SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A  78
ALA A 168
VAL A  85
VAL A 126
ILE A 194
 None
 1.24A 3dl9A-4xwxA:
undetectable		 3dl9A-4xwxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 155
GLN A 188
ALA A 153
ILE A 194
 None
 0.95A 4txnA-4xwxA:
undetectable		 4txnA-4xwxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 155
GLN A 188
ALA A 153
ILE A 194
 None
 0.92A 4txnB-4xwxA:
undetectable		 4txnB-4xwxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 155
GLN A 188
ALA A 153
ILE A 194
 None
 0.95A 4txnC-4xwxA:
undetectable		 4txnC-4xwxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 155
GLN A 188
ALA A 153
ILE A 194
 None
 0.93A 4txnD-4xwxA:
undetectable		 4txnD-4xwxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		3 / 3 MET A 147
GLU A 199
ARG A 201
 None
 1.11A 5tjyA-4xwxA:
undetectable		 5tjyA-4xwxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		3 / 3 MET A 147
GLU A 199
ARG A 201
 None
 1.10A 5tjzA-4xwxA:
undetectable		 5tjzA-4xwxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4xwx SHC-TRANSFORMING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 150
SER A 149
ALA A 143
LEU A 124
 None
 1.06A 6dwnA-4xwxA:
undetectable		 6dwnA-4xwxA:
18.59