SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		5 / 11 ALA A 280
ILE A 290
GLY A 289
ILE A 259
ILE A 244
 None
 0.90A 1sduA-4xuyA:
undetectable		 1sduA-4xuyA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		4 / 6 SER A  74
VAL A  96
TYR A 145
ASP A  48
 None
 1.48A 2x45A-4xuyA:
undetectable		 2x45A-4xuyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		5 / 11 GLY A 246
ALA A 205
ILE A 244
ALA A 280
GLN A 284
 None
 1.21A 3nmuB-4xuyA:
undetectable
3nmuJ-4xuyA:
undetectable		 3nmuB-4xuyA:
23.53
3nmuJ-4xuyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		5 / 12 HIS A 137
VAL A 133
TRP A 120
HIS A 109
LEU A 117
 None
 1.48A 3wfhA-4xuyA:
undetectable
3wfhB-4xuyA:
undetectable		 3wfhA-4xuyA:
21.89
3wfhB-4xuyA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		5 / 12 HIS A 137
VAL A 133
TRP A 120
HIS A 109
LEU A 117
 None
 1.49A 3whxA-4xuyA:
undetectable
3whxB-4xuyA:
undetectable		 3whxA-4xuyA:
21.50
3whxB-4xuyA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		3 / 3 TRP A 301
VAL A 292
TRP A 293
 None
 1.05A 3zq8C-4xuyA:
undetectable
3zq8D-4xuyA:
undetectable		 3zq8C-4xuyA:
3.68
3zq8D-4xuyA:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		5 / 12 PHE A  35
ILE A 290
LEU A 309
ASN A  45
ALA A 269
 None
 1.19A 4eb4B-4xuyA:
undetectable		 4eb4B-4xuyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		3 / 3 TYR A  42
ALA A 151
TYR A 150
 None
 0.70A 5uunB-4xuyA:
undetectable		 5uunB-4xuyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		5 / 12 LEU A 236
THR A 234
VAL A 261
SER A 232
SER A 206
 None
 1.27A 5v1tA-4xuyA:
4.9		 5v1tA-4xuyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C
(Aspergillus
niger) 		4 / 7 ALA A 324
ASP A 311
ASP A  65
ILE A  61
 None
None
PCA  A  26 ( 4.2A)
PCA  A  26 ( 4.5A)
 0.97A 6fbnA-4xuyA:
undetectable		 6fbnA-4xuyA:
22.36