SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		4 / 7 GLN A 343
ALA A 347
ARG A 284
ASN A 291
 None
 1.38A 1t9wA-4xx6A:
undetectable		 1t9wA-4xx6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		4 / 5 VAL A 290
VAL A 289
GLN A 281
PHE A 338
 None
 1.10A 3bjwB-4xx6A:
undetectable		 3bjwB-4xx6A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		4 / 5 PHE A 328
PHE A  69
ILE A 308
GLY A 307
 None
 1.04A 4ejjC-4xx6A:
undetectable		 4ejjC-4xx6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		3 / 3 SER A 313
ASP A 310
GLN A 282
 None
 0.79A 4oltA-4xx6A:
undetectable
4oltB-4xx6A:
undetectable		 4oltA-4xx6A:
22.51
4oltB-4xx6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		5 / 12 ASN A  70
LEU A 327
PHE A 328
PHE A  43
GLY A  44
 P6G  A 426 (-4.0A)
None
None
None
None
 1.35A 4pevC-4xx6A:
undetectable		 4pevC-4xx6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		3 / 3 GLN A 282
SER A 313
ASP A 310
 None
 0.75A 4qwpA-4xx6A:
undetectable
4qwpB-4xx6A:
undetectable		 4qwpA-4xx6A:
22.51
4qwpB-4xx6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		4 / 5 ASP A 203
VAL A 220
PHE A 254
GLY A 231
 None
 1.24A 4xp6A-4xx6A:
undetectable		 4xp6A-4xx6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		5 / 12 THR A 288
LEU A 345
ILE A 268
PHE A 238
THR A  33
 None
 1.49A 5ewjC-4xx6A:
undetectable
5ewjD-4xx6A:
undetectable		 5ewjC-4xx6A:
22.28
5ewjD-4xx6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xx6 BETA-XYLANASE
(Gloeophyllum
trabeum) 		3 / 3 TYR A  42
ALA A 155
TYR A 154
 None
None
P6G  A 426 (-4.4A)
 0.71A 5uunB-4xx6A:
undetectable		 5uunB-4xx6A:
20.22