SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		4 / 4 ILE A 345
MET A 310
VAL A 437
GLY A 346
 None
 1.21A 1e06B-4xvmA:
undetectable		 1e06B-4xvmA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 10 VAL A 653
LEU A 644
TYR A 715
VAL A 681
PHE A 654
 None
 1.38A 1fdwA-4xvmA:
undetectable		 1fdwA-4xvmA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 ILE A 541
ILE A 605
GLU A 534
TYR A 535
ILE A 531
 None
 1.11A 1jtxA-4xvmA:
undetectable		 1jtxA-4xvmA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		4 / 7 GLN A 564
PHE A 807
MET A 438
ALA A 436
 None
 0.96A 1linA-4xvmA:
undetectable		 1linA-4xvmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 LEU A 306
VAL A 305
THR A 224
PHE A 197
ASN A 394
 None
 1.19A 2y00B-4xvmA:
undetectable		 2y00B-4xvmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 LEU A 306
VAL A 305
THR A 224
PHE A 197
ASN A 394
 None
 1.17A 2y01B-4xvmA:
undetectable		 2y01B-4xvmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		4 / 6 GLU A 628
THR A 567
ALA A 772
ALA A 773
 None
 0.93A 3ns1C-4xvmA:
undetectable		 3ns1C-4xvmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 LEU A 842
ILE A 631
PHE A 654
TYR A 682
TYR A 686
 None
 1.41A 4a79A-4xvmA:
undetectable		 4a79A-4xvmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 LEU A 842
ILE A 631
PHE A 654
TYR A 682
TYR A 686
 None
 1.40A 4a79B-4xvmA:
undetectable		 4a79B-4xvmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 11 LEU A 842
ILE A 631
PHE A 654
TYR A 682
TYR A 686
 None
 1.38A 4a7aA-4xvmA:
undetectable		 4a7aA-4xvmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 11 ASP A 623
VAL A 821
ALA A 818
PHE A 807
SER A 847
 None
 1.21A 4mmaA-4xvmA:
undetectable		 4mmaA-4xvmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 LEU A 846
SER A 845
ILE A 814
HIS A 854
VAL A 809
 None
 1.12A 5dpdA-4xvmA:
3.8		 5dpdA-4xvmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 PHE A 197
TYR A 282
GLU A 286
ILE A 285
GLY A 246
 None
 1.16A 5ifuA-4xvmA:
undetectable		 5ifuA-4xvmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		5 / 12 TYR A 282
GLU A 286
ILE A 285
GLY A 246
TYR A 385
 None
 1.12A 5ifuA-4xvmA:
undetectable		 5ifuA-4xvmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4xvm DNA POLYMERASE NU
(Homo
sapiens) 		4 / 8 ILE A 356
LEU A 420
LEU A 423
PRO A 358
 None
 0.94A 5u4sB-4xvmA:
undetectable		 5u4sB-4xvmA:
17.36