SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4xul MG662
(Megavirus
chiliensis) 		5 / 12 ILE A 317
GLU A 346
VAL A 342
ALA A 350
PHE A 312
 None
 1.41A 2jj8C-4xulA:
undetectable		 2jj8C-4xulA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4xul MG662
(Megavirus
chiliensis) 		5 / 12 ARG A  53
ARG A  30
VAL A  29
ASP A  61
ILE A  62
 None
None
None
MG  A 402 (-2.4A)
None
 1.46A 3jb3A-4xulA:
undetectable		 3jb3A-4xulA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xul MG662
(Megavirus
chiliensis) 		4 / 8 TYR A 203
VAL A  59
VAL A  56
ILE A  20
 None
 1.08A 4aftD-4xulA:
undetectable
4aftE-4xulA:
undetectable		 4aftD-4xulA:
20.00
4aftE-4xulA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4xul MG662
(Megavirus
chiliensis) 		4 / 5 LYS A  83
LEU A  84
GLU A  80
LEU A  39
 None
 1.02A 4k4yA-4xulA:
undetectable		 4k4yA-4xulA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4xul MG662
(Megavirus
chiliensis) 		4 / 4 LYS A  83
LEU A  84
GLU A  80
LEU A  39
 None
 1.01A 4k4yE-4xulA:
undetectable		 4k4yE-4xulA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4xul MG662
(Megavirus
chiliensis) 		4 / 5 LYS A  83
LEU A  84
GLU A  80
LEU A  39
 None
 1.07A 4k4yI-4xulA:
undetectable		 4k4yI-4xulA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4xul MG662
(Megavirus
chiliensis) 		4 / 7 ASN A  76
GLU A  75
GLU A 187
TYR A  78
 None
 1.21A 4mj8C-4xulA:
undetectable		 4mj8C-4xulA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 4xul MG662
(Megavirus
chiliensis) 		5 / 9 VAL A 342
LEU A 339
ILE A 278
PHE A 312
SER A 314
 None
 1.18A 5tixA-4xulA:
undetectable		 5tixA-4xulA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4xul MG662
(Megavirus
chiliensis) 		4 / 7 VAL A  29
ARG A  55
TYR A  21
GLU A  26
 None
 1.09A 5umwB-4xulA:
undetectable
5umwE-4xulA:
0.8		 5umwB-4xulA:
14.17
5umwE-4xulA:
14.17