SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 8 SER A 148
ASN A  74
ASP A 128
THR A 123
 None
UNL  A 413 ( 3.9A)
UNL  A 412 ( 4.2A)
SIN  A 416 (-3.6A)
 1.14A 1ig3A-4xt1A:
undetectable
1ig3B-4xt1A:
undetectable		 1ig3A-4xt1A:
19.67
1ig3B-4xt1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 VAL A  42
GLY A  41
VAL A  43
TRP A  89
 None
UNL  A 414 ( 4.4A)
None
None
 1.17A 1tkqB-4xt1A:
undetectable		 1tkqB-4xt1A:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 7 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.07A 2eimC-4xt1A:
0.0
2eimJ-4xt1A:
undetectable		 2eimC-4xt1A:
21.81
2eimJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 TYR A 206
SER A 205
TYR A 209
ARG A 210
 UNL  A 409 ( 4.7A)
OLC  A 406 ( 4.0A)
OLC  A 407 ( 3.7A)
OLC  A 407 (-4.8A)
 0.92A 2kqeA-4xt1A:
undetectable		 2kqeA-4xt1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 6 LEU A 305
GLN A 300
LEU A 302
GLU A 301
 None
 1.12A 3h5gB-4xt1A:
undetectable
3h5gC-4xt1A:
undetectable		 3h5gB-4xt1A:
7.24
3h5gC-4xt1A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4xt1 FRACTALKINE
G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus;
Homo
sapiens) 		4 / 6 PHE A  82
VAL B   5
THR A  36
PHE A 281
 None
 1.17A 3ltwA-4xt1A:
undetectable		 3ltwA-4xt1A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		5 / 12 VAL C   2
ALA C  24
MET C  34
VAL C  78
ALA C  97
 None
 0.91A 3qxtA-4xt1C:
19.3		 3qxtA-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		7 / 12 VAL C   2
LEU C   4
ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
 None
 0.88A 3qxtB-4xt1C:
19.5		 3qxtB-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		7 / 12 VAL C   2
ALA C  24
MET C  34
ASN C  73
VAL C  78
ALA C  97
TYR C 107
 None
 0.92A 3qxvA-4xt1C:
18.9		 3qxvA-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		6 / 12 VAL C   2
ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
 None
 0.94A 3qxvB-4xt1C:
18.9		 3qxvB-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		6 / 11 VAL C   2
ALA C  24
MET C  34
ASN C  73
VAL C  78
ALA C  97
 None
 0.89A 3qxvC-4xt1C:
19.3		 3qxvC-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		6 / 12 VAL C   2
ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
 None
 0.87A 3qxvD-4xt1C:
19.0		 3qxvD-4xt1C:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4xt1 NANOBODY 7
(Vicugna
pacos) 		5 / 12 ALA C  24
MET C  34
VAL C  78
ALA C  97
TYR C 107
 None
 0.87A 3qxvE-4xt1C:
16.2		 3qxvE-4xt1C:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4xt1 FRACTALKINE
(Homo
sapiens) 		4 / 5 GLN B  29
ILE B  40
TYR B  27
GLU B  42
 None
 1.20A 4a99D-4xt1B:
undetectable		 4a99D-4xt1B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
NANOBODY 7
(Cytomegalovirus;
Vicugna
pacos) 		5 / 10 ALA A 132
ILE A 133
ILE A 226
LEU A 230
ILE C 101
 None
 1.31A 4dtaA-4xt1A:
undetectable		 4dtaA-4xt1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4xt1 FRACTALKINE
G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus;
Homo
sapiens) 		5 / 11 THR A 108
PHE A 111
TYR A 112
THR B   6
TYR A  40
 PCA  B   1 ( 3.8A)
None
None
None
None
 1.06A 4g1bB-4xt1A:
undetectable		 4g1bB-4xt1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		5 / 12 TYR A  40
PHE A 116
TRP A 241
TYR A 244
THR A 252
 None
 1.27A 4mbsB-4xt1A:
28.4		 4mbsB-4xt1A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		5 / 12 TYR A  40
TRP A  89
TYR A 244
THR A 252
GLU A 277
 None
 1.17A 4mbsB-4xt1A:
28.4		 4mbsB-4xt1A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		5 / 12 LEU A  80
ASP A  79
SER A 118
ALA A 155
LEU A 107
 None
 1.29A 4nc3A-4xt1A:
23.7		 4nc3A-4xt1A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
NANOBODY 7
(Cytomegalovirus;
Vicugna
pacos) 		5 / 10 ASP A  69
GLU C 104
VAL C 102
ILE C 101
ILE A 125
 None
 1.45A 4qt3A-4xt1A:
undetectable		 4qt3A-4xt1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 6 GLU A 277
TYR A  40
THR A  36
TYR A 112
 None
 1.47A 4qwpA-4xt1A:
0.3		 4qwpA-4xt1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 GLU A 277
TYR A  40
THR A  36
TYR A 112
 None
 1.44A 4qwpB-4xt1A:
undetectable		 4qwpB-4xt1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 ILE A 204
VAL A 203
CYH A 120
HIS A 283
 None
UNL  A 409 ( 4.2A)
SIN  A 416 ( 4.0A)
None
 1.33A 4rzvA-4xt1A:
undetectable		 4rzvA-4xt1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 8 HIS A 162
TYR A 112
LEU A 188
THR A 252
 None
 1.11A 5hs6A-4xt1A:
undetectable		 5hs6A-4xt1A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.16A 5iy5P-4xt1A:
0.0
5iy5W-4xt1A:
undetectable		 5iy5P-4xt1A:
20.78
5iy5W-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.17A 5x1fC-4xt1A:
0.0
5x1fJ-4xt1A:
undetectable		 5x1fC-4xt1A:
21.81
5x1fJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.19A 5xdxC-4xt1A:
0.0
5xdxJ-4xt1A:
undetectable		 5xdxC-4xt1A:
20.61
5xdxJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.16A 5xdxP-4xt1A:
0.0
5xdxW-4xt1A:
undetectable		 5xdxP-4xt1A:
20.61
5xdxW-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		5 / 12 CYH A 120
SER A 118
ILE A 158
LEU A  75
TYR A 291
 SIN  A 416 ( 4.0A)
None
None
None
None
 1.36A 5ycpA-4xt1A:
undetectable		 5ycpA-4xt1A:
14.61