SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 5 HIS A 381
HIS A  84
HIS A  89
HIS A 403
ASP A 209
 U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
ZN  A 602 (-3.3A)
ZN  A 602 (-3.2A)
None
 1.38A 1e9yB-4xwtA:
2.9		 1e9yB-4xwtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 9 ALA A  51
GLY A  25
ILE A  34
VAL A 453
ILE A  63
 None
 1.16A 1hpvB-4xwtA:
undetectable		 1hpvB-4xwtA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 HIS A 285
LEU A 110
ALA A 113
LEU A 114
 None
 0.91A 1hwiB-4xwtA:
undetectable		 1hwiB-4xwtA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 HIS A 285
LEU A 110
ALA A 113
LEU A 114
 None
 0.90A 1hwiC-4xwtA:
undetectable		 1hwiC-4xwtA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4xwt DR2417
(Deinococcus
radiodurans) 		3 / 3 ASP A  88
HIS A 153
ASP A 209
 ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
None
 0.76A 1nw5A-4xwtA:
2.6		 1nw5A-4xwtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 LEU A 387
THR A 173
ASP A 175
GLY A 404
HIS A 403
 None
None
ZN  A 602 ( 2.5A)
None
ZN  A 602 (-3.2A)
 1.35A 1v8bA-4xwtA:
undetectable		 1v8bA-4xwtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 LEU A 387
THR A 173
ASP A 175
GLY A 404
HIS A 403
 None
None
ZN  A 602 ( 2.5A)
None
ZN  A 602 (-3.2A)
 1.36A 1v8bD-4xwtA:
2.1		 1v8bD-4xwtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 6 SER A 295
PHE A 241
ARG A 239
GLU A 269
 None
 1.35A 2c8aC-4xwtA:
undetectable		 2c8aC-4xwtA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 HIS A  89
GLY A 174
HIS A 403
HIS A 381
SER A 154
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.2A)
U5P  A 606 (-3.9A)
U5P  A 606 (-3.4A)
 1.22A 2pgfA-4xwtA:
undetectable		 2pgfA-4xwtA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 11 ASP A  88
HIS A  89
HIS A 153
ASP A 175
HIS A 403
 ZN  A 602 (-2.7A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.2A)
 0.61A 2q0jB-4xwtA:
11.2		 2q0jB-4xwtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 TYR A 250
GLU A 222
GLN A 248
HIS A  86
 None
None
None
ZN  A 601 (-3.1A)
 0.84A 3b9lA-4xwtA:
3.1		 3b9lA-4xwtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		6 / 10 ARG A  99
ASP A  88
GLY A  26
GLY A  25
LEU A  24
VAL A 453
 None
ZN  A 602 (-2.7A)
None
None
None
None
 1.12A 3em4V-4xwtA:
undetectable		 3em4V-4xwtA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 LEU A 387
ARG A 215
SER A 190
GLY A 380
 None
None
None
U5P  A 606 (-3.4A)
 0.87A 3hcnA-4xwtA:
4.1		 3hcnA-4xwtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 LEU A 387
ARG A 215
SER A 190
GLY A 380
 None
None
None
U5P  A 606 (-3.4A)
 0.99A 3hcrB-4xwtA:
3.5		 3hcrB-4xwtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 4 PRO A 109
THR A 111
GLY A 174
THR A 173
 None
 1.18A 3ib1A-4xwtA:
undetectable		 3ib1A-4xwtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 6 ILE A  81
TYR A 161
ASP A 209
THR A 394
 None
 1.05A 3q70A-4xwtA:
undetectable		 3q70A-4xwtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 ASP A 175
HIS A 381
ILE A  30
HIS A 403
 ZN  A 602 ( 2.5A)
U5P  A 606 (-3.9A)
None
ZN  A 602 (-3.2A)
 1.02A 3t01A-4xwtA:
2.2		 3t01A-4xwtA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.31A 3w9tA-4xwtA:
undetectable		 3w9tA-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.30A 3w9tB-4xwtA:
undetectable		 3w9tB-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.30A 3w9tC-4xwtA:
undetectable		 3w9tC-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.30A 3w9tD-4xwtA:
undetectable		 3w9tD-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.30A 3w9tE-4xwtA:
