SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  90
ALA A 124
ALA A 125
VAL A  96
LEU A 197
 None
 1.28A 1rbpA-4xwiA:
undetectable		 1rbpA-4xwiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 185
TYR A 190
THR A 128
GLN A 216
 None
 1.45A 2vxaF-4xwiA:
undetectable
2vxaG-4xwiA:
undetectable
2vxaI-4xwiA:
undetectable		 2vxaF-4xwiA:
15.35
2vxaG-4xwiA:
15.35
2vxaI-4xwiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A  76
GLY A  77
THR A  78
 None
 0.21A 3k9wA-4xwiA:
3.3		 3k9wA-4xwiA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 134
GLU A 131
ASN A 234
 None
 1.04A 4bupB-4xwiA:
undetectable		 4bupB-4xwiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  82
LEU A 197
ARG A  80
ALA A  72
GLU A  83
 None
 1.49A 4mx0A-4xwiA:
undetectable		 4mx0A-4xwiA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  78
SER A  76
GLY A 188
GLY A 101
PRO A  10
 None
 1.49A 4uinH-4xwiA:
undetectable
4uinL-4xwiA:
undetectable		 4uinH-4xwiA:
21.38
4uinL-4xwiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 127
THR A 128
TYR A 190
HIS A 227
 None
 1.28A 5ecmA-4xwiA:
undetectable		 5ecmA-4xwiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 134
GLU A 131
ASN A 234
 None
 1.00A 5wbvA-4xwiA:
undetectable		 5wbvA-4xwiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4xwi 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 134
GLU A 131
ASN A 234
 None
 1.00A 5wbvB-4xwiA:
undetectable		 5wbvB-4xwiA:
19.21