SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		5 / 12 PRO A  86
GLY A 110
GLY A 111
GLY A 112
HIS A  81
 None
 1.00A 1wg8B-4xxfA:
undetectable		 1wg8B-4xxfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		4 / 8 GLU A 259
SER A 217
HIS A 131
ARG A 134
 None
 0.99A 3b9lA-4xxfA:
undetectable		 3b9lA-4xxfA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		5 / 12 LEU A 209
ALA A 129
ALA A 122
GLY A  69
VAL A 137
 None
 1.10A 3c6gB-4xxfA:
undetectable		 3c6gB-4xxfA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		3 / 3 HIS A 127
HIS A 131
ILE A 130
 None
 0.77A 3u52A-4xxfA:
undetectable
3u52C-4xxfA:
undetectable		 3u52A-4xxfA:
19.64
3u52C-4xxfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_E_ACTE805_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT
ACETONE CARBOXYLASE
BETA SUBUNIT)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		4 / 4 VAL A 211
GLU A 259
ARG A 134
LYS A 199
 None
 1.42A 5m45D-4xxfA:
0.8
5m45E-4xxfA:
0.0		 5m45D-4xxfA:
16.25
5m45E-4xxfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_H_ACTH806_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT
ACETONE CARBOXYLASE
BETA SUBUNIT)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		4 / 4 VAL A 211
GLU A 259
ARG A 134
LYS A 199
 None
 1.41A 5m45G-4xxfA:
0.0
5m45H-4xxfA:
0.0		 5m45G-4xxfA:
16.25
5m45H-4xxfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE
(Glaciozyma
antarctica) 		5 / 12 GLY A 123
ILE A 126
THR A  72
VAL A  84
LEU A 203
 None
 1.43A 5nz0A-4xxfA:
undetectable		 5nz0A-4xxfA:
21.94