SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 TRP A 165
ALA A 196
VAL A 193
 None
 0.75A 1c4dC-4xxpA:
undetectable
1c4dD-4xxpA:
undetectable		 1c4dC-4xxpA:
7.64
1c4dD-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.90A 1grmA-4xxpA:
undetectable		 1grmA-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.90A 1grmB-4xxpA:
undetectable		 1grmB-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		4 / 6 PRO A 244
ASP A  51
ASP A  62
TRP A  66
 None
 1.39A 1hpkA-4xxpA:
undetectable		 1hpkA-4xxpA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.93A 1jnoA-4xxpA:
undetectable		 1jnoA-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.93A 1jnoB-4xxpA:
undetectable		 1jnoB-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.87A 1jo3A-4xxpA:
undetectable		 1jo3A-4xxpA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.87A 1jo3B-4xxpA:
undetectable		 1jo3B-4xxpA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.92A 1jo4A-4xxpA:
undetectable		 1jo4A-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.92A 1jo4B-4xxpA:
undetectable		 1jo4B-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.94A 1magA-4xxpA:
undetectable		 1magA-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.94A 1magB-4xxpA:
undetectable		 1magB-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.88A 1ng8A-4xxpA:
undetectable		 1ng8A-4xxpA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.88A 1ng8B-4xxpA:
undetectable		 1ng8B-4xxpA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.94A 1nruA-4xxpA:
undetectable		 1nruA-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 174
VAL A 162
TRP A 200
 None
 0.94A 1nruB-4xxpA:
undetectable		 1nruB-4xxpA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		5 / 9 LEU A 152
VAL A 177
GLY A 208
VAL A 162
ILE A 160
 None
 1.01A 1ohrB-4xxpA:
undetectable		 1ohrB-4xxpA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		4 / 8 TRP A 147
GLU A 164
VAL A 193
TRP A 165
 None
 1.12A 1rs6A-4xxpA:
undetectable
1rs6B-4xxpA:
undetectable		 1rs6A-4xxpA:
17.55
1rs6B-4xxpA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ALA A 196
VAL A 193
TRP A 165
 None
 0.89A 1tkqB-4xxpA:
undetectable		 1tkqB-4xxpA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		4 / 8 TRP A 147
GLU A 164
VAL A 193
TRP A 165
 None
 1.05A 3b3pA-4xxpA:
undetectable
3b3pB-4xxpA:
undetectable		 3b3pA-4xxpA:
17.55
3b3pB-4xxpA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 GLU A 159
TRP A 151
LYS A 185
 None
 1.26A 4k7aA-4xxpA:
undetectable		 4k7aA-4xxpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		5 / 11 LEU A 152
VAL A 177
GLY A 208
VAL A 162
ILE A 160
 None
 0.91A 4qgiB-4xxpA:
undetectable		 4qgiB-4xxpA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		4 / 8 TRP A 147
GLU A 164
VAL A 193
TRP A 165
 None
 1.16A 4uchA-4xxpA:
undetectable
4uchB-4xxpA:
undetectable		 4uchA-4xxpA:
17.74
4uchB-4xxpA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 ARG A 136
ASP A 270
TRP A 271
 None
MG  A 301 (-3.1A)
None
 0.22A 4xdqA-4xxpA:
34.0		 4xdqA-4xxpA:
58.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		5 / 12 GLY A 167
TYR A 166
SER A 253
ALA A 146
TYR A 263
 None
 1.08A 4ymgB-4xxpA:
undetectable		 4ymgB-4xxpA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		5 / 11 ALA A 265
ALA A 109
VAL A 250
LEU A 248
LEU A 139
 None
 1.16A 5eb5A-4xxpA:
undetectable		 5eb5A-4xxpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		4 / 6 ASP A  62
ASP A 270
ARG A 273
GLN A  50
 None
MG  A 301 (-3.1A)
None
None
 1.28A 5l6eA-4xxpA:
undetectable		 5l6eA-4xxpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 HIS A 189
ASN A 190
ALA A 192
 None
 0.78A 5n4tB-4xxpA:
undetectable		 5n4tB-4xxpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)
(Mycobacterium
avium) 		3 / 3 GLU A 164
TRP A 171
HIS A 178
 None
 1.00A 5xipA-4xxpA:
undetectable		 5xipA-4xxpA:
17.80