SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xsv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_A_ACTA703_0
(FUMARATE REDUCTASE
FLAVOPROTEIN)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 4 PHE A  71
ASP A  32
ARG A  76
GLU A  75
 GOL  A 403 (-4.0A)
None
None
None
 1.29A 1kf6A-4xsvA:
0.3		 1kf6A-4xsvA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A  31
ARG A  43
GLN A  44
 CTP  A 402 ( 3.9A)
None
None
 0.87A 1tw4A-4xsvA:
undetectable		 1tw4A-4xsvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 CYH A 306
HIS A 307
PHE A 331
 None
C5P  A 401 (-3.4A)
None
 1.18A 3cr4X-4xsvA:
undetectable		 3cr4X-4xsvA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A 248
GLY A 220
GLU A 283
ALA A 288
 None
C5P  A 401 (-3.1A)
None
None
 0.86A 3fpjB-4xsvA:
3.1		 3fpjB-4xsvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 10 PRO A 264
MET A 266
ASP A 148
SER A 191
GLY A 189
 None
 1.14A 3lsfB-4xsvA:
undetectable
3lsfE-4xsvA:
undetectable		 3lsfB-4xsvA:
20.35
3lsfE-4xsvA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 233
PHE A 232
ILE A 245
GLY A 248
VAL A 305
 None
C5P  A 401 (-3.8A)
None
None
None
 1.05A 4nkxC-4xsvA:
undetectable		 4nkxC-4xsvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 233
PHE A 232
ILE A 245
GLY A 248
VAL A 305
 None
C5P  A 401 (-3.8A)
None
None
None
 1.03A 4nkxD-4xsvA:
undetectable		 4nkxD-4xsvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A 249
GLY A 248
GLU A 283
VAL A 284
THR A 272
 None
 1.40A 4x3mA-4xsvA:
undetectable		 4x3mA-4xsvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 MET A  33
ASP A 223
PHE A 222
 None
None
C5P  A 401 (-3.9A)
 1.06A 4xeyB-4xsvA:
undetectable		 4xeyB-4xsvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ILE A 286
LEU A 296
HIS A 299
PHE A 331
 None
 1.06A 5vkqA-4xsvA:
undetectable
5vkqB-4xsvA:
undetectable		 5vkqA-4xsvA:
11.71
5vkqB-4xsvA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 6 PHE A 331
ILE A 286
LEU A 296
HIS A 299
 None
 1.05A 5vkqA-4xsvA:
undetectable
5vkqD-4xsvA:
undetectable		 5vkqA-4xsvA:
11.71
5vkqD-4xsvA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 8 THR A 125
THR A 117
PRO A  94
LYS A  66
 None
None
None
CTP  A 402 ( 4.8A)
 1.33A 5x2sI-4xsvA:
undetectable
5x2sJ-4xsvA:
undetectable
5x2sK-4xsvA:
undetectable		 5x2sI-4xsvA:
17.72
5x2sJ-4xsvA:
19.69
5x2sK-4xsvA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  55
GLY A  29
THR A 101
TYR A 105
TYR A 126
 None
CTP  A 402 (-3.4A)
None
None
None
 1.02A 5yf0A-4xsvA:
undetectable		 5yf0A-4xsvA:
20.30