SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 ILE A  51
LEU A 100
ILE A  68
LEU A  84
ILE A  47
 None
 1.01A 1ra2A-4xsqA:
undetectable		 1ra2A-4xsqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 ILE A  51
LEU A 100
ILE A  68
LEU A  84
ILE A  47
 None
 0.96A 1ra8A-4xsqA:
undetectable		 1ra8A-4xsqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 ILE A  51
LEU A 100
ILE A  68
LEU A  84
ILE A  47
 None
 0.97A 1rb2A-4xsqA:
undetectable		 1rb2A-4xsqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 ILE A  51
LEU A 100
ILE A  68
LEU A  84
ILE A  47
 None
 0.98A 1rd7A-4xsqA:
undetectable		 1rd7A-4xsqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 ILE A  51
LEU A 100
ILE A  68
LEU A  84
ILE A  47
 None
 1.03A 1rd7B-4xsqA:
undetectable		 1rd7B-4xsqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 11 ILE A  89
SER A  93
SER A 117
LEU A  84
LEU A  97
 None
 1.45A 3h6tA-4xsqA:
undetectable
3h6tC-4xsqA:
undetectable		 3h6tA-4xsqA:
18.28
3h6tC-4xsqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 10 PHE A  73
LEU A 139
VAL A 116
PHE A 121
VAL A 137
 None
 1.36A 3u9fE-4xsqA:
undetectable		 3u9fE-4xsqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 PHE A  73
LEU A 139
VAL A 116
PHE A 121
VAL A 137
 None
 1.40A 3u9fJ-4xsqA:
undetectable
3u9fK-4xsqA:
undetectable		 3u9fJ-4xsqA:
22.32
3u9fK-4xsqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 10 PHE A  73
LEU A 139
VAL A 116
PHE A 121
VAL A 137
 None
 1.47A 3u9fR-4xsqA:
undetectable		 3u9fR-4xsqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4xsq VARIABLE LYMPHOCYTE
RECEPTOR-LIKE
PROTEIN BF66946
(Branchiostoma
floridae) 		5 / 12 ILE A  51
LEU A 100
ILE A  68
LEU A  84
ILE A  47
 None
 0.98A 4ej1A-4xsqA:
undetectable		 4ej1A-4xsqA:
23.47