SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xsr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU B 222
SER B 330
VAL B 261
LEU B 248
HIS B 205
 None
 1.39A 1ie9A-4xsrB:
undetectable		 1ie9A-4xsrB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU B  34
LEU B   6
ALA B 112
ALA B 108
LEU B  80
 None
 1.39A 1iiuA-4xsrB:
undetectable		 1iiuA-4xsrB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU B  34
LEU B   6
ALA B 112
ALA B 108
LEU B  80
 None
 1.38A 1kt5A-4xsrB:
undetectable		 1kt5A-4xsrB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 GLY B 164
VAL B 138
LEU B 124
LEU B 120
ALA B 141
 None
 1.41A 1pbcA-4xsrB:
3.1		 1pbcA-4xsrB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 200
VAL B 229
GLY B 204
SER B 207
HIS B 205
 None
None
None
UPG  B 403 ( 4.7A)
None
 1.21A 2cl5A-4xsrB:
4.2		 2cl5A-4xsrB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 THR B  87
ALA B  96
PHE B  35
LEU B 116
 None
 1.01A 2hzqA-4xsrB:
undetectable		 2hzqA-4xsrB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLN B  99
ALA B 101
GLY B  13
LEU B  17
ASP B   7
 None
None
UPG  B 403 ( 4.0A)
UPG  B 403 (-4.6A)
None
 1.14A 2nv4A-4xsrB:
undetectable		 2nv4A-4xsrB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 THR B 347
ILE B 337
LEU B 279
ALA B 281
THR B 283
 None
 1.21A 3a50A-4xsrB:
undetectable		 3a50A-4xsrB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 CYH B 225
ALA B 221
LEU B 218
ALA B 231
VAL B 229
 None
 1.26A 3e22D-4xsrB:
5.4		 3e22D-4xsrB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE B  94
SER B 146
LEU B 116
SER B 109
ARG B 165
 None
 1.16A 3gyqA-4xsrB:
4.4
3gyqB-4xsrB:
3.3		 3gyqA-4xsrB:
23.38
3gyqB-4xsrB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 PHE B 362
GLY B 175
ALA B 312
GLY B 311
MET B 298
 None
 1.24A 3v3oA-4xsrB:
3.7		 3v3oA-4xsrB:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 PHE B 362
GLY B 175
ALA B 312
GLY B 311
MET B 298
 None
 1.20A 3v3oB-4xsrB:
2.4		 3v3oB-4xsrB:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ARG B 208
GLY B  13
ASN B  97
MET B 274
 UPG  B 403 (-3.6A)
UPG  B 403 ( 4.0A)
None
None
 1.31A 4g0vB-4xsrB:
undetectable		 4g0vB-4xsrB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ALA B 150
ASN B 151
LEU B 120
GLU B 288
 None
UPG  B 403 (-3.9A)
None
UPG  B 403 (-3.5A)
 0.87A 4g24A-4xsrB:
undetectable		 4g24A-4xsrB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA B  88
ILE B  94
LEU B 140
ILE B 107
THR B  87
 None
None
None
EPE  B 401 ( 4.7A)
None
 1.01A 4km0B-4xsrB:
undetectable		 4km0B-4xsrB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 VAL B 304
ALA B 351
PHE B 323
THR B 347
 None
 1.39A 4z4fA-4xsrB:
2.7		 4z4fA-4xsrB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 VAL B 304
ALA B 351
PHE B 323
THR B 347
 None
 1.39A 4z4hA-4xsrB:
2.7		 4z4hA-4xsrB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 PRO B 327
HIS B 205
ILE B 294
VAL B 316
 None
 0.98A 4zj8A-4xsrB:
9.9		 4zj8A-4xsrB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 LEU B   6
GLY B 105
ALA B 106
SER B 109
 None
 0.66A 5f1aA-4xsrB:
undetectable		 5f1aA-4xsrB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 200
VAL B 229
GLY B 204
SER B 207
HIS B 205
 None
None
None
UPG  B 403 ( 4.7A)
None
 1.25A 5lsaA-4xsrB:
4.4		 5lsaA-4xsrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU B 273
ALA B 275
ILE B 232
GLY B 204
LEU B 191
 None
 1.08A 5nfjB-4xsrB:
3.6		 5nfjB-4xsrB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU B 273
ALA B 275
ILE B 232
GLY B 204
LEU B 191
 None
 1.08A 5nfjC-4xsrB:
3.5		 5nfjC-4xsrB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		7 / 10 GLY B  14
HIS B 121
ASN B 174
LYS B 213
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.9A)
UPG  B 403 (-3.2A)
UPG  B 403 (-2.7A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.70A 5vncC-4xsrB:
25.4		 5vncC-4xsrB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLN B   8
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 None
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.98A 6gneA-4xsrB:
27.5		 6gneA-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY B  13
GLY B  14
ASN B 174
ARG B 208
PRO B 289
 UPG  B 403 ( 4.0A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
 0.73A 6gneA-4xsrB:
27.5		 6gneA-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY B  14
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.79A 6gneA-4xsrB:
27.5		 6gneA-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		6 / 12 GLU B  16
GLN B   8
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 None
None
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 1.12A 6gneB-4xsrB:
27.4		 6gneB-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		7 / 12 GLU B  16
GLY B  13
GLY B  14
ASN B 174
ARG B 208
PRO B 289
GLY B 291
 None
UPG  B 403 ( 4.0A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.88A 6gneB-4xsrB:
27.4		 6gneB-4xsrB:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 174
ARG B 208
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.86A 6gnfA-4xsrB:
12.8		 6gnfA-4xsrB:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ASN B 174
ARG B 208
GLU B 288
PRO B 289
GLY B 291
 UPG  B 403 (-3.2A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.89A 6gnfC-4xsrB:
25.6		 6gnfC-4xsrB:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4xsr ALR3699 PROTEIN
(Nostoc
sp.
PCC
7120) 		7 / 12 GLU B  16
GLY B  14
HIS B 121
ARG B 208
GLU B 288
PRO B 289
GLY B 291
 None
UPG  B 403 (-3.2A)
UPG  B 403 (-3.9A)
UPG  B 403 (-3.6A)
UPG  B 403 (-3.5A)
UPG  B 403 (-3.4A)
UPG  B 403 (-3.7A)
 0.80A 6gngA-4xsrB:
11.1		 6gngA-4xsrB:
22.80