SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens) 		4 / 6 TYR A 135
GLY A 159
PHE A 165
SER A 174
 None
 0.76A 2a3cA-4xw3A:
undetectable		 2a3cA-4xw3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens) 		4 / 6 TYR A 135
GLY A 159
PHE A 165
SER A 174
 None
 0.84A 2a3cB-4xw3A:
undetectable		 2a3cB-4xw3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens) 		4 / 6 PRO A 229
LEU A 196
ARG A 123
GLY A 164
 None
 1.13A 2hs2B-4xw3A:
undetectable		 2hs2B-4xw3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens) 		3 / 3 SER A 272
TYR A  96
HIS A 271
 None
 0.74A 2r2vD-4xw3A:
undetectable		 2r2vD-4xw3A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens) 		4 / 8 VAL A 232
GLY A 148
SER A 150
GLY A 164
 None
 0.67A 5e26C-4xw3A:
undetectable
5e26D-4xw3A:
undetectable		 5e26C-4xw3A:
21.05
5e26D-4xw3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens) 		5 / 12 LEU A 238
PHE A 167
GLY A 159
PHE A 205
GLY A 164
 None
 0.93A 5veuH-4xw3A:
undetectable		 5veuH-4xw3A:
18.67