SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		5 / 12 ASN A  78
ILE A 310
PRO A 311
GLY A 283
THR A 313
 None
 1.41A 1g60B-4xxhA:
3.2		 1g60B-4xxhA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		4 / 6 LEU A 243
ALA A 239
LEU A 181
SER A 179
 None
 0.95A 1tz8C-4xxhA:
undetectable
1tz8D-4xxhA:
undetectable		 1tz8C-4xxhA:
23.53
1tz8D-4xxhA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		5 / 11 GLY A 246
GLY A 221
SER A  74
LEU A  75
SER A  76
 None
None
T6P  A 401 (-2.6A)
T6P  A 401 (-4.8A)
T6P  A 401 (-2.7A)
 1.01A 2qmmA-4xxhA:
2.6
2qmmB-4xxhA:
4.5		 2qmmA-4xxhA:
21.37
2qmmB-4xxhA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		4 / 5 GLN A 294
ALA A 153
GLN A 307
ILE A 308
 None
 0.88A 2z0aA-4xxhA:
undetectable		 2z0aA-4xxhA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		4 / 7 MET A 270
LEU A 269
GLU A 276
HIS A 274
 None
 1.25A 4aq7A-4xxhA:
3.3		 4aq7A-4xxhA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		5 / 11 PHE A  88
ILE A 296
LEU A  85
ILE A  96
MET A  97
 None
 1.33A 6fgcA-4xxhA:
6.4		 6fgcA-4xxhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER
(Escherichia
coli) 		5 / 11 PHE A  88
ILE A 296
LEU A  85
ILE A  96
MET A  97
 None
 1.38A 6fgdA-4xxhA:
7.1		 6fgdA-4xxhA:
16.39