SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.05A 1eta1-4xvxA:
undetectable		 1eta1-4xvxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.08A 1eta2-4xvxA:
undetectable		 1eta2-4xvxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.03A 1etb1-4xvxA:
undetectable		 1etb1-4xvxA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.13A 1f86A-4xvxA:
undetectable		 1f86A-4xvxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.00A 1f86B-4xvxA:
undetectable		 1f86B-4xvxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 120
ILE A 118
VAL A 181
ALA A 221
LEU A 102
 FDA  A 402 (-3.3A)
FDA  A 402 (-4.9A)
None
None
None
 0.99A 1udtA-4xvxA:
undetectable		 1udtA-4xvxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 120
ILE A 118
VAL A 181
ALA A 221
LEU A 102
 FDA  A 402 (-3.3A)
FDA  A 402 (-4.9A)
None
None
None
 1.13A 1xp0A-4xvxA:
undetectable		 1xp0A-4xvxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  93
GLY A 119
ILE A 161
VAL A 220
ILE A  92
 None
FDA  A 402 ( 4.2A)
None
None
None
 1.09A 2avoA-4xvxA:
undetectable		 2avoA-4xvxA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 120
ILE A 118
VAL A 181
ALA A 221
LEU A 102
 FDA  A 402 (-3.3A)
FDA  A 402 (-4.9A)
None
None
None
 1.10A 2h42B-4xvxA:
undetectable		 2h42B-4xvxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.02A 2roxA-4xvxA:
undetectable		 2roxA-4xvxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 295
LEU A 290
GLY A 243
ALA A 246
 None
 0.63A 2xfsA-4xvxA:
undetectable		 2xfsA-4xvxA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 295
LEU A 290
GLY A 243
ALA A 246
 None
 0.63A 2xh9A-4xvxA:
undetectable		 2xh9A-4xvxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  79
ALA A 200
GLN A  32
SER A 155
ILE A 157
 None
 1.31A 3ia4B-4xvxA:
undetectable		 3ia4B-4xvxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  44
GLY A  47
ALA A  51
ALA A  17
ILE A 110
 None
 0.98A 3jayA-4xvxA:
undetectable		 3jayA-4xvxA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 7 SER A 231
LEU A  64
ARG A  95
ILE A  92
 None
 1.07A 3ln1C-4xvxA:
1.0		 3ln1C-4xvxA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 7 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.00A 3ozkB-4xvxA:
undetectable		 3ozkB-4xvxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 ASP A   6
GLY A  47
ALA A  51
ALA A  54
ASP A  56
 None
 1.02A 3sudD-4xvxA:
undetectable		 3sudD-4xvxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  17
VAL A  22
PHE A  35
ILE A  79
HIS A  86
 None
 1.30A 4c49A-4xvxA:
undetectable		 4c49A-4xvxA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 237
GLN A 244
GLY A 243
SER A 240
 None
 0.96A 4f93B-4xvxA:
undetectable		 4f93B-4xvxA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.02A 4ikiB-4xvxA:
undetectable		 4ikiB-4xvxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  77
LEU A  39
PHE A  49
GLY A 243
LEU A  67
 P33  A 401 ( 3.7A)
None
None
None
None
 1.17A 4kykA-4xvxA:
undetectable
4kykB-4xvxA:
undetectable		 4kykA-4xvxA:
16.92
4kykB-4xvxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  22
LEU A  43
VAL A  48
PHE A  18
 None
 1.01A 4lb0B-4xvxA:
undetectable		 4lb0B-4xvxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 6 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.03A 4pwjA-4xvxA:
undetectable		 4pwjA-4xvxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 316
GLY A 355
ILE A 245
VAL A  81
 None
P33  A 401 (-3.4A)
None
P33  A 401 (-4.5A)
 0.77A 4r21A-4xvxA:
undetectable		 4r21A-4xvxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 103
ASP A 100
ASP A 104
ASP A 107
 None
 1.12A 4xqgA-4xvxA:
undetectable		 4xqgA-4xvxA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 103
ASP A 100
ASP A 104
ASP A 107
 None
 1.10A 4xqgB-4xvxA:
undetectable		 4xqgB-4xvxA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 243
GLY A  72
LEU A  71
ALA A 308
LEU A  64
 None
 0.98A 5c0oG-4xvxA:
undetectable		 5c0oG-4xvxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.03A 5cr1A-4xvxA:
undetectable		 5cr1A-4xvxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  40
THR A  26
PHE A  49
LEU A  71
LEU A  74
 None
 1.23A 5fhzC-4xvxA:
undetectable		 5fhzC-4xvxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 351
SER A  76
GLY A  78
GLY A 201
ARG A 347
 P33  A 401 ( 4.0A)
None
None
None
None
 1.21A 5o4yD-4xvxA:
undetectable
5o4yE-4xvxA:
undetectable		 5o4yD-4xvxA:
3.54
5o4yE-4xvxA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 234
VAL A 164
ALA A  91
LEU A  64
LEU A 303
 None
 1.38A 5x23A-4xvxA:
undetectable		 5x23A-4xvxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 291
ALA A 246
GLN A 284
ILE A 253
 None
 1.05A 6g9bA-4xvxA:
undetectable
6g9bB-4xvxA:
undetectable		 6g9bA-4xvxA:
11.34
6g9bB-4xvxA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 291
ALA A 247
GLN A 284
ILE A 253
 None
 1.23A 6g9bA-4xvxA:
undetectable
6g9bB-4xvxA:
undetectable		 6g9bA-4xvxA:
11.34
6g9bB-4xvxA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.00A 6gnrA-4xvxA:
undetectable		 6gnrA-4xvxA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.02A 6gnrB-4xvxA:
undetectable		 6gnrB-4xvxA:
16.45