Capnocytophaga
gingivalis) 		5 / 12 GLY C  34
HIS B 143
TYR B 209
LEU B 150
ILE C  37
 None
 1.18A 6md4A-4xruC:
undetectable		 6md4A-4xruC:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 8 TRP C 323
HIS C 342
ASP C 269
GLU C 274
 None
SAH  C 501 (-3.6A)
None
None
 1.17A 6mn4A-4xruC:
undetectable		 6mn4A-4xruC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4xru HEN1
(Capnocytophaga
gingivalis) 		4 / 7 TRP C 323
HIS C 342
ASP C 269
GLU C 274
 None
SAH  C 501 (-3.6A)
None
None
 1.23A 6mn4F-4xruC:
undetectable		 6mn4F-4xruC:
18.65