SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4xxk PHYCOBILIPROTEIN
APCE
(Nostoc
sp.
PCC
7120) 		5 / 9 ALA A 204
GLY A 198
ILE A 192
ILE A  79
ILE A  75
 None
None
CYC  A 301 (-4.3A)
None
None
 0.95A 1hshB-4xxkA:
undetectable		 1hshB-4xxkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4xxk PHYCOBILIPROTEIN
APCE
(Nostoc
sp.
PCC
7120) 		4 / 4 LEU A  54
ILE A  56
GLY A  50
ILE A 225
 None
 0.80A 5dzk3-4xxkA:
undetectable
5dzkm-4xxkA:
undetectable		 5dzk3-4xxkA:
5.56
5dzkm-4xxkA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4xxk PHYCOBILIPROTEIN
APCE
(Nostoc
sp.
PCC
7120) 		4 / 5 ILE A  56
GLY A  50
ILE A 225
LEU A  54
 None
 0.80A 5dzkB-4xxkA:
undetectable
5dzkI-4xxkA:
undetectable
5dzkW-4xxkA:
undetectable		 5dzkB-4xxkA:
22.67
5dzkI-4xxkA:
24.10
5dzkW-4xxkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4xxk PHYCOBILIPROTEIN
APCE
(Nostoc
sp.
PCC
7120) 		4 / 5 ILE A  56
GLY A  50
ILE A 225
LEU A  54
 None
 0.85A 5dzkd-4xxkA:
undetectable
5dzkk-4xxkA:
undetectable
5dzky-4xxkA:
undetectable		 5dzkd-4xxkA:
22.67
5dzkk-4xxkA:
24.10
5dzky-4xxkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4xxk PHYCOBILIPROTEIN
APCE
(Nostoc
sp.
PCC
7120) 		4 / 4 ILE A  56
GLY A  50
ILE A 225
LEU A  54
 None
 0.75A 5dzkl-4xxkA:
undetectable
5dzkz-4xxkA:
undetectable		 5dzkl-4xxkA:
24.10
5dzkz-4xxkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4xxk PHYCOBILIPROTEIN
APCE
(Nostoc
sp.
PCC
7120) 		4 / 6 ARG A  37
PHE A  34
ILE A  25
THR A  24
 None
 0.96A 5vceA-4xxkA:
undetectable		 5vceA-4xxkA:
15.82