SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BL9_A_CP6A1240_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	5 / 12	ILE A 163 LEU A 167 PHE A 233 ILE A 200 ILE A 278	None	1.08A	2bl9A-4xxtA: undetectable	2bl9A-4xxtA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JJP_A_KLNA413_1 (CYTOCHROME P450 113A1)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	5 / 12	ALA A 146 LEU A 149 ALA A 150 THR A 155 ILE A 280	EDO A 301 ( 4.7A) EDO A 301 ( 4.2A) None None None	0.95A	2jjpA-4xxtA: undetectable	2jjpA-4xxtA: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNV_D_QI9D602_0 (CYTOCHROME P450 2D6)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	4 / 7	PHE A 86 SER A 89 VAL A 109 PHE A 97	None	0.95A	4wnvD-4xxtA: undetectable	4wnvD-4xxtA: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	4 / 5	ASP A 270 ALA A 265 THR A 225 TYR A 269	None	1.31A	4z4gA-4xxtA: undetectable	4z4gA-4xxtA: 14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4H_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	4 / 5	ASP A 270 ALA A 265 THR A 225 TYR A 269	None	1.29A	4z4hA-4xxtA: undetectable	4z4hA-4xxtA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4I_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	4 / 6	ASP A 270 ALA A 265 THR A 225 TYR A 269	None	1.28A	4z4iA-4xxtA: undetectable	4z4iA-4xxtA: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z69_I_DIFI1006_1 (SERUM ALBUMIN)	4xxt	FUSION OF PREDICTED ZN-DEPENDENT AMIDASE/PEPTIDASE (CELL WALL HYDROLASE/DD-CARBOXY PEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDIN G DOMAIN (Clostridium acetobutylicum)	5 / 10	ARG A 95 PHE A 86 LEU A 117 ILE A 69 SER A 110	None	1.47A	4z69I-4xxtA: undetectable	4z69I-4xxtA: 17.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2BL9_A_CP6A1240_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",5,"ILE A 163;LEU A 167;PHE A 233;ILE A 200;ILE A 278","None","1.08A","2bl9A-4xxtA:undetectable","2bl9A-4xxtA:20.82"],["2JJP_A_KLNA413_1","CYTOCHROME P450 113A1","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",5,"ALA A 146;LEU A 149;ALA A 150;THR A 155;ILE A 280","EDO A 301 ( 4.7A);EDO A 301 ( 4.2A);None;None;None","0.95A","2jjpA-4xxtA:undetectable","2jjpA-4xxtA:19.62"],["4WNV_D_QI9D602_0","CYTOCHROME P450 2D6","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",4,"PHE A  86;SER A  89;VAL A 109;PHE A  97","None","0.95A","4wnvD-4xxtA:undetectable","4wnvD-4xxtA:17.32"],["4Z4G_A_IPHA905_0","PROTEIN ARGONAUTE-2","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",4,"ASP A 270;ALA A 265;THR A 225;TYR A 269","None","1.31A","4z4gA-4xxtA:undetectable","4z4gA-4xxtA:14.49"],["4Z4H_A_IPHA905_0","PROTEIN ARGONAUTE-2","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",4,"ASP A 270;ALA A 265;THR A 225;TYR A 269","None","1.29A","4z4hA-4xxtA:undetectable","4z4hA-4xxtA:14.60"],["4Z4I_A_IPHA904_0","PROTEIN ARGONAUTE-2","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",4,"ASP A 270;ALA A 265;THR A 225;TYR A 269","None","1.28A","4z4iA-4xxtA:undetectable","4z4iA-4xxtA:14.60"],["4Z69_I_DIFI1006_1","SERUM ALBUMIN","4xxt","FUSION OF PREDICTED ZN-DEPENDENT AMIDASE\/PEPTIDASE (CELL WALL HYDROLASE\/DD-CARBOXYPEPTIDASE FAMILY) AND UNCHARACTERIZED DOMAIN OF ERFK FAMILY PEPTODOGLYCAN-BINDING DOMAIN","Clostridium acetobutylicum",5,"ARG A  95;PHE A  86;LEU A 117;ILE A  69;SER A 110","None","1.47A","4z69I-4xxtA:undetectable","4z69I-4xxtA:17.83"]]