SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		4 / 7 ILE A 210
GLY A 211
ASN A 217
ARG A  99
 None
 1.01A 1oniG-4xtkA:
undetectable
1oniI-4xtkA:
undetectable		 1oniG-4xtkA:
17.50
1oniI-4xtkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		4 / 7 GLU A 276
TYR A 275
LEU A 279
THR A 195
 None
 1.10A 1rmtB-4xtkA:
undetectable		 1rmtB-4xtkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		5 / 10 VAL A 236
PHE A 271
VAL A 235
THR A 196
THR A 195
 None
 1.46A 1ydaA-4xtkA:
undetectable		 1ydaA-4xtkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		5 / 11 VAL A 236
PHE A 271
VAL A 235
THR A 196
THR A 195
 None
 1.44A 1ydbA-4xtkA:
undetectable		 1ydbA-4xtkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		5 / 10 VAL A 236
PHE A 271
VAL A 235
THR A 196
THR A 195
 None
 1.46A 1yddA-4xtkA:
undetectable		 1yddA-4xtkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		4 / 8 GLU A 148
LEU A 213
SER A 110
LEU A 230
 None
 1.09A 2q0iA-4xtkA:
undetectable		 2q0iA-4xtkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		4 / 6 LEU A  54
LEU A  51
ILE A  19
ARG A  14
 None
 0.96A 2rlfA-4xtkA:
undetectable
2rlfB-4xtkA:
undetectable		 2rlfA-4xtkA:
10.19
2rlfB-4xtkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		4 / 6 LEU A  54
LEU A  51
ILE A  19
ARG A  14
 None
 0.92A 2rlfC-4xtkA:
undetectable
2rlfD-4xtkA:
undetectable		 2rlfC-4xtkA:
10.19
2rlfD-4xtkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		3 / 3 TYR A  93
GLY A 211
ASP A 226
 None
 0.67A 3ou6C-4xtkA:
undetectable		 3ou6C-4xtkA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		3 / 3 ARG A 295
ASP A  37
ARG A 280
 None
 0.83A 4mx0A-4xtkA:
undetectable		 4mx0A-4xtkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		4 / 6 THR A 216
LEU A 309
LEU A 302
GLU A 301
 None
 1.03A 4nc3A-4xtkA:
undetectable		 4nc3A-4xtkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Thermotoga
maritima) 		5 / 11 VAL A  44
PHE A  50
ILE A  59
ILE A  19
LEU A   6
 None
 0.98A 5e4dB-4xtkA:
undetectable		 5e4dB-4xtkA:
19.28