SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		5 / 10 THR B  59
SER B  37
LEU B  50
VAL B  23
VAL B  35
 None
 1.34A 1q23E-4xwjB:
undetectable		 1q23E-4xwjB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		5 / 11 THR B  59
SER B  37
LEU B  50
VAL B  23
VAL B  35
 None
 1.41A 1q23L-4xwjB:
undetectable		 1q23L-4xwjB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		5 / 9 GLY B  54
GLN B  51
ILE B   8
VAL B  61
VAL B  35
 None
 1.36A 3fi0C-4xwjB:
undetectable		 3fi0C-4xwjB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		5 / 10 THR B  59
SER B  37
LEU B  50
VAL B  23
VAL B  35
 None
 1.38A 3u9fI-4xwjB:
undetectable		 3u9fI-4xwjB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		4 / 6 LEU B  50
LEU B  55
ILE B   8
MET B  81
 None
 0.99A 4do3B-4xwjB:
undetectable		 4do3B-4xwjB:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		4 / 4 SER B  43
ALA B  42
GLN B  51
THR B  52
 None
 1.15A 5n0rA-4xwjB:
undetectable		 5n0rA-4xwjB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		4 / 4 SER B  43
ALA B  42
GLN B  51
THR B  52
 None
 1.13A 5n0sA-4xwjB:
undetectable		 5n0sA-4xwjB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		4 / 4 SER B  43
ALA B  42
GLN B  51
THR B  52
 None
 1.10A 5n0wA-4xwjB:
undetectable		 5n0wA-4xwjB:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		4 / 5 SER B  43
ALA B  42
GLN B  51
THR B  52
 None
 1.11A 5n0wB-4xwjB:
undetectable		 5n0wB-4xwjB:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		4 / 5 SER B  43
ALA B  42
GLN B  51
THR B  52
 None
 1.14A 5n4iA-4xwjB:
undetectable		 5n4iA-4xwjB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		5 / 12 GLY B  67
SER B  31
GLN B   4
LEU B  77
GLU B  75
 None
 1.19A 5nwwA-4xwjB:
undetectable		 5nwwA-4xwjB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4xwj PHOSPHOCARRIER
PROTEIN HPR
(Escherichia
coli) 		5 / 12 VAL B  78
ALA B  82
PHE B  22
LEU B  53
LEU B  50
 None
 1.16A 5tudA-4xwjB:
undetectable		 5tudA-4xwjB:
10.41