SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  63
ILE A 195
ARG A  67
LEU A  60
 None
 0.96A 2xrhA-4xxnA:
undetectable		 2xrhA-4xxnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 185
LEU A 188
ASP A 189
 None
 0.24A 3ko0A-4xxnA:
undetectable		 3ko0A-4xxnA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 185
LEU A 188
ASP A 189
 None
 0.18A 3ko0T-4xxnA:
undetectable		 3ko0T-4xxnA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 123
VAL A 122
GLN A  47
 None
 0.71A 3of4B-4xxnA:
undetectable		 3of4B-4xxnA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 125
THR A 124
ALA A 123
THR A  40
 None
None
None
CL  A 501 (-4.1A)
 0.97A 4qw0K-4xxnA:
undetectable		 4qw0K-4xxnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 125
THR A 124
ALA A 123
THR A  40
 None
None
None
CL  A 501 (-4.1A)
 0.97A 4qw0Y-4xxnA:
undetectable		 4qw0Y-4xxnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.17A 5eb5A-4xxnA:
undetectable		 5eb5A-4xxnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  41
ALA A 268
VAL A 212
LEU A 140
HIS A 216
 None
 1.17A 5eb5B-4xxnA:
undetectable		 5eb5B-4xxnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		5 / 12 PRO A  28
LEU A  60
PHE A 159
GLY A 155
HIS A 151
 None
 1.04A 5l6eA-4xxnA:
undetectable		 5l6eA-4xxnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		4 / 7 GLN A  48
LEU A  51
ASP A  54
LEU A  60
 None
 1.11A 5nwvA-4xxnA:
undetectable		 5nwvA-4xxnA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 126
THR A 124
ASN A 265
 None
 0.67A 5odiG-4xxnA:
undetectable		 5odiG-4xxnA:
18.62