SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4xrw BEXL
(Amycolatopsis
orientalis) 		5 / 12 ALA A 113
PRO A 118
GLY A 119
GLY A 120
LYS A   1
 None
 0.98A 1eizA-4xrwA:
undetectable		 1eizA-4xrwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4xrw BEXL
(Amycolatopsis
orientalis) 		5 / 12 ALA A 113
PRO A 118
GLY A 119
GLY A 120
LYS A   1
 None
 0.99A 1ej0A-4xrwA:
undetectable		 1ej0A-4xrwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4xrw BEXL
(Amycolatopsis
orientalis) 		5 / 10 VAL A 217
THR A 231
GLU A 215
ALA A  55
THR A  54
 None
 1.23A 1r55A-4xrwA:
undetectable		 1r55A-4xrwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xrw BEXL
(Amycolatopsis
orientalis) 		4 / 6 ALA A 175
TYR A 228
ILE A 226
LEU A 200
 None
 1.05A 1xvaA-4xrwA:
undetectable
1xvaB-4xrwA:
undetectable		 1xvaA-4xrwA:
23.74
1xvaB-4xrwA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4xrw BEXL
(Amycolatopsis
orientalis) 		4 / 4 GLU A 306
GLY A 253
THR A 254
GLU A 249
 None
 1.07A 3e9xA-4xrwA:
undetectable		 3e9xA-4xrwA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4xrw BEXL
(Amycolatopsis
orientalis) 		4 / 7 TRP A 244
TYR A 228
HIS A 240
PHE A 155
 None
 1.37A 3s3gA-4xrwA:
undetectable		 3s3gA-4xrwA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4xrw BEXL
(Amycolatopsis
orientalis) 		3 / 3 VAL A  98
SER A  99
THR A 102
 None
 0.31A 4luhA-4xrwA:
undetectable		 4luhA-4xrwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4xrw BEXL
(Amycolatopsis
orientalis) 		5 / 12 LEU A 107
HIS A   6
SER A  82
ILE A 124
ASP A 125
 None
 1.36A 6bxnA-4xrwA:
undetectable		 6bxnA-4xrwA:
22.14