SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 6 THR A 248
LEU A 276
GLY A 279
TYR A 242
 None
 1.30A 1gtiC-4xupA:
undetectable		 1gtiC-4xupA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 ILE A 288
ALA A 269
ILE A 297
LEU A 225
PRO A 226
 None
 1.21A 1re7B-4xupA:
undetectable		 1re7B-4xupA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 11 LEU A 225
LEU A 228
LEU A 173
ILE A 297
THR A 332
 None
 1.34A 2qd3A-4xupA:
undetectable		 2qd3A-4xupA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		3 / 3 TRP A 118
GLN A  41
TRP A  24
 None
 1.17A 2vqyA-4xupA:
undetectable		 2vqyA-4xupA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 THR A 330
ILE A 288
ASP A 287
ALA A 286
ILE A 284
 None
 1.15A 3ddyA-4xupA:
undetectable		 3ddyA-4xupA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		3 / 3 ASN A 108
ALA A 109
LYS A  90
 None
 0.63A 3runA-4xupA:
undetectable		 3runA-4xupA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 10 LEU A 225
LEU A 228
LEU A 173
ILE A 297
THR A 332
 None
 1.41A 4mk4A-4xupA:
undetectable		 4mk4A-4xupA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		3 / 3 TYR A 146
GLY A  57
PRO A  58
 None
 0.73A 4qwpA-4xupA:
undetectable		 4qwpA-4xupA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 GLU A 195
ALA A 176
PHE A 174
VAL A 327
PHE A 238
 None
 0.85A 4u8yB-4xupA:
undetectable		 4u8yB-4xupA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 LEU A 173
ILE A 329
ILE A 236
ILE A 288
VAL A 290
 None
 1.00A 4y0rA-4xupA:
undetectable		 4y0rA-4xupA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 5 GLY A 199
ARG A 206
GLY A 201
GLU A 179
 None
None
CA  A1002 ( 4.8A)
CA  A1002 (-3.3A)
 1.13A 4z2eB-4xupA:
undetectable
4z2eC-4xupA:
undetectable		 4z2eB-4xupA:
21.41
4z2eC-4xupA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		4 / 7 ILE A 288
PHE A 271
VAL A 234
ILE A 329
 None
 0.88A 4zzbC-4xupA:
undetectable
4zzbD-4xupA:
undetectable		 4zzbC-4xupA:
21.05
4zzbD-4xupA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4xup ENDO-1,4-BETA-XYLANA
SE C
(Paenibacillus
barcinonensis) 		5 / 12 ASP A 141
ALA A 144
SER A  59
THR A  25
TYR A 136
 None
 1.22A 5hfjE-4xupA:
undetectable		 5hfjE-4xupA:
21.52