SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xuv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		3 / 3 ALA A  74
HIS A  75
VAL A  78
 None
 0.25A 1lqtB-4xuvA:
undetectable		 1lqtB-4xuvA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		3 / 3 ALA A  74
HIS A  75
VAL A  78
 None
 0.24A 1lquB-4xuvA:
undetectable		 1lquB-4xuvA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 4 HIS A 202
ALA A 217
PHE A 201
GLY A 203
 None
 1.41A 1mj2B-4xuvA:
undetectable		 1mj2B-4xuvA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 4 HIS A 202
ALA A 217
PHE A 201
GLY A 203
 None
 1.43A 1mjoD-4xuvA:
undetectable		 1mjoD-4xuvA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 6 GLY A 296
TRP A 227
ALA A 293
SER A 292
 None
 1.00A 1p6kA-4xuvA:
undetectable		 1p6kA-4xuvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		3 / 3 LEU A 103
LEU A  60
MET A 368
 None
 0.69A 1ya3B-4xuvA:
undetectable		 1ya3B-4xuvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		3 / 3 ARG A 375
GLU A 234
TYR A 309
 None
 0.79A 3k37B-4xuvA:
undetectable		 3k37B-4xuvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 11 LEU A 158
THR A 157
VAL A 162
LEU A 186
PHE A 252
 None
 1.26A 3tbgA-4xuvA:
undetectable		 3tbgA-4xuvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 10 LEU A 158
THR A 157
VAL A 162
LEU A 186
PHE A 252
 None
 1.23A 3tbgC-4xuvA:
undetectable		 3tbgC-4xuvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 12 LEU A 238
LEU A 172
GLY A 173
ILE A 168
ALA A 106
 None
 1.07A 3uwlD-4xuvA:
undetectable		 3uwlD-4xuvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 5 TRP A  52
GLY A  90
ALA A  89
PHE A  83
 None
 1.49A 3wqwA-4xuvA:
undetectable		 3wqwA-4xuvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 8 PRO A 233
PRO A 164
GLN A  65
ILE A 230
 None
 1.03A 4iilA-4xuvA:
undetectable		 4iilA-4xuvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 8 ALA A 181
PHE A 252
THR A 256
PHE A 200
 None
 1.00A 4ltwA-4xuvA:
undetectable		 4ltwA-4xuvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 10 GLY A 169
VAL A 170
VAL A 178
LEU A 103
LEU A 239
 None
 1.01A 4yb6A-4xuvA:
undetectable
4yb6E-4xuvA:
undetectable		 4yb6A-4xuvA:
21.30
4yb6E-4xuvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 10 GLY A 169
VAL A 170
VAL A 178
LEU A 103
LEU A 239
 None
 0.98A 4yb6B-4xuvA:
undetectable
4yb6C-4xuvA:
undetectable		 4yb6B-4xuvA:
21.30
4yb6C-4xuvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 10 LEU A 103
LEU A 239
GLY A 169
VAL A 170
VAL A 178
 None
 0.99A 4yb6B-4xuvA:
undetectable
4yb6F-4xuvA:
undetectable		 4yb6B-4xuvA:
21.30
4yb6F-4xuvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 12 LEU A 238
LEU A 172
GLY A 173
ILE A 168
ALA A 106
 None
 1.09A 5j7wC-4xuvA:
undetectable		 5j7wC-4xuvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 12 LEU A 238
LEU A 172
GLY A 173
ILE A 168
ALA A 106
 None
 1.09A 5j7wD-4xuvA:
undetectable		 5j7wD-4xuvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 7 LEU A 257
ILE A  58
MET A 365
TRP A 227
 None
 1.04A 5ljcA-4xuvA:
undetectable		 5ljcA-4xuvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		3 / 3 MET A 317
GLU A 262
ARG A 265
 None
 1.05A 5tjyA-4xuvA:
undetectable		 5tjyA-4xuvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		3 / 3 MET A 317
GLU A 262
ARG A 265
 None
 1.06A 5tjzA-4xuvA:
undetectable		 5tjzA-4xuvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		4 / 6 LEU A  20
VAL A 108
MET A 365
GLY A 362
 None
 1.03A 6hd4B-4xuvA:
undetectable		 6hd4B-4xuvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 12 LEU A 238
LEU A 172
GLY A 173
ILE A 168
ALA A 106
 None
 1.10A 6qxsD-4xuvA:
undetectable		 6qxsD-4xuvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 12 LEU A 238
LEU A 172
GLY A 173
ILE A 168
ALA A 106
 None
 1.06A 6qyaB-4xuvA:
undetectable		 6qyaB-4xuvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN
(Thielavia
terrestris) 		5 / 12 LEU A 238
LEU A 172
GLY A 173
ILE A 168
ALA A 106
 None
 1.05A 6qyaD-4xuvA:
undetectable		 6qyaD-4xuvA:
22.54