SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PHE A 109
 None
 1.24A 1d4sA-4xvoA:
undetectable		 1d4sA-4xvoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 1.02A 1d4sA-4xvoA:
undetectable		 1d4sA-4xvoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASN A 236
MET A 160
GLY A 161
THR A 167
GLY A 212
 PO4  A 501 (-3.5A)
None
None
None
None
 0.95A 1jr1A-4xvoA:
undetectable		 1jr1A-4xvoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 236
GLY A 161
THR A 167
GLY A 212
 PO4  A 501 (-3.5A)
None
None
None
 0.87A 1jr1B-4xvoA:
undetectable		 1jr1B-4xvoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.89A 1muiB-4xvoA:
undetectable		 1muiB-4xvoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 188
GLY A 161
ALA A 158
SER A 159
HIS A 216
 None
None
None
None
PO4  A 501 (-4.0A)
 1.33A 1nbhA-4xvoA:
undetectable		 1nbhA-4xvoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 188
GLY A 161
ALA A 158
SER A 159
HIS A 216
 None
None
None
None
PO4  A 501 (-4.0A)
 1.32A 1nbhC-4xvoA:
undetectable		 1nbhC-4xvoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 188
GLY A 161
ALA A 158
SER A 159
HIS A 216
 None
None
None
None
PO4  A 501 (-4.0A)
 1.32A 1nbhD-4xvoA:
undetectable		 1nbhD-4xvoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.93A 1sguB-4xvoA:
undetectable		 1sguB-4xvoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.90A 2aquB-4xvoA:
undetectable		 2aquB-4xvoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.86A 2nmyA-4xvoA:
undetectable		 2nmyA-4xvoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 1.00A 2o4pA-4xvoA:
undetectable		 2o4pA-4xvoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.92A 2q5kB-4xvoA:
undetectable		 2q5kB-4xvoA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.90A 3ekqA-4xvoA:
undetectable		 3ekqA-4xvoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.93A 3ekwA-4xvoA:
undetectable		 3ekwA-4xvoA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A 107
ALA A  91
ASP A  88
PRO A  63
 None
 0.81A 3el9A-4xvoA:
undetectable		 3el9A-4xvoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.95A 3el9B-4xvoA:
undetectable		 3el9B-4xvoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.93A 3em4A-4xvoA:
undetectable		 3em4A-4xvoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.89A 3em4U-4xvoA:
undetectable		 3em4U-4xvoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.94A 3oxxD-4xvoA:
undetectable		 3oxxD-4xvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 236
GLY A 161
THR A 167
GLY A 212
 PO4  A 501 (-3.5A)
None
None
None
 0.79A 4fo4B-4xvoA:
undetectable		 4fo4B-4xvoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.94A 6dilA-4xvoA:
undetectable		 6dilA-4xvoA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4xvo L,D-TRANSPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 107
ALA A  91
ASP A  88
ILE A  84
PRO A  63
 None
 0.96A 6dj2B-4xvoA:
undetectable		 6dj2B-4xvoA:
16.98