undetectable		 3w9tE-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.31A 3w9tF-4xwtA:
undetectable		 3w9tF-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 VAL A 132
GLY A 107
TYR A 134
ASP A 157
 None
 1.29A 3w9tG-4xwtA:
undetectable		 3w9tG-4xwtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 10 HIS A  84
HIS A  86
ASP A  88
HIS A 153
HIS A 403
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.81A 4c1dB-4xwtA:
9.4		 4c1dB-4xwtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 11 HIS A  84
HIS A  86
ASP A  88
HIS A 153
HIS A 403
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.81A 4c1fA-4xwtA:
3.7
4c1fB-4xwtA:
10.3		 4c1fA-4xwtA:
18.93
4c1fB-4xwtA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 9 HIS A  84
HIS A  86
ASP A  88
HIS A 153
HIS A 403
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.80A 4c1hA-4xwtA:
10.9		 4c1hA-4xwtA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 THR A  35
VAL A 435
ASP A 433
VAL A  21
 None
 0.93A 4cp4A-4xwtA:
undetectable		 4cp4A-4xwtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 10 ALA A  51
GLY A  25
ILE A  34
VAL A 453
ILE A  63
 None
 1.08A 4dqcA-4xwtA:
undetectable		 4dqcA-4xwtA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 HIS A  86
ASP A  88
HIS A 153
HIS A 403
 ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.73A 4exsB-4xwtA:
9.5		 4exsB-4xwtA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 ILE A  22
PRO A  23
GLY A  28
ALA A 450
 None
 0.96A 4g0uB-4xwtA:
2.3		 4g0uB-4xwtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 5 HIS A 381
HIS A  84
HIS A  89
HIS A 403
ASP A 209
 U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
ZN  A 602 (-3.3A)
ZN  A 602 (-3.2A)
None
 1.35A 4h9mA-4xwtA:
undetectable		 4h9mA-4xwtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 ALA A 450
ASP A  47
ILE A  34
ILE A  96
 None
 0.87A 4ndnD-4xwtA:
undetectable		 4ndnD-4xwtA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 9 LEU A 206
GLY A 199
ALA A 198
ASP A 201
THR A 173
 None
 1.16A 4njtD-4xwtA:
undetectable		 4njtD-4xwtA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 HIS A 381
HIS A 403
HIS A  84
HIS A  86
 U5P  A 606 (-3.9A)
ZN  A 602 (-3.2A)
ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
 0.95A 4p6sB-4xwtA:
undetectable		 4p6sB-4xwtA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 THR A 394
GLY A 202
ALA A 198
ILE A 162
 None
 0.58A 4txnA-4xwtA:
2.7		 4txnA-4xwtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 THR A 394
GLY A 202
ALA A 198
ILE A 162
 None
 0.59A 4txnB-4xwtA:
undetectable		 4txnB-4xwtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 THR A 394
GLY A 202
ALA A 198
ILE A 162
 None
 0.60A 4txnC-4xwtA:
undetectable		 4txnC-4xwtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 7 THR A 394
GLY A 202
ALA A 198
ILE A 162
 None
 0.58A 4txnD-4xwtA:
undetectable		 4txnD-4xwtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 HIS A  86
ASP A  88
HIS A 153
HIS A 403
 ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.73A 5a5zA-4xwtA:
9.8		 5a5zA-4xwtA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4xwt DR2417
(Deinococcus
radiodurans) 		6 / 11 HIS A  84
HIS A  86
ASP A  88
HIS A  89
HIS A 153
HIS A 403
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.37A 5ayaA-4xwtA:
12.1		 5ayaA-4xwtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4xwt DR2417
(Deinococcus
radiodurans) 		3 / 3 HIS A 153
ASP A 209
HIS A 381
 ZN  A 601 (-3.4A)
None
U5P  A 606 (-3.9A)
 0.96A 5n1tW-4xwtA:
