SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xtl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 4 THR A 216
LEU A 217
VAL A 246
LEU A 245
 LFA  A 330 (-3.6A)
LFA  A 330 ( 4.8A)
None
None
 0.90A 1mz9D-4xtlA:
undetectable		 1mz9D-4xtlA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 4 LEU A 121
LEU A  63
SER A  64
LEU A 262
 None
None
LYR  A 255 ( 4.9A)
None
 1.08A 1ya3A-4xtlA:
undetectable		 1ya3A-4xtlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 8 GLY A 259
LEU A 261
LEU A 262
ILE A 207
 LYR  A 255 ( 3.6A)
None
None
None
 0.88A 3nbqB-4xtlA:
undetectable		 3nbqB-4xtlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 8 GLY A 259
LEU A 261
LEU A 262
ILE A 207
 LYR  A 255 ( 3.6A)
None
None
None
 0.88A 3nbqC-4xtlA:
undetectable		 3nbqC-4xtlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 8 LEU A 204
THR A 268
LEU A 269
LEU A 265
 None
 0.68A 4z90F-4xtlA:
3.4
4z90G-4xtlA:
3.4
4z90H-4xtlA:
3.1
4z90I-4xtlA:
3.0
4z90J-4xtlA:
2.9		 4z90F-4xtlA:
22.09
4z90G-4xtlA:
22.09
4z90H-4xtlA:
22.09
4z90I-4xtlA:
22.09
4z90J-4xtlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 8 ASN A  81
SER A  29
TRP A  82
TYR A  25
 None
None
None
NA  A 301 (-4.7A)
 1.43A 5amiB-4xtlA:
undetectable		 5amiB-4xtlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		4 / 7 ILE A 150
TRP A 113
ASP A 251
SER A 214
 None
LYR  A 255 ( 4.1A)
LYR  A 255 ( 3.8A)
None
 1.30A 5nr3A-4xtlA:
undetectable		 5nr3A-4xtlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4xtl SODIUM PUMPING
RHODOPSIN
(Dokdonia
eikasta) 		5 / 10 ILE A 181
PHE A 211
PHE A 122
LEU A  63
LEU A 262
 None
None
LFA  A 319 ( 4.5A)
None
None
 1.25A 5y7pB-4xtlA:
undetectable		 5y7pB-4xtlA:
24.18