SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		3 / 3 THR A  67
PRO A  90
THR A  89
 None
 0.94A 1dscC-4xv0A:
undetectable		 1dscC-4xv0A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		3 / 3 THR A  89
THR A  67
PRO A  90
 None
 0.80A 1dscC-4xv0A:
undetectable		 1dscC-4xv0A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 10 GLY A 260
GLN A 295
VAL A 296
ILE A 285
GLY A 258
 None
 1.46A 1fohC-4xv0A:
undetectable		 1fohC-4xv0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 10 GLY A 260
GLN A 295
VAL A 296
ILE A 285
GLY A 258
 None
 1.46A 1fohD-4xv0A:
undetectable		 1fohD-4xv0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 10 GLY A 260
GLN A 295
VAL A 296
ILE A 285
GLY A 258
 None
 1.47A 1pn0C-4xv0A:
0.7		 1pn0C-4xv0A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		4 / 5 VAL A 311
THR A 310
GLN A  87
ILE A  81
 None
 1.44A 1ss4A-4xv0A:
undetectable		 1ss4A-4xv0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 12 SER A 253
SER A 251
GLY A 260
LEU A 255
VAL A 229
 None
 1.18A 1vpoH-4xv0A:
undetectable
1vpoL-4xv0A:
undetectable		 1vpoH-4xv0A:
20.90
1vpoL-4xv0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 12 THR A 291
GLY A 260
GLY A 259
GLY A 257
GLN A 298
 None
 1.18A 1wg8A-4xv0A:
undetectable		 1wg8A-4xv0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 12 THR A 291
GLY A 260
GLY A 259
GLY A 257
GLN A 298
 None
 1.17A 1wg8B-4xv0A:
undetectable		 1wg8B-4xv0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		3 / 3 TRP A 320
VAL A 311
TRP A 312
 None
 0.94A 3zq8C-4xv0A:
undetectable
3zq8D-4xv0A:
undetectable		 3zq8C-4xv0A:
4.23
3zq8D-4xv0A:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		4 / 7 PRO A 289
ILE A 285
GLY A 260
VAL A 296
 None
 0.90A 4a3uB-4xv0A:
10.2		 4a3uB-4xv0A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		3 / 3 ASP A  68
TRP A 132
SER A  98
 None
 0.93A 4lrhB-4xv0A:
undetectable		 4lrhB-4xv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		3 / 3 ASP A  68
TRP A 132
SER A  98
 None
 0.93A 4lrhF-4xv0A:
undetectable		 4lrhF-4xv0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		5 / 12 VAL A 244
ILE A 216
VAL A 174
VAL A 157
ALA A 205
 GOL  A 411 (-4.4A)
None
None
None
None
 1.46A 4m11D-4xv0A:
undetectable		 4m11D-4xv0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4xv0 BETA-XYLANASE
(Trichoderma
reesei) 		4 / 8 ILE A 342
THR A 294
THR A 263
SER A 302
 None
 0.94A 6c06C-4xv0A:
undetectable		 6c06C-4xv0A:
undetectable