undetectable		 5n1tW-4xwtA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 ASP A 175
HIS A  89
HIS A 403
HIS A 153
 ZN  A 602 ( 2.5A)
ZN  A 602 (-3.3A)
ZN  A 602 (-3.2A)
ZN  A 601 (-3.4A)
 0.94A 5nekD-4xwtA:
undetectable		 5nekD-4xwtA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 ASP A 175
HIS A 153
HIS A  84
HIS A 403
 ZN  A 602 ( 2.5A)
ZN  A 601 (-3.4A)
ZN  A 601 (-3.5A)
ZN  A 602 (-3.2A)
 0.93A 5nekD-4xwtA:
undetectable		 5nekD-4xwtA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		6 / 10 HIS A  84
HIS A  86
HIS A  89
HIS A 153
ASP A 175
HIS A 381
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
U5P  A 606 (-3.9A)
 0.29A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 10 HIS A 153
HIS A  84
HIS A 381
ASP A 175
HIS A 403
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.5A)
U5P  A 606 (-3.9A)
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.2A)
 0.95A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 10 HIS A 153
HIS A 381
HIS A  84
THR A  35
HIS A  89
 ZN  A 601 (-3.4A)
U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
None
ZN  A 602 (-3.3A)
 1.06A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		3 / 3 HIS A  89
ASP A 175
HIS A 403
 ZN  A 602 (-3.3A)
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.2A)
 0.80A 5oexA-4xwtA:
undetectable		 5oexA-4xwtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4xwt DR2417
(Deinococcus
radiodurans) 		3 / 3 GLY A 183
ASN A 254
ARG A 261
 None
 0.76A 5w7bD-4xwtA:
undetectable		 5w7bD-4xwtA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 5 HIS A  86
ASP A 209
GLY A 174
ASN A 158
 ZN  A 601 (-3.1A)
None
None
None
 1.46A 5x7pB-4xwtA:
2.9		 5x7pB-4xwtA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 6 ALA A 277
GLN A 281
GLN A 253
ASP A 257
 None
 1.46A 5y9aA-4xwtA:
undetectable		 5y9aA-4xwtA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 LEU A 361
VAL A 366
VAL A 340
PHE A 241
 None
 0.69A 5y9mX-4xwtA:
undetectable		 5y9mX-4xwtA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 11 HIS A  86
ILE A 155
HIS A  84
HIS A 381
ASP A 179
 ZN  A 601 (-3.1A)
None
ZN  A 601 (-3.5A)
U5P  A 606 (-3.9A)
None
 1.47A 5z0mA-4xwtA:
undetectable
5z0mB-4xwtA:
undetectable		 5z0mA-4xwtA:
9.66
5z0mB-4xwtA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 8 HIS A  86
ASP A  88
HIS A 153
HIS A 403
 ZN  A 601 (-3.1A)
ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.2A)
 0.77A 5zj8A-4xwtA:
9.7		 5zj8A-4xwtA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 LEU A 361
GLY A 327
ILE A 332
VAL A 366
ILE A 364
 None
 0.94A 6dgxA-4xwtA:
undetectable		 6dgxA-4xwtA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 LEU A 361
GLY A 327
ILE A 332
VAL A 366
ILE A 364
 None
 0.94A 6difB-4xwtA:
undetectable		 6difB-4xwtA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4xwt DR2417
(Deinococcus
radiodurans) 		4 / 6 LEU A  93
TYR A 276
GLN A 316
GLU A  87
 None
 1.46A 6djzC-4xwtA:
undetectable		 6djzC-4xwtA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 GLN A 409
ASP A 209
ASN A  33
GLY A  26
HIS A 403
 None
None
ZN  A 602 ( 4.5A)
None
ZN  A 602 (-3.2A)
 1.39A 6exiA-4xwtA:
undetectable		 6exiA-4xwtA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xwt DR2417
(Deinococcus
radiodurans) 		5 / 12 GLN A 409
ASP A 209
ASN A  33
GLY A  26
HIS A 403
 None
None
ZN  A 602 ( 4.5A)
None
ZN  A 602 (-3.2A)
 1.40A 6exiD-4xwtA:
undetectable		 6exiD-4xwtA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4xwt DR2417
(Deinococcus
radiodurans) 		3 / 3 TRP A 402
ILE A  34
ASP A  47
 None
 0.88A 6i0y7-4xwtA:
undetectable		 6i0y7-4xwtA:
4.18