SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FXH_B_PACB1001_0 (PENICILLIN ACYLASE)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	4 / 7	PHE F 419 PHE F 427 ALA F 120 ILE F 123	None	0.97A	1fxhA-4xsyF: undetectable 1fxhB-4xsyF: 2.7	1fxhA-4xsyF: 16.44 1fxhB-4xsyF: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_A_AICA5001_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	4 / 8	GLU F 139 GLN F 346 SER F 272 TYR F 268	None	1.32A	1nx9A-4xsyF: undetectable	1nx9A-4xsyF: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_B_AICB5002_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	4 / 8	GLU F 139 GLN F 346 SER F 272 TYR F 268	None	1.33A	1nx9B-4xsyF: undetectable	1nx9B-4xsyF: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_C_AICC5003_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	4 / 8	GLU F 139 GLN F 346 SER F 272 TYR F 268	None	1.33A	1nx9C-4xsyF: undetectable	1nx9C-4xsyF: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_0 (FATTY ACID-BINDING PROTEIN)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	5 / 12	LEU F 598 LEU F 607 LEU F 595 ALA F 594 HIS F 545	None	1.10A	1tw4A-4xsyF: undetectable	1tw4A-4xsyF: 13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q0I_A_BEZA990_0 (QUINOLONE SIGNAL RESPONSE PROTEIN)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	4 / 8	ASP F 313 HIS F 338 SER F 334 HIS F 331	None	1.13A	2q0iA-4xsyF: undetectable	2q0iA-4xsyF: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRH_A_NIOA200_1 (PROTEIN HP0721)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	4 / 7	GLY F 352 ILE F 235 THR F 231 GLN F 357	None	1.02A	2xrhA-4xsyF: undetectable	2xrhA-4xsyF: 11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BRF_A_SORA2_0 (LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A)	4xsy	RNA POLYMERASE SIGMA FACTOR RPOD (Escherichia coli)	3 / 3	LYS F 299 LYS F 289 VAL F 292	None	0.87A	3brfA-4xsyF: undetectable	3brfA-4xsyF: 21.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FXH_B_PACB1001_0","PENICILLIN ACYLASE","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",4,"PHE F 419;PHE F 427;ALA F 120;ILE F 123","None","0.97A","1fxhA-4xsyF:undetectable;1fxhB-4xsyF:2.7","1fxhA-4xsyF:16.44;1fxhB-4xsyF:22.27"],["1NX9_A_AICA5001_1","ALPHA-AMINO ACID ESTER HYDROLASE","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",4,"GLU F 139;GLN F 346;SER F 272;TYR F 268","None","1.32A","1nx9A-4xsyF:undetectable","1nx9A-4xsyF:21.28"],["1NX9_B_AICB5002_1","ALPHA-AMINO ACID ESTER HYDROLASE","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",4,"GLU F 139;GLN F 346;SER F 272;TYR F 268","None","1.33A","1nx9B-4xsyF:undetectable","1nx9B-4xsyF:21.28"],["1NX9_C_AICC5003_1","ALPHA-AMINO ACID ESTER HYDROLASE","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",4,"GLU F 139;GLN F 346;SER F 272;TYR F 268","None","1.33A","1nx9C-4xsyF:undetectable","1nx9C-4xsyF:21.28"],["1TW4_A_CHDA130_0","FATTY ACID-BINDING PROTEIN","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",5,"LEU F 598;LEU F 607;LEU F 595;ALA F 594;HIS F 545","None","1.10A","1tw4A-4xsyF:undetectable","1tw4A-4xsyF:13.95"],["2Q0I_A_BEZA990_0","QUINOLONE SIGNAL RESPONSE PROTEIN","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",4,"ASP F 313;HIS F 338;SER F 334;HIS F 331","None","1.13A","2q0iA-4xsyF:undetectable","2q0iA-4xsyF:20.98"],["2XRH_A_NIOA200_1","PROTEIN HP0721","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",4,"GLY F 352;ILE F 235;THR F 231;GLN F 357","None","1.02A","2xrhA-4xsyF:undetectable","2xrhA-4xsyF:11.78"],["3BRF_A_SORA2_0","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","4xsy","RNA POLYMERASE SIGMA FACTOR RPOD","Escherichia coli",3,"LYS F 299;LYS F 289;VAL F 292","None","0.87A","3brfA-4xsyF:undetectable","3brfA-4xsyF:21.44"